Substance P enhances IL-2 expression in activated human T cells

Jurkat and HUT 78 T cell lines, as well as peripheral blood human T cells activated with PHA plus PMA were used to investigate the capacity of substance P (SP) neuropeptide to regulate IL-2 production. By using Northern blot analysis and dosage of the IL-2 release in cell supernatants, we show that...

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Veröffentlicht in:	The Journal of immunology (1950) 1992-06, Vol.148 (11), p.3498-3504
Hauptverfasser:	Calvo, CF, Chavanel, G, Senik, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression - drug effects Humans Immunobiology In Vitro Techniques Interleukin-2 - metabolism Lymphocyte Activation Lymphokines, interleukins ( function, expression) Regulatory factors and their cellular receptors RNA, Messenger - genetics Substance P - analogs & derivatives Substance P - pharmacology T-Lymphocytes - physiology Tetradecanoylphorbol Acetate - pharmacology Time Factors Tumor Cells, Cultured
Online-Zugang:	Volltext
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