Attempt to Correlate Urine Arsenic Excretion with Clinical Course during Melarsoprol Therapy of Patients with Rhodesian Trypanosomiasis
This study enrolled 28 CNS-involved patients with Trypanosoma brucei rhodesiense at the Kenya Trypanosomiasis Research Institute (Alupe, Kenya) to examine treatment efficacy and toxicity of melarsoprol in relation to renal excretion/dose relationships. This study complied with World Health Organizat...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 1997-06, Vol.56 (6), p.632-636 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Harrison, Shannon M Harris, Richard W Bales, James D., Jr |
| description | This study enrolled 28 CNS-involved patients with Trypanosoma brucei rhodesiense at the Kenya Trypanosomiasis Research Institute (Alupe, Kenya) to examine treatment efficacy and toxicity of melarsoprol in relation to renal excretion/dose relationships. This study complied with World Health Organization treatment recommendations, initially treating with suramin followed by three courses of melarsoprol. Traced study patients had a relapse rate of 4.1%. The toxicity and crude death rate was 7.1%. Total urine arsenic output was measured between 24 and 48 hr after the last dose for each course. The range of means of total urine arsenic output between the three treatment courses was 356-511 micrograms. There was no correlation comparing melarsoprol dose, estimated creatine clearance, or urine arsenic output. Urinary pharmacokinetic parameters are not predictive of toxicity or therapeutic efficacy. |
| doi_str_mv | 10.4269/ajtmh.1997.56.632 |
| format | Article |
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This study complied with World Health Organization treatment recommendations, initially treating with suramin followed by three courses of melarsoprol. Traced study patients had a relapse rate of 4.1%. The toxicity and crude death rate was 7.1%. Total urine arsenic output was measured between 24 and 48 hr after the last dose for each course. The range of means of total urine arsenic output between the three treatment courses was 356-511 micrograms. There was no correlation comparing melarsoprol dose, estimated creatine clearance, or urine arsenic output. 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Drug treatments</subject><subject>Suramin - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Trypanocidal Agents - adverse effects</subject><subject>Trypanocidal Agents - therapeutic use</subject><subject>Trypanosoma brucei rhodesiense</subject><subject>Trypanosomiasis, African - drug therapy</subject><subject>Trypanosomiasis, African - urine</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtu1DAUhiMEKkPhAVggeQHsMvgWO16ORuUiFYHQdG2dOE7jKomD7SidJ-C18XRGXVny-f7_HH1F8Z7gLadCfYGHNPZbopTcVmIrGH1RbAiXoiSCVy-LDcaYlkow-bp4E-MDxqSmhFwVV4oyLBXfFP92KdlxTih5tPch2AGSRXfBTRbtQrSTM-jm0QSbnJ_Q6lKP9oPLvzBkfskEapdM36OfORqin4Mf0KG3AeYj8h36DcnZKcVz9k_vWxsdTOgQjjNMPvrRQXTxbfGqgyHad5f3urj7enPYfy9vf337sd_dlobVIpUgG6C4MUBlZTrgqm4Zg6bmVMmmBskk5rzlrW0JrmhHQDWV6DrT1BRMy1p2XXw-9-Y7_y42Jj26aOwwwGT9EjURlEohSQbJGTTBxxhsp-fgRghHTbA-yddP8vVJvq6EzvJz5sOlfGlG2z4nLrbz_ONlDjEL7AJMxsVnjEpOmTqt_nTGenffry5YHUcYhlxK9Lqup2VP6_4DjcCezQ</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>Harrison, Shannon M</creator><creator>Harris, Richard W</creator><creator>Bales, James D., Jr</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope></search><sort><creationdate>19970601</creationdate><title>Attempt to Correlate Urine Arsenic Excretion with Clinical Course during Melarsoprol Therapy of Patients with Rhodesian Trypanosomiasis</title><author>Harrison, Shannon M ; Harris, Richard W ; Bales, James D., Jr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-a7ba20bca275cfa498d33ab84297b8a737044d4ded1052f1a9b56ffcb82acd3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Arsenic - urine</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Creatinine - blood</topic><topic>Creatinine - urine</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melarsoprol - adverse effects</topic><topic>Melarsoprol - therapeutic use</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Suramin - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Trypanocidal Agents - adverse effects</topic><topic>Trypanocidal Agents - therapeutic use</topic><topic>Trypanosoma brucei rhodesiense</topic><topic>Trypanosomiasis, African - drug therapy</topic><topic>Trypanosomiasis, African - urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harrison, Shannon M</creatorcontrib><creatorcontrib>Harris, Richard W</creatorcontrib><creatorcontrib>Bales, James D., Jr</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harrison, Shannon M</au><au>Harris, Richard W</au><au>Bales, James D., Jr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attempt to Correlate Urine Arsenic Excretion with Clinical Course during Melarsoprol Therapy of Patients with Rhodesian Trypanosomiasis</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>56</volume><issue>6</issue><spage>632</spage><epage>636</epage><pages>632-636</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>This study enrolled 28 CNS-involved patients with Trypanosoma brucei rhodesiense at the Kenya Trypanosomiasis Research Institute (Alupe, Kenya) to examine treatment efficacy and toxicity of melarsoprol in relation to renal excretion/dose relationships. 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| ispartof | The American journal of tropical medicine and hygiene, 1997-06, Vol.56 (6), p.632-636 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Arsenic - urine Biological and medical sciences Child Child, Preschool Creatinine - blood Creatinine - urine Drug Therapy, Combination Female Humans Male Medical sciences Melarsoprol - adverse effects Melarsoprol - therapeutic use Middle Aged Pharmacology. Drug treatments Suramin - therapeutic use Treatment Outcome Trypanocidal Agents - adverse effects Trypanocidal Agents - therapeutic use Trypanosoma brucei rhodesiense Trypanosomiasis, African - drug therapy Trypanosomiasis, African - urine |
| title | Attempt to Correlate Urine Arsenic Excretion with Clinical Course during Melarsoprol Therapy of Patients with Rhodesian Trypanosomiasis |
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