Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer

Circulating tumor cells from patients with small-cell lung cancer can form tumors in mice, and their derived explants recapitulate the patients' response to chemotherapy. Small-cell lung cancer (SCLC), an aggressive neuroendocrine tumor with early dissemination and dismal prognosis, accounts fo...

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Veröffentlicht in:	Nature medicine 2014-08, Vol.20 (8), p.897-903
Hauptverfasser:	Hodgkinson, Cassandra L, Morrow, Christopher J, Li, Yaoyong, Metcalf, Robert L, Rothwell, Dominic G, Trapani, Francesca, Polanski, Radoslaw, Burt, Deborah J, Simpson, Kathryn L, Morris, Karen, Pepper, Stuart D, Nonaka, Daisuke, Greystoke, Alastair, Kelly, Paul, Bola, Becky, Krebs, Matthew G, Antonello, Jenny, Ayub, Mahmood, Faulkner, Suzanne, Priest, Lynsey, Carter, Louise, Tate, Catriona, Miller, Crispin J, Blackhall, Fiona, Brady, Ged, Dive, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/212/748 692/699/67/1612/2143 Animals Biomarkers, Tumor - blood Biomedicine Blood Cancer cells Cancer Research Care and treatment Cell Transformation, Neoplastic - genetics Cells Chemotherapy Disease Models, Animal Drug resistance Drug Resistance, Neoplasm - genetics Female Genetic aspects Humans Infectious Diseases Lung cancer Lung cancer, Small cell Lung Neoplasms - drug therapy Lung Neoplasms - genetics Metabolic Diseases Mice Mice, Inbred NOD Molecular Medicine Molecular Sequence Data Neoplasm Metastasis - pathology Neoplasm Transplantation Neoplastic Cells, Circulating - metabolism Neurosciences Patient outcomes Physiological aspects Platinum Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - genetics Transplantation, Heterologous Treatment Outcome Tumorigenesis Tumors
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