Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice

Pulmonary hypertension (PH) is a disease with a poor prognosis characterized by a vascular remodeling process and an increase in pulmonary vascular resistance. While a variety of reports demonstrated that exercise training exerts beneficial effects on exercise performance and quality of life in PH p...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2014-06, Vol.306 (11), p.L986-L995
Hauptverfasser:	Weissmann, Norbert, Peters, Dorothea M, Klöpping, Christina, Krüger, Karsten, Pilat, Christian, Katta, Susmitha, Seimetz, Michael, Ghofrani, Hossein A, Schermuly, Ralph T, Witzenrath, Martin, Seeger, Werner, Grimminger, Friedrich, Mooren, Frank C
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - genetics 3',5'-Cyclic-AMP Phosphodiesterases - metabolism Animals Exercise Therapy Exercise Tolerance Gene Expression Hypertension, Pulmonary - etiology Hypertension, Pulmonary - prevention & control Hypoxia Hypoxia - complications Hypoxia - therapy Lung - blood supply Lung - metabolism Male Medical prognosis Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - physiopathology Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Oxygen Oxygen Consumption Phosphodiesterase 5 Inhibitors - pharmacology Physical Conditioning, Animal Piperazines - pharmacology Pulmonary hypertension Purines - pharmacology Rodents Signal Transduction Sildenafil Citrate Sulfones - pharmacology Ventricular Pressure
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