Sodium Stibogluconate (Pentostam) Overdose during Treatment of American Cutaneous Leishmaniasis
A 27-year-old woman who acquired cutaneous leishmaniasis in Central America was inadvertently treated with 10 times the intended daily dose of the pentavalent antimonial compound sodium stibogluconate (Pentostam): 8500 mg (143 mg/kg) instead of 850 mg. The patient felt “wiped out” during the 4-h inf...
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| Veröffentlicht in: | The Journal of infectious diseases 1992-05, Vol.165 (5), p.968-971 |
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| container_title | The Journal of infectious diseases |
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| creator | Herwaldt, Barbara L. Kaye, Elaine T. Lepore, Timothy J. Berman, Jonathan D. Baden, Howard P. |
| description | A 27-year-old woman who acquired cutaneous leishmaniasis in Central America was inadvertently treated with 10 times the intended daily dose of the pentavalent antimonial compound sodium stibogluconate (Pentostam): 8500 mg (143 mg/kg) instead of 850 mg. The patient felt “wiped out” during the 4-h infusion of the drug. After the mistake in dosing was discovered, she was vigorously hydrated and carefully monitored in an intensive care unit for >48 h. Her vital signs were stable, and no arrhythmias were noted. Her alanine aminotransferase level rose briefly to 2.4 times the upper limit of normal, and her white blood cell count briefly fell 43% to a low of 3700/µI. Her skin lesions subsequently healed without further therapy. Although sodium stibogluconate has been associated with a variety of side effects, in this case, a single high dose of the drug was tolerated without serious toxicity. |
| doi_str_mv | 10.1093/infdis/165.5.968 |
| format | Article |
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The patient felt “wiped out” during the 4-h infusion of the drug. After the mistake in dosing was discovered, she was vigorously hydrated and carefully monitored in an intensive care unit for >48 h. Her vital signs were stable, and no arrhythmias were noted. Her alanine aminotransferase level rose briefly to 2.4 times the upper limit of normal, and her white blood cell count briefly fell 43% to a low of 3700/µI. Her skin lesions subsequently healed without further therapy. Although sodium stibogluconate has been associated with a variety of side effects, in this case, a single high dose of the drug was tolerated without serious toxicity.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/165.5.968</identifier><identifier>PMID: 1314873</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Animals ; Antimony ; Antimony Sodium Gluconate - administration & dosage ; Antimony Sodium Gluconate - poisoning ; Antimony Sodium Gluconate - therapeutic use ; Biological and medical sciences ; Concise Communications ; Cutaneous leishmaniasis ; Dosage ; Drug intoxications. Doping ; Drug Overdose - therapy ; Female ; Fluid Therapy ; Humans ; Infusions, Intravenous ; Intensive care units ; Leishmania braziliensis - isolation & purification ; Leishmaniasis ; Leishmaniasis, Cutaneous - drug therapy ; Lesions ; Medical sciences ; Overdose ; Pharmacology. Drug treatments ; Recommendations ; Sodium ; Urine</subject><ispartof>The Journal of infectious diseases, 1992-05, Vol.165 (5), p.968-971</ispartof><rights>Copyright 1992 The University of Chicago</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-ce0cffdf975b12a26bb90872bf3045f11fe6d7523328dca32ea2f97ca7c8d2ec3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30112164$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30112164$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5515174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1314873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herwaldt, Barbara L.</creatorcontrib><creatorcontrib>Kaye, Elaine T.</creatorcontrib><creatorcontrib>Lepore, Timothy J.</creatorcontrib><creatorcontrib>Berman, Jonathan D.</creatorcontrib><creatorcontrib>Baden, Howard P.</creatorcontrib><title>Sodium Stibogluconate (Pentostam) Overdose during Treatment of American Cutaneous Leishmaniasis</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>A 27-year-old woman who acquired cutaneous leishmaniasis in Central America was inadvertently treated with 10 times the intended daily dose of the pentavalent antimonial compound sodium stibogluconate (Pentostam): 8500 mg (143 mg/kg) instead of 850 mg. The patient felt “wiped out” during the 4-h infusion of the drug. After the mistake in dosing was discovered, she was vigorously hydrated and carefully monitored in an intensive care unit for >48 h. Her vital signs were stable, and no arrhythmias were noted. Her alanine aminotransferase level rose briefly to 2.4 times the upper limit of normal, and her white blood cell count briefly fell 43% to a low of 3700/µI. Her skin lesions subsequently healed without further therapy. Although sodium stibogluconate has been associated with a variety of side effects, in this case, a single high dose of the drug was tolerated without serious toxicity.</description><subject>Adult</subject><subject>Animals</subject><subject>Antimony</subject><subject>Antimony Sodium Gluconate - administration & dosage</subject><subject>Antimony Sodium Gluconate - poisoning</subject><subject>Antimony Sodium Gluconate - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Concise Communications</subject><subject>Cutaneous leishmaniasis</subject><subject>Dosage</subject><subject>Drug intoxications. Doping</subject><subject>Drug Overdose - therapy</subject><subject>Female</subject><subject>Fluid Therapy</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Intensive care units</subject><subject>Leishmania braziliensis - isolation & purification</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis, Cutaneous - drug therapy</subject><subject>Lesions</subject><subject>Medical sciences</subject><subject>Overdose</subject><subject>Pharmacology. Drug treatments</subject><subject>Recommendations</subject><subject>Sodium</subject><subject>Urine</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1v1DAURS0EKkNhzwbJC4RgkamfHdvJskTAII3USi0V6sZy_FFckrjYDoJ_TyBDu3qLc-7V00XoJZAtkJadhMnbkE9A8C3ftqJ5hDbAmayEAPYYbQihtIKmbZ-iZznfEkJqJuQROgIGdSPZBqmLaMM84osS-ngzzCZOujj89txNJeaix3f47KdLNmaH7ZzCdIMvk9NlXDiOHp-OLgWjJ9zNRU8uzhnvXcjfRj0FnUN-jp54PWT34nCP0ZePHy67XbU_-_S5O91Xpoa6VMYR4731reQ9UE1F37ekkbT3jNTcA3gnrOSUMdpYoxl1mi6y0dI0ljrDjtGbtfcuxR-zy0WNIRs3DOtTCgSlUoh6EckqmhRzTs6ruxRGnX4rIOrvpmrddElwxdWy6RJ5deie-9HZh8A64sJfH7jORg8-6cksBf81zoGDrB9qbnOJ6R4zAkDh32fVykMu7tc91-m7EpJJrnZfr1VHrq927887dcX-AAFBm0g</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Herwaldt, Barbara L.</creator><creator>Kaye, Elaine T.</creator><creator>Lepore, Timothy J.</creator><creator>Berman, Jonathan D.</creator><creator>Baden, Howard P.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19920501</creationdate><title>Sodium Stibogluconate (Pentostam) Overdose during Treatment of American Cutaneous Leishmaniasis</title><author>Herwaldt, Barbara L. ; Kaye, Elaine T. ; Lepore, Timothy J. ; Berman, Jonathan D. ; Baden, Howard P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-ce0cffdf975b12a26bb90872bf3045f11fe6d7523328dca32ea2f97ca7c8d2ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Antimony</topic><topic>Antimony Sodium Gluconate - administration & dosage</topic><topic>Antimony Sodium Gluconate - poisoning</topic><topic>Antimony Sodium Gluconate - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Concise Communications</topic><topic>Cutaneous leishmaniasis</topic><topic>Dosage</topic><topic>Drug intoxications. Doping</topic><topic>Drug Overdose - therapy</topic><topic>Female</topic><topic>Fluid Therapy</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Intensive care units</topic><topic>Leishmania braziliensis - isolation & purification</topic><topic>Leishmaniasis</topic><topic>Leishmaniasis, Cutaneous - drug therapy</topic><topic>Lesions</topic><topic>Medical sciences</topic><topic>Overdose</topic><topic>Pharmacology. Drug treatments</topic><topic>Recommendations</topic><topic>Sodium</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herwaldt, Barbara L.</creatorcontrib><creatorcontrib>Kaye, Elaine T.</creatorcontrib><creatorcontrib>Lepore, Timothy J.</creatorcontrib><creatorcontrib>Berman, Jonathan D.</creatorcontrib><creatorcontrib>Baden, Howard P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herwaldt, Barbara L.</au><au>Kaye, Elaine T.</au><au>Lepore, Timothy J.</au><au>Berman, Jonathan D.</au><au>Baden, Howard P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sodium Stibogluconate (Pentostam) Overdose during Treatment of American Cutaneous Leishmaniasis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>165</volume><issue>5</issue><spage>968</spage><epage>971</epage><pages>968-971</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>A 27-year-old woman who acquired cutaneous leishmaniasis in Central America was inadvertently treated with 10 times the intended daily dose of the pentavalent antimonial compound sodium stibogluconate (Pentostam): 8500 mg (143 mg/kg) instead of 850 mg. The patient felt “wiped out” during the 4-h infusion of the drug. After the mistake in dosing was discovered, she was vigorously hydrated and carefully monitored in an intensive care unit for >48 h. Her vital signs were stable, and no arrhythmias were noted. Her alanine aminotransferase level rose briefly to 2.4 times the upper limit of normal, and her white blood cell count briefly fell 43% to a low of 3700/µI. Her skin lesions subsequently healed without further therapy. Although sodium stibogluconate has been associated with a variety of side effects, in this case, a single high dose of the drug was tolerated without serious toxicity.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>1314873</pmid><doi>10.1093/infdis/165.5.968</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 1992-05, Vol.165 (5), p.968-971 |
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| source | Jstor Complete Legacy; MEDLINE |
| subjects | Adult Animals Antimony Antimony Sodium Gluconate - administration & dosage Antimony Sodium Gluconate - poisoning Antimony Sodium Gluconate - therapeutic use Biological and medical sciences Concise Communications Cutaneous leishmaniasis Dosage Drug intoxications. Doping Drug Overdose - therapy Female Fluid Therapy Humans Infusions, Intravenous Intensive care units Leishmania braziliensis - isolation & purification Leishmaniasis Leishmaniasis, Cutaneous - drug therapy Lesions Medical sciences Overdose Pharmacology. Drug treatments Recommendations Sodium Urine |
| title | Sodium Stibogluconate (Pentostam) Overdose during Treatment of American Cutaneous Leishmaniasis |
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