Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis

Background The stratum corneum and tight junctions (TJs) form physical barriers in the epidermis. Dendrites of activated Langerhans cells (LCs) extend beyond the TJs to capture external antigens in mice. LCs and inflammatory dendritic epidermal cells (IDECs) are observed in the skin of patients with...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2014-10, Vol.134 (4), p.856-864
Hauptverfasser:	Yoshida, Kazue, MD, PhD, Kubo, Akiharu, MD, PhD, Fujita, Harumi, PhD, Yokouchi, Mariko, MD, Ishii, Ken, MD, PhD, Kawasaki, Hiroshi, MD, PhD, Nomura, Toshifumi, MD, PhD, Shimizu, Hiroshi, MD, PhD, Kouyama, Keisuke, MD, PhD, Ebihara, Tamotsu, MD, PhD, Nagao, Keisuke, MD, PhD, Amagai, Masayuki, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergic diseases Allergies Allergy and Immunology Animals Antigen Presentation Antigens Antigens, CD - genetics Antigens, CD - metabolism Asthma atopic dermatitis Behavior Biological and medical sciences Biopsy Cell Movement Cells, Cultured Dendritic Cells - immunology Dermatitis, Atopic - complications Dermatitis, Atopic - immunology Epidermis - pathology FcεRI Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Ichthyosis Vulgaris - complications Ichthyosis Vulgaris - immunology Immunopathology inflammatory dendritic epidermal cell Langerhans cell Langerhans Cells - immunology langerin Lectins, C-Type - genetics Lectins, C-Type - metabolism Mannose-Binding Lectins - genetics Mannose-Binding Lectins - metabolism Medical sciences Methods Mice Microscopy, Electron, Scanning Mutation Organ Culture Techniques Psoriasis - complications Psoriasis - immunology Receptors, IgE - genetics Receptors, IgE - metabolism Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin Skin allergic diseases. Stinging insect allergies stratum corneum tight junction Tight Junctions - metabolism Tight Junctions - pathology Tight Junctions - ultrastructure Transcriptome Wound healing
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