Lipopolysaccharide preconditioning facilitates M2 activation of resident microglia after spinal cord injury

The inflammatory response following spinal cord injury (SCI) has both harmful and beneficial effects; however, it can be modulated for therapeutic benefit. Endotoxin/lipopolysaccharide (LPS) preconditioning, a well‐established method for modifying the immune reaction, has been shown to attenuate dam...

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Veröffentlicht in:	Journal of neuroscience research 2014-12, Vol.92 (12), p.1647-1658
Hauptverfasser:	Hayakawa, Kentaro, Okazaki, Rentaro, Morioka, Kazuhito, Nakamura, Kozo, Tanaka, Sakae, Ogata, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Cells - drug effects Calcium-Binding Proteins - metabolism Cells, Cultured Cytokines - genetics Cytokines - metabolism Disease Models, Animal Drug Administration Schedule endotoxin Enzyme-Linked Immunosorbent Assay Female Flow Cytometry inflammation Interferon Regulatory Factor-3 - metabolism Interleukin-10 - therapeutic use Lipopolysaccharides - administration & dosage Macrophages - drug effects Mice Mice, Inbred C57BL Microfilament Proteins - metabolism Microglia - drug effects microglial activation Movement Disorders - etiology Nerve Tissue Proteins - metabolism Spinal Cord Injuries - complications Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology
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