Central vasopressin V1A receptor blockade alters patterns of cellular activation and prevents glucocorticoid habituation to repeated restraint stress exposure

Our previous experiments implicated a role for the arginine vasopressin (AVP) V1A receptor subtype in mediating the normal decline (habituation) of hypothalamic–pituitary–adrenal (HPA) axis responses to repeated restraint exposure. To explore pathways mediating the endogenous effects of central AVP...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2014-12, Vol.17 (12), p.2005-2015
Hauptverfasser:	Gray, Megan, Innala, Leyla, Viau, Victor
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - metabolism Animals Antidiuretic Hormone Receptor Antagonists - pharmacology Arginine Vasopressin - metabolism Corticosterone - metabolism Glucocorticoids - metabolism Habituation, Psychophysiologic - drug effects Habituation, Psychophysiologic - physiology Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiopathology Male Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiopathology Proto-Oncogene Proteins c-fos - metabolism Rats, Sprague-Dawley Receptors, Vasopressin - metabolism Restraint, Physical Stress, Psychological - drug therapy Stress, Psychological - physiopathology
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