The role of mitochondrial reactive oxygen species in cartilage matrix destruction

Upregulation of matrix metalloproteinases (MMPs) is a hallmark of osteoarthritis progression; along with the role reactive oxygen species (ROS) may play in this process. Moreover, mitochondrial DNA damage and dysfunction are also present in osteoarthritic chondrocytes. However, there are no studies...

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Veröffentlicht in:	Molecular and cellular biochemistry 2014-12, Vol.397 (1-2), p.195-201
Hauptverfasser:	Reed, Kendra N., Wilson, Glenn, Pearsall, Albert, Grishko, Valentina I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Arthritis Biochemistry Biomedical and Life Sciences Cardiology Cartilage - metabolism Cartilage - pathology Chondrocytes - metabolism Chondrocytes - pathology Collagenases - metabolism DNA damage DNA, Mitochondrial - metabolism Extracellular Matrix - metabolism Extracellular Matrix - pathology Life Sciences Medical Biochemistry Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Oncology Osteoarthritis Osteoarthritis - metabolism Osteoarthritis - pathology Oxidative Stress Proteins Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism
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