Pharmacogenetics of pemetrexed combination therapy in lung cancer: pathway analysis reveals novel toxicity associations

Identification of polymorphisms that influence pemetrexed tolerability could lead to individualised treatment regimens and improve quality of life. Twenty-eight polymorphisms within eleven candidate genes were genotyped using the Illumina Human Exome v1.1 BeadChip and tested for their association wi...

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Veröffentlicht in:	The pharmacogenomics journal 2014-10, Vol.14 (5), p.411-417
Hauptverfasser:	Corrigan, A, Walker, J L, Wickramasinghe, S, Hernandez, M A, Newhouse, S J, Folarin, A A, Lewis, C M, Sanderson, J D, Spicer, J, Marinaki, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436/434 631/154/570 692/699/67/1059/99 692/699/67/1612/1350 Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomedical and Life Sciences Biomedicine Carboplatin - adverse effects Carboplatin - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Chemotherapy Cisplatin - adverse effects Cisplatin - therapeutic use Complications and side effects Dihydrofolate reductase Disease Progression Drug metabolism Drug therapy Gene Expression Genetic aspects Genetic polymorphisms Glutamates - adverse effects Glutamates - pharmacology Glutamates - therapeutic use Guanine - adverse effects Guanine - analogs & derivatives Guanine - pharmacology Guanine - therapeutic use Human Genetics Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Mesothelioma Mesothelioma - drug therapy Mesothelioma - genetics Non-small cell lung carcinoma Oncology original-article Pemetrexed Pharmacogenetics Pharmacotherapy Polymorphism, Single Nucleotide - genetics Properties Psychopharmacology Quality of life Retrospective Studies Small cell lung carcinoma Survival Rate Toxicity
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