An implantable microfluidic device for self-monitoring of intraocular pressure
Continuous 24-hour intraocular pressure self-monitoring device for glaucoma management using an implantable sensor with smartphone readout. Glaucoma is the second most common cause of blindness in the world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP...
Gespeichert in:
| Veröffentlicht in: | Nature medicine 2014-09, Vol.20 (9), p.1074-1078 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1078 |
|---|---|
| container_issue | 9 |
| container_start_page | 1074 |
| container_title | Nature medicine |
| container_volume | 20 |
| creator | Araci, Ismail E Su, Baolong Quake, Stephen R Mandel, Yossi |
| description | Continuous 24-hour intraocular pressure self-monitoring device for glaucoma management using an implantable sensor with smartphone readout.
Glaucoma is the second most common cause of blindness in the world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is a primary contributing factor. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation and is dependent on body posture, so the occasional measurements done by the eye care expert in the clinic can be misleading. Here we show that microfluidic principles can be used to develop an implantable sensor that has a limit of detection of 1 mm Hg, high sensitivity and excellent reproducibility. This device has a simple optical interface that enables IOP to be read with a smartphone camera. This sensor, with its ease of fabrication and simple design, as well as its allowance for IOP home monitoring, offers a promising approach for better care of patients with glaucoma. |
| doi_str_mv | 10.1038/nm.3621 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1622609159</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A382807277</galeid><sourcerecordid>A382807277</sourcerecordid><originalsourceid>FETCH-LOGICAL-c649t-61ae9549085410d5e79ae15c144ef08941fe0e2a656f1991b77b4da1061737b83</originalsourceid><addsrcrecordid>eNqN0ltrFDEUB_BBFFur-A1kQPDyMGvOTC6Tx6V4KRQL3vAtZGdOtimZZJrMiH57M7TabllQ8pAQfjlwTv5F8RTICkjTvvHDquE13CsOgVFegSDf7-czEW3VSsYPikcpXRBCGsLkw-KgZsAIleKw-Lj2pR1Gp_2kNw7LwXYxGDfb3nZljz9sh6UJsUzoTDUEb6cQrd-WwZTWT1GHbnY6lmPElOaIj4sHRruET673o-Lru7dfjj9Up2fvT47Xp1XHqZwqDholo5K0jALpGQqpEVgHlKIhraRgkGCtOeMGpISNEBvaayAcRCM2bXNUvLqqO8ZwOWOa1GBThy73gWFOCnhdcyKByX9TxgEaAAaZPr9DL8IcfW5kUYRn0tIbtdUOlfUm5Dl0S1G1btq6JaIWIqtqj9qix6hd8Ghsvt7xqz0-rx7zn-x98HrnQTYT_py2ek5JnXz-9P_27NuufXHLnqN203kKbp5s8GkXvryCOTEpRTRqjHbQ8ZcCopZUKj-oJZVZPrue67wZsP_r_sTw5o_SuKQL463B36n1G2js44A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1560651384</pqid></control><display><type>article</type><title>An implantable microfluidic device for self-monitoring of intraocular pressure</title><source>MEDLINE</source><source>Nature</source><source>SpringerNature Journals</source><creator>Araci, Ismail E ; Su, Baolong ; Quake, Stephen R ; Mandel, Yossi</creator><creatorcontrib>Araci, Ismail E ; Su, Baolong ; Quake, Stephen R ; Mandel, Yossi</creatorcontrib><description>Continuous 24-hour intraocular pressure self-monitoring device for glaucoma management using an implantable sensor with smartphone readout.
Glaucoma is the second most common cause of blindness in the world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is a primary contributing factor. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation and is dependent on body posture, so the occasional measurements done by the eye care expert in the clinic can be misleading. Here we show that microfluidic principles can be used to develop an implantable sensor that has a limit of detection of 1 mm Hg, high sensitivity and excellent reproducibility. This device has a simple optical interface that enables IOP to be read with a smartphone camera. This sensor, with its ease of fabrication and simple design, as well as its allowance for IOP home monitoring, offers a promising approach for better care of patients with glaucoma.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm.3621</identifier><identifier>PMID: 25150497</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>38/62 ; 631/443 ; 692/1807/1482 ; 692/308/2778 ; Biomedicine ; Blood pressure ; Cameras ; Cancer Research ; Eye ; Fabrication ; Glaucoma ; Glaucoma - physiopathology ; Humans ; Infectious Diseases ; Intraocular Pressure ; Measurement ; Metabolic Diseases ; Microfluidics - instrumentation ; Molecular Medicine ; Neurosciences ; Optical properties ; Patient monitoring ; Posture ; Prostheses and Implants ; Risk factors ; Self Care ; technical-report ; Transplants & implants</subject><ispartof>Nature medicine, 2014-09, Vol.20 (9), p.1074-1078</ispartof><rights>Springer Nature America, Inc. 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c649t-61ae9549085410d5e79ae15c144ef08941fe0e2a656f1991b77b4da1061737b83</citedby><cites>FETCH-LOGICAL-c649t-61ae9549085410d5e79ae15c144ef08941fe0e2a656f1991b77b4da1061737b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm.3621$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm.3621$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25150497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Araci, Ismail E</creatorcontrib><creatorcontrib>Su, Baolong</creatorcontrib><creatorcontrib>Quake, Stephen R</creatorcontrib><creatorcontrib>Mandel, Yossi</creatorcontrib><title>An implantable microfluidic device for self-monitoring of intraocular pressure</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>Continuous 24-hour intraocular pressure self-monitoring device for glaucoma management using an implantable sensor with smartphone readout.
Glaucoma is the second most common cause of blindness in the world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is a primary contributing factor. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation and is dependent on body posture, so the occasional measurements done by the eye care expert in the clinic can be misleading. Here we show that microfluidic principles can be used to develop an implantable sensor that has a limit of detection of 1 mm Hg, high sensitivity and excellent reproducibility. This device has a simple optical interface that enables IOP to be read with a smartphone camera. This sensor, with its ease of fabrication and simple design, as well as its allowance for IOP home monitoring, offers a promising approach for better care of patients with glaucoma.</description><subject>38/62</subject><subject>631/443</subject><subject>692/1807/1482</subject><subject>692/308/2778</subject><subject>Biomedicine</subject><subject>Blood pressure</subject><subject>Cameras</subject><subject>Cancer Research</subject><subject>Eye</subject><subject>Fabrication</subject><subject>Glaucoma</subject><subject>Glaucoma - physiopathology</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Intraocular Pressure</subject><subject>Measurement</subject><subject>Metabolic Diseases</subject><subject>Microfluidics - instrumentation</subject><subject>Molecular Medicine</subject><subject>Neurosciences</subject><subject>Optical properties</subject><subject>Patient monitoring</subject><subject>Posture</subject><subject>Prostheses and Implants</subject><subject>Risk factors</subject><subject>Self Care</subject><subject>technical-report</subject><subject>Transplants & implants</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0ltrFDEUB_BBFFur-A1kQPDyMGvOTC6Tx6V4KRQL3vAtZGdOtimZZJrMiH57M7TabllQ8pAQfjlwTv5F8RTICkjTvvHDquE13CsOgVFegSDf7-czEW3VSsYPikcpXRBCGsLkw-KgZsAIleKw-Lj2pR1Gp_2kNw7LwXYxGDfb3nZljz9sh6UJsUzoTDUEb6cQrd-WwZTWT1GHbnY6lmPElOaIj4sHRruET673o-Lru7dfjj9Up2fvT47Xp1XHqZwqDholo5K0jALpGQqpEVgHlKIhraRgkGCtOeMGpISNEBvaayAcRCM2bXNUvLqqO8ZwOWOa1GBThy73gWFOCnhdcyKByX9TxgEaAAaZPr9DL8IcfW5kUYRn0tIbtdUOlfUm5Dl0S1G1btq6JaIWIqtqj9qix6hd8Ghsvt7xqz0-rx7zn-x98HrnQTYT_py2ek5JnXz-9P_27NuufXHLnqN203kKbp5s8GkXvryCOTEpRTRqjHbQ8ZcCopZUKj-oJZVZPrue67wZsP_r_sTw5o_SuKQL463B36n1G2js44A</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Araci, Ismail E</creator><creator>Su, Baolong</creator><creator>Quake, Stephen R</creator><creator>Mandel, Yossi</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20140901</creationdate><title>An implantable microfluidic device for self-monitoring of intraocular pressure</title><author>Araci, Ismail E ; Su, Baolong ; Quake, Stephen R ; Mandel, Yossi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c649t-61ae9549085410d5e79ae15c144ef08941fe0e2a656f1991b77b4da1061737b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>38/62</topic><topic>631/443</topic><topic>692/1807/1482</topic><topic>692/308/2778</topic><topic>Biomedicine</topic><topic>Blood pressure</topic><topic>Cameras</topic><topic>Cancer Research</topic><topic>Eye</topic><topic>Fabrication</topic><topic>Glaucoma</topic><topic>Glaucoma - physiopathology</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Intraocular Pressure</topic><topic>Measurement</topic><topic>Metabolic Diseases</topic><topic>Microfluidics - instrumentation</topic><topic>Molecular Medicine</topic><topic>Neurosciences</topic><topic>Optical properties</topic><topic>Patient monitoring</topic><topic>Posture</topic><topic>Prostheses and Implants</topic><topic>Risk factors</topic><topic>Self Care</topic><topic>technical-report</topic><topic>Transplants & implants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Araci, Ismail E</creatorcontrib><creatorcontrib>Su, Baolong</creatorcontrib><creatorcontrib>Quake, Stephen R</creatorcontrib><creatorcontrib>Mandel, Yossi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Araci, Ismail E</au><au>Su, Baolong</au><au>Quake, Stephen R</au><au>Mandel, Yossi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An implantable microfluidic device for self-monitoring of intraocular pressure</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>20</volume><issue>9</issue><spage>1074</spage><epage>1078</epage><pages>1074-1078</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>Continuous 24-hour intraocular pressure self-monitoring device for glaucoma management using an implantable sensor with smartphone readout.
Glaucoma is the second most common cause of blindness in the world. It is a multifactorial disease with several risk factors, of which intraocular pressure (IOP) is a primary contributing factor. IOP measurements are used for glaucoma diagnosis and patient monitoring. IOP has wide diurnal fluctuation and is dependent on body posture, so the occasional measurements done by the eye care expert in the clinic can be misleading. Here we show that microfluidic principles can be used to develop an implantable sensor that has a limit of detection of 1 mm Hg, high sensitivity and excellent reproducibility. This device has a simple optical interface that enables IOP to be read with a smartphone camera. This sensor, with its ease of fabrication and simple design, as well as its allowance for IOP home monitoring, offers a promising approach for better care of patients with glaucoma.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>25150497</pmid><doi>10.1038/nm.3621</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 2014-09, Vol.20 (9), p.1074-1078 |
| issn | 1078-8956 1546-170X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1622609159 |
| source | MEDLINE; Nature; SpringerNature Journals |
| subjects | 38/62 631/443 692/1807/1482 692/308/2778 Biomedicine Blood pressure Cameras Cancer Research Eye Fabrication Glaucoma Glaucoma - physiopathology Humans Infectious Diseases Intraocular Pressure Measurement Metabolic Diseases Microfluidics - instrumentation Molecular Medicine Neurosciences Optical properties Patient monitoring Posture Prostheses and Implants Risk factors Self Care technical-report Transplants & implants |
| title | An implantable microfluidic device for self-monitoring of intraocular pressure |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T16%3A36%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20implantable%20microfluidic%20device%20for%20self-monitoring%20of%20intraocular%20pressure&rft.jtitle=Nature%20medicine&rft.au=Araci,%20Ismail%20E&rft.date=2014-09-01&rft.volume=20&rft.issue=9&rft.spage=1074&rft.epage=1078&rft.pages=1074-1078&rft.issn=1078-8956&rft.eissn=1546-170X&rft_id=info:doi/10.1038/nm.3621&rft_dat=%3Cgale_proqu%3EA382807277%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1560651384&rft_id=info:pmid/25150497&rft_galeid=A382807277&rfr_iscdi=true |