Polycomb Potentiates Meis2 Activation in Midbrain by Mediating Interaction of the Promoter with a Tissue-Specific Enhancer

Polycomb-group (PcG) proteins mediate repression of developmental regulators in a reversible manner, contributing to their spatiotemporally regulated expression. However, it is poorly understood how PcG-repressed genes are activated by developmental cues. Here, we used the mouse Meis2 gene as a mode...

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Veröffentlicht in:	Developmental cell 2014-01, Vol.28 (1), p.94-101
Hauptverfasser:	Kondo, Takashi, Isono, Kyoichi, Kondo, Kaori, Endo, Takaho A., Itohara, Shigeyoshi, Vidal, Miguel, Koseki, Haruhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Enhancer Elements, Genetic Gene Expression Regulation, Developmental Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Mesencephalon - metabolism Mice Organ Specificity Polycomb Repressive Complex 1 - chemistry Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Promoter Regions, Genetic Prosencephalon - metabolism Protein Binding Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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