Muscle MRS detects elevated PDE/ATP ratios prior to fatty infiltration in Becker muscular dystrophy

Becker muscular dystrophy (BMD) is characterized by progressive muscle weakness. Muscles show structural changes (fatty infiltration, fibrosis) and metabolic changes, both of which can be assessed using MRI and MRS. It is unknown at what stage of the disease process metabolic changes arise and how t...

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Veröffentlicht in:	NMR in biomedicine 2014-11, Vol.27 (11), p.1371-1377
Hauptverfasser:	Wokke, B. H., Hooijmans, M. T., van den Bergen, J. C., Webb, A. G., Verschuuren, J. J., Kan, H. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analysis Adipose Tissue - pathology Adult Aged Becker muscular dystrophy Case-Control Studies Disability Evaluation Disease Progression DNA Mutational Analysis Dystrophin - genetics Female Glycerophospholipids - analysis Glycerylphosphorylcholine - analysis Humans Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Metabolism Metabolites Middle Aged MRS Muscle, Skeletal - chemistry Muscle, Skeletal - pathology Muscular dystrophy Muscular Dystrophy, Duchenne - genetics Muscular Dystrophy, Duchenne - metabolism Muscular Dystrophy, Duchenne - pathology PDE phosphor spectroscopy Phosphorus Isotopes Protons Ratios Young Adult
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