Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus)
Esterase-27A (ES-27A) was characterized in strain A/WySnA by a cascade of seven bands seen after disc electrophoresis of serum and subsequent staining for esterase. ES-27A catalyses the hydrolysis of thiocholine butyrate and is strongly inhibited by 100 μm tetraisopropyl pyrophosphamide (isoOMPA). H...
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| Veröffentlicht in: | Genetical Research 1991-02, Vol.57 (1), p.61-70 |
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| creator | von Deimling, O. H. Gaa, A. |
| description | Esterase-27A (ES-27A) was characterized in strain A/WySnA by a cascade of seven bands seen after disc electrophoresis of serum and subsequent staining for esterase. ES-27A catalyses the hydrolysis of thiocholine butyrate and is strongly inhibited by 100 μm tetraisopropyl pyrophosphamide (isoOMPA). Hence, the enzyme was concluded to be a cholinesterase EC 3.1.1.8. A heat-labile form termed ES-27B was represented by strain AKR/Han. From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere–Car-2–Es-26–Es-27–Amy-1–Adh-1. |
| doi_str_mv | 10.1017/S0016672300029050 |
| format | Article |
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From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere–Car-2–Es-26–Es-27–Amy-1–Adh-1.</description><identifier>ISSN: 0016-6723</identifier><identifier>EISSN: 1469-5073</identifier><identifier>DOI: 10.1017/S0016672300029050</identifier><identifier>PMID: 2040456</identifier><identifier>CODEN: GENRA8</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Animals ; Biological and medical sciences ; Cholinesterases - blood ; Cholinesterases - genetics ; Cholinesterases - metabolism ; Chromosome Mapping ; Classical genetics, quantitative genetics, hybrids ; Female ; Fundamental and applied biological sciences. Psychology ; Genetics of eukaryotes. 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H.</creatorcontrib><creatorcontrib>Gaa, A.</creatorcontrib><title>Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus)</title><title>Genetical Research</title><addtitle>Genet. Res</addtitle><description>Esterase-27A (ES-27A) was characterized in strain A/WySnA by a cascade of seven bands seen after disc electrophoresis of serum and subsequent staining for esterase. ES-27A catalyses the hydrolysis of thiocholine butyrate and is strongly inhibited by 100 μm tetraisopropyl pyrophosphamide (isoOMPA). Hence, the enzyme was concluded to be a cholinesterase EC 3.1.1.8. A heat-labile form termed ES-27B was represented by strain AKR/Han. From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere–Car-2–Es-26–Es-27–Amy-1–Adh-1.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cholinesterases - blood</subject><subject>Cholinesterases - genetics</subject><subject>Cholinesterases - metabolism</subject><subject>Chromosome Mapping</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Vertebrata</subject><issn>0016-6723</issn><issn>1469-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EKkvhB3BA8gXUSgTGcWInR1pKi1RAaOFsTWyn6yWJt3YiQY_95ThsWg5IXGyN3vdGz8-EPGfwhgGTb9cATAiZcwDIayjhAVmxQtRZCZI_JKtZzmb9MXkS4zaNHCp5QA5yKKAoxYrcnjivN7Z3GjuKg6FXdrCj01RvMKAebXA3ODo_UN9SG9OM0Wa5pEdn63Qdv6bjxtIetz7QXYexx-T0nRvu2Nk3Ixs_paH_cx59miLtp6inborHT8mjFrtony33Ifn-4ezb6UV2-eX84-m7y0wXJRszRGbyRkJlMTeGoQQhGJQiryvQtTasaUxRNbaCPL3SClsIaUSJWoMxXLf8kLza790Ffz2lfKp3Uduuw8GmWIqJnLOqKhLI9qAOPsZgW7ULrsfwSzFQc-_qn96T58WyfGp6a-4dS9FJf7noGFPVbcBBu_h3cS3StwFPXLbnXOrv572O4YcSkstSifOvip2sGRT8vfqceL5kxb4JzlxZtfVTGFKR_0n7G6fBqFg</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>von Deimling, O. 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H. ; Gaa, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-aa1d2b708ea2dd1a706610562980c9cd1bbd48be802130e6e467d65acc0dd3cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cholinesterases - blood</topic><topic>Cholinesterases - genetics</topic><topic>Cholinesterases - metabolism</topic><topic>Chromosome Mapping</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Vertebrata</topic><toplevel>online_resources</toplevel><creatorcontrib>von Deimling, O. H.</creatorcontrib><creatorcontrib>Gaa, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Genetical Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>von Deimling, O. H.</au><au>Gaa, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus)</atitle><jtitle>Genetical Research</jtitle><addtitle>Genet. Res</addtitle><date>1991-02-01</date><risdate>1991</risdate><volume>57</volume><issue>1</issue><spage>61</spage><epage>70</epage><pages>61-70</pages><issn>0016-6723</issn><eissn>1469-5073</eissn><coden>GENRA8</coden><abstract>Esterase-27A (ES-27A) was characterized in strain A/WySnA by a cascade of seven bands seen after disc electrophoresis of serum and subsequent staining for esterase. ES-27A catalyses the hydrolysis of thiocholine butyrate and is strongly inhibited by 100 μm tetraisopropyl pyrophosphamide (isoOMPA). Hence, the enzyme was concluded to be a cholinesterase EC 3.1.1.8. A heat-labile form termed ES-27B was represented by strain AKR/Han. From a three-point cross (AKR/Han, A/Wy) and a five-point cross (AKR/Han, SEG/1), the gene order on chromosome 3 was concluded to be centromere–Car-2–Es-26–Es-27–Amy-1–Adh-1.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>2040456</pmid><doi>10.1017/S0016672300029050</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Genetical Research, 1991-02, Vol.57 (1), p.61-70 |
| issn | 0016-6723 1469-5073 |
| language | eng |
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| source | Cambridge Journals Open Access |
| subjects | Animals Biological and medical sciences Cholinesterases - blood Cholinesterases - genetics Cholinesterases - metabolism Chromosome Mapping Classical genetics, quantitative genetics, hybrids Female Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Male Mice Mice, Inbred Strains Vertebrata |
| title | Biochemical and genetic characterization of esterase-27 (ES-27), the major plasma cholinesterase of the house mouse (Mus musculus) |
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