Attenuated NOx responses and myocardial ischemia, a possible risk for structural vascular disease in African men: the SABPA study
Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease i...
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| Veröffentlicht in: | Journal of human hypertension 2014-07, Vol.28 (7), p.438-443 |
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| creator | Uys, A S Malan, L van Rooyen, J M Steyn, H S Reimann, M Ziemssen, T |
| description | Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of African and Caucasian men. The study included 81 African and 94 Caucasian male teachers stratified via median splits into low and high NOx ethnic groups. Ambulatory blood pressure, electrocardiogram monitoring and ultrasound carotid intima-media thickness (CIMT) images were obtained. Cardiovascular measurements and fasting blood for NOx responses were measured during rest and on challenging the cardiovascular system with the Stroop colour-word conflict test. African men displayed significantly higher resting NOx as well as higher number of 24 h silent ischemic events than their Caucasian counterparts. Low NOx African men displayed enhanced α-adrenergic and ECG ST segment depression acute mental stress responses as well as 24 h silent ischemic events associated with CIMT (adjusted
R
2
=0.47;
β
=0.25; confidence interval (CI)=0.13, 0.41). African men demonstrated a vulnerable cardiovascular profile. Novel findings revealed α-adrenergic-driven blood pressure responses and less NO bioavailability during acute stress. The association between myocardial ischemia and CIMT in this group emphasized their risk for future coronary artery disease and cerebrovascular events. |
| doi_str_mv | 10.1038/jhh.2013.128 |
| format | Article |
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R
2
=0.47;
β
=0.25; confidence interval (CI)=0.13, 0.41). African men demonstrated a vulnerable cardiovascular profile. Novel findings revealed α-adrenergic-driven blood pressure responses and less NO bioavailability during acute stress. The association between myocardial ischemia and CIMT in this group emphasized their risk for future coronary artery disease and cerebrovascular events.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/jhh.2013.128</identifier><identifier>PMID: 24401953</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/592 ; 692/699/75/593 ; Adult ; Bioavailability ; Blood circulation disorders ; Blood pressure ; Cardiovascular disease ; Cardiovascular system ; Carotid Intima-Media Thickness ; Complications and side effects ; Coronary artery ; Demographic aspects ; EKG ; Epidemiology ; Health Administration ; Heart diseases ; Humans ; Ischemia ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Minority & ethnic groups ; Myocardial ischemia ; Myocardial Ischemia - complications ; Myocardial Ischemia - metabolism ; Nitric Oxide - metabolism ; original-article ; Public Health ; Risk ; Risk factors ; Stress response ; Vascular diseases ; Vascular Diseases - etiology ; Vasodilation ; White people</subject><ispartof>Journal of human hypertension, 2014-07, Vol.28 (7), p.438-443</ispartof><rights>Macmillan Publishers Limited 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2014</rights><rights>Macmillan Publishers Limited 2014.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-1a7e503c47f5d9ba29a698d140b2a4c34b3c5aa72e0e4b40c41aa8080085fe6e3</citedby><cites>FETCH-LOGICAL-c624t-1a7e503c47f5d9ba29a698d140b2a4c34b3c5aa72e0e4b40c41aa8080085fe6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jhh.2013.128$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jhh.2013.128$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24401953$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uys, A S</creatorcontrib><creatorcontrib>Malan, L</creatorcontrib><creatorcontrib>van Rooyen, J M</creatorcontrib><creatorcontrib>Steyn, H S</creatorcontrib><creatorcontrib>Reimann, M</creatorcontrib><creatorcontrib>Ziemssen, T</creatorcontrib><title>Attenuated NOx responses and myocardial ischemia, a possible risk for structural vascular disease in African men: the SABPA study</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of African and Caucasian men. The study included 81 African and 94 Caucasian male teachers stratified via median splits into low and high NOx ethnic groups. Ambulatory blood pressure, electrocardiogram monitoring and ultrasound carotid intima-media thickness (CIMT) images were obtained. Cardiovascular measurements and fasting blood for NOx responses were measured during rest and on challenging the cardiovascular system with the Stroop colour-word conflict test. African men displayed significantly higher resting NOx as well as higher number of 24 h silent ischemic events than their Caucasian counterparts. Low NOx African men displayed enhanced α-adrenergic and ECG ST segment depression acute mental stress responses as well as 24 h silent ischemic events associated with CIMT (adjusted
R
2
=0.47;
β
=0.25; confidence interval (CI)=0.13, 0.41). African men demonstrated a vulnerable cardiovascular profile. Novel findings revealed α-adrenergic-driven blood pressure responses and less NO bioavailability during acute stress. The association between myocardial ischemia and CIMT in this group emphasized their risk for future coronary artery disease and cerebrovascular events.</description><subject>631/443/592</subject><subject>692/699/75/593</subject><subject>Adult</subject><subject>Bioavailability</subject><subject>Blood circulation disorders</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular system</subject><subject>Carotid Intima-Media Thickness</subject><subject>Complications and side effects</subject><subject>Coronary artery</subject><subject>Demographic aspects</subject><subject>EKG</subject><subject>Epidemiology</subject><subject>Health Administration</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Minority & ethnic groups</subject><subject>Myocardial ischemia</subject><subject>Myocardial Ischemia - complications</subject><subject>Myocardial Ischemia - metabolism</subject><subject>Nitric Oxide - metabolism</subject><subject>original-article</subject><subject>Public Health</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Stress response</subject><subject>Vascular diseases</subject><subject>Vascular Diseases - etiology</subject><subject>Vasodilation</subject><subject>White people</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFks1v1DAQxSMEokvhxhlZQkIcmsV2bCfhFiq-pIoiAWdr4kwaL4mztR3EHvnP8WoLtKgC-WDJ85s3fpqXZY8ZXTNaVC82w7DmlBVrxqs72YqJUuVS8vJutqK1pHnNBT3KHoSwoXRfrO5nR1wIympZrLIfTYzoFojYkQ_n34nHsJ1dwEDAdWTazQZ8Z2EkNpgBJwsnBMh2DsG2IxJvw1fSz56E6BcTF5_AbxDMMoInnQ0IAYl1pOm9NeDIhO4liQOST82rj03qWrrdw-xeD2PAR1f3cfblzevPp-_ys_O370-bs9woLmLOoERJCyPKXnZ1C7wGVVcdE7TlIEwh2sJIgJIjRdEKagQDqGhFaSV7VFgcZ88Puls_Xy4Yop6SJxxHcDgvQTPFuWKMi-r_qFRSUsbLIqFP_0I38-JdMqK5ElSWRaX-SSUtwdM3FftDXcCI2rp-jh7MfrRukoysJRN7an0LlU6X1mNmh71N7zcanl1rGBDGOIR5XKJNi74JnhxA49OCPfZ66-0EfqcZ1fus6ZQ1vc-aTllL-JMrU0s7Yfcb_hWuBOQHIKSSu0B_zfVtgj8BcOraSA</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Uys, A S</creator><creator>Malan, L</creator><creator>van Rooyen, J M</creator><creator>Steyn, H S</creator><creator>Reimann, M</creator><creator>Ziemssen, T</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20140701</creationdate><title>Attenuated NOx responses and myocardial ischemia, a possible risk for structural vascular disease in African men: the SABPA study</title><author>Uys, A S ; Malan, L ; van Rooyen, J M ; Steyn, H S ; Reimann, M ; Ziemssen, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-1a7e503c47f5d9ba29a698d140b2a4c34b3c5aa72e0e4b40c41aa8080085fe6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/443/592</topic><topic>692/699/75/593</topic><topic>Adult</topic><topic>Bioavailability</topic><topic>Blood circulation disorders</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular system</topic><topic>Carotid Intima-Media Thickness</topic><topic>Complications and side effects</topic><topic>Coronary artery</topic><topic>Demographic aspects</topic><topic>EKG</topic><topic>Epidemiology</topic><topic>Health Administration</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Minority & ethnic groups</topic><topic>Myocardial ischemia</topic><topic>Myocardial Ischemia - 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Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uys, A S</au><au>Malan, L</au><au>van Rooyen, J M</au><au>Steyn, H S</au><au>Reimann, M</au><au>Ziemssen, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuated NOx responses and myocardial ischemia, a possible risk for structural vascular disease in African men: the SABPA study</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>28</volume><issue>7</issue><spage>438</spage><epage>443</epage><pages>438-443</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite (NOx) responses, cardiovascular function and structural vascular disease in a cohort of African and Caucasian men. The study included 81 African and 94 Caucasian male teachers stratified via median splits into low and high NOx ethnic groups. Ambulatory blood pressure, electrocardiogram monitoring and ultrasound carotid intima-media thickness (CIMT) images were obtained. Cardiovascular measurements and fasting blood for NOx responses were measured during rest and on challenging the cardiovascular system with the Stroop colour-word conflict test. African men displayed significantly higher resting NOx as well as higher number of 24 h silent ischemic events than their Caucasian counterparts. Low NOx African men displayed enhanced α-adrenergic and ECG ST segment depression acute mental stress responses as well as 24 h silent ischemic events associated with CIMT (adjusted
R
2
=0.47;
β
=0.25; confidence interval (CI)=0.13, 0.41). African men demonstrated a vulnerable cardiovascular profile. Novel findings revealed α-adrenergic-driven blood pressure responses and less NO bioavailability during acute stress. The association between myocardial ischemia and CIMT in this group emphasized their risk for future coronary artery disease and cerebrovascular events.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24401953</pmid><doi>10.1038/jhh.2013.128</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/443/592 692/699/75/593 Adult Bioavailability Blood circulation disorders Blood pressure Cardiovascular disease Cardiovascular system Carotid Intima-Media Thickness Complications and side effects Coronary artery Demographic aspects EKG Epidemiology Health Administration Heart diseases Humans Ischemia Male Medicine Medicine & Public Health Middle Aged Minority & ethnic groups Myocardial ischemia Myocardial Ischemia - complications Myocardial Ischemia - metabolism Nitric Oxide - metabolism original-article Public Health Risk Risk factors Stress response Vascular diseases Vascular Diseases - etiology Vasodilation White people |
| title | Attenuated NOx responses and myocardial ischemia, a possible risk for structural vascular disease in African men: the SABPA study |
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