Effects of ammonium chloride ingestion on phosphocreatine metabolism during moderate- and heavy-intensity plantar-flexion exercise
This study examined the effects of NH 4 Cl ingestion on phosphocreatine (PCr) metabolism during 9 min of moderate- (MOD) and heavy- (HVY) intensity constant-load isotonic plantar-flexion exercise. Healthy young adult male subjects ( n = 8) completed both a control (CON) and NH 4 Cl ingestion (ACID)...
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| Veröffentlicht in: | European journal of applied physiology 2010-04, Vol.108 (6), p.1189-1200 |
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| creator | Churchward-Venne, Tyler A. Kowalchuk, John M. Marsh, Greg D. |
| description | This study examined the effects of NH
4
Cl ingestion on phosphocreatine (PCr) metabolism during 9 min of moderate- (MOD) and heavy- (HVY) intensity constant-load isotonic plantar-flexion exercise. Healthy young adult male subjects (
n
= 8) completed both a control (CON) and NH
4
Cl ingestion (ACID) trial. Phosphorus-31 magnetic resonance spectroscopy was used to monitor changes in intracellular pH (pHi), [Pi], [PCr], and [ATP]. During the Middle (3–6 min) and Late (6–9 min) stages of HVY, ACID was associated with a higher (
P
|
| doi_str_mv | 10.1007/s00421-009-1327-8 |
| format | Article |
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4
Cl ingestion on phosphocreatine (PCr) metabolism during 9 min of moderate- (MOD) and heavy- (HVY) intensity constant-load isotonic plantar-flexion exercise. Healthy young adult male subjects (
n
= 8) completed both a control (CON) and NH
4
Cl ingestion (ACID) trial. Phosphorus-31 magnetic resonance spectroscopy was used to monitor changes in intracellular pH (pHi), [Pi], [PCr], and [ATP]. During the Middle (3–6 min) and Late (6–9 min) stages of HVY, ACID was associated with a higher (
P
< 0.05) intracellular hydrogen-ion concentration ([H
+
]i) [Middle: 246 (SD 36) vs. 202 (SD 36) mmol/l]; [Late: 236 (SD 35) vs. 200 (SD 39) mmol/l]. In addition, ACID was associated with a lower (
P
< 0.05) [PCr] relative to CON during the Early (0–3 min) [18.1 (SD 5.1) vs. 20.4 (SD 5.4) mmol/l] and Middle stages [14.1 (SD 5.4) vs. 16.7 (SD 6.0) mmol/l] of HVY. The amplitude of the primary component of PCr breakdown during the transition to HVY was greater in ACID than CON [14.5 (SD 5.8 vs. 11.3 (SD 4.8) mmol/l], however, the PCr slow component (continued slow decline in [PCr]) showed no difference (
P
> 0.05). The time constant for PCr breakdown (τPCr) was greater in HVY than MOD for both conditions [58 (SD 22) vs. 28 (SD 15) s ACID; 51 (SD 20) vs. 29 (SD 14) s CON] (
P
< 0.05). In summary, ACID increased PCr breakdown during the transition from MOD to HVY, but did not increase the magnitude of the PCr slow component.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s00421-009-1327-8</identifier><identifier>PMID: 20033204</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Administration, Oral ; Ammonium Chloride - administration & dosage ; Ankle Joint - physiology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Fundamental and applied biological sciences. Psychology ; Human Physiology ; Humans ; Male ; Metabolic Clearance Rate - drug effects ; Occupational Medicine/Industrial Medicine ; Original Article ; Phosphocreatine - metabolism ; Physical Endurance - drug effects ; Physical Endurance - physiology ; Physical Exertion - physiology ; Sports Medicine ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports ; Young Adult</subject><ispartof>European journal of applied physiology, 2010-04, Vol.108 (6), p.1189-1200</ispartof><rights>Springer-Verlag 2009</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-136b10a3556af5e0f87f5d96dac352d1dfc89b1dea5148cbf1a85794c95712cf3</citedby><cites>FETCH-LOGICAL-c433t-136b10a3556af5e0f87f5d96dac352d1dfc89b1dea5148cbf1a85794c95712cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00421-009-1327-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00421-009-1327-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22571001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20033204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Churchward-Venne, Tyler A.</creatorcontrib><creatorcontrib>Kowalchuk, John M.</creatorcontrib><creatorcontrib>Marsh, Greg D.</creatorcontrib><title>Effects of ammonium chloride ingestion on phosphocreatine metabolism during moderate- and heavy-intensity plantar-flexion exercise</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><addtitle>Eur J Appl Physiol</addtitle><description>This study examined the effects of NH
4
Cl ingestion on phosphocreatine (PCr) metabolism during 9 min of moderate- (MOD) and heavy- (HVY) intensity constant-load isotonic plantar-flexion exercise. Healthy young adult male subjects (
n
= 8) completed both a control (CON) and NH
4
Cl ingestion (ACID) trial. Phosphorus-31 magnetic resonance spectroscopy was used to monitor changes in intracellular pH (pHi), [Pi], [PCr], and [ATP]. During the Middle (3–6 min) and Late (6–9 min) stages of HVY, ACID was associated with a higher (
P
< 0.05) intracellular hydrogen-ion concentration ([H
+
]i) [Middle: 246 (SD 36) vs. 202 (SD 36) mmol/l]; [Late: 236 (SD 35) vs. 200 (SD 39) mmol/l]. In addition, ACID was associated with a lower (
P
< 0.05) [PCr] relative to CON during the Early (0–3 min) [18.1 (SD 5.1) vs. 20.4 (SD 5.4) mmol/l] and Middle stages [14.1 (SD 5.4) vs. 16.7 (SD 6.0) mmol/l] of HVY. The amplitude of the primary component of PCr breakdown during the transition to HVY was greater in ACID than CON [14.5 (SD 5.8 vs. 11.3 (SD 4.8) mmol/l], however, the PCr slow component (continued slow decline in [PCr]) showed no difference (
P
> 0.05). The time constant for PCr breakdown (τPCr) was greater in HVY than MOD for both conditions [58 (SD 22) vs. 28 (SD 15) s ACID; 51 (SD 20) vs. 29 (SD 14) s CON] (
P
< 0.05). In summary, ACID increased PCr breakdown during the transition from MOD to HVY, but did not increase the magnitude of the PCr slow component.</description><subject>Administration, Oral</subject><subject>Ammonium Chloride - administration & dosage</subject><subject>Ankle Joint - physiology</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolic Clearance Rate - drug effects</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Phosphocreatine - metabolism</subject><subject>Physical Endurance - drug effects</subject><subject>Physical Endurance - physiology</subject><subject>Physical Exertion - physiology</subject><subject>Sports Medicine</subject><subject>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</subject><subject>Young Adult</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU2L1TAUhoMozof-ADcSBGE21ZOkadOlDOMHDLjRdUiTE2-GNqlJK3O3_nJzudcZEISEJPCcN-c9LyGvGLxjAP37AtBy1gAMDRO8b9QTcs5aMTRdfT19uLPhjFyUcgcAijP1nJxxACE4tOfk9433aNdCk6dmnlMM20ztbko5OKQh_sCyhhRpXcsulbptRrOGiHTG1YxpCmWmbssVpXNymM2KDTXR0R2aX_smxBVjCeueLpOJq8mNn_D-IIn3mG0o-II882Yq-PJ0XpLvH2--XX9ubr9--nL94baxrRBrddiNDIyQsjNeInjVe-mGzhkrJHfMeauGkTk0krXKjp4ZJfuhtYPsGbdeXJKro-6S08-t-tJzKBan2hamrWjWcd5BJ1lf0Tf_oHdpy7F2pzkIrhSIrkLsCNmcSsno9ZLDbPJeM9CHfPQxH13z0Yd8tKo1r0_C2zije6j4G0gF3p4AU6yZfDaxzuiR49UMAKscP3JlOYwe82OH___9DxHUqkA</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Churchward-Venne, Tyler A.</creator><creator>Kowalchuk, John M.</creator><creator>Marsh, Greg D.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7TS</scope></search><sort><creationdate>20100401</creationdate><title>Effects of ammonium chloride ingestion on phosphocreatine metabolism during moderate- and heavy-intensity plantar-flexion exercise</title><author>Churchward-Venne, Tyler A. ; Kowalchuk, John M. ; Marsh, Greg D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-136b10a3556af5e0f87f5d96dac352d1dfc89b1dea5148cbf1a85794c95712cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Administration, Oral</topic><topic>Ammonium Chloride - administration & dosage</topic><topic>Ankle Joint - physiology</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolic Clearance Rate - drug effects</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Phosphocreatine - metabolism</topic><topic>Physical Endurance - drug effects</topic><topic>Physical Endurance - physiology</topic><topic>Physical Exertion - physiology</topic><topic>Sports Medicine</topic><topic>Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Churchward-Venne, Tyler A.</creatorcontrib><creatorcontrib>Kowalchuk, John M.</creatorcontrib><creatorcontrib>Marsh, Greg D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Physical Education Index</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Churchward-Venne, Tyler A.</au><au>Kowalchuk, John M.</au><au>Marsh, Greg D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of ammonium chloride ingestion on phosphocreatine metabolism during moderate- and heavy-intensity plantar-flexion exercise</atitle><jtitle>European journal of applied physiology</jtitle><stitle>Eur J Appl Physiol</stitle><addtitle>Eur J Appl Physiol</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>108</volume><issue>6</issue><spage>1189</spage><epage>1200</epage><pages>1189-1200</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>This study examined the effects of NH
4
Cl ingestion on phosphocreatine (PCr) metabolism during 9 min of moderate- (MOD) and heavy- (HVY) intensity constant-load isotonic plantar-flexion exercise. Healthy young adult male subjects (
n
= 8) completed both a control (CON) and NH
4
Cl ingestion (ACID) trial. Phosphorus-31 magnetic resonance spectroscopy was used to monitor changes in intracellular pH (pHi), [Pi], [PCr], and [ATP]. During the Middle (3–6 min) and Late (6–9 min) stages of HVY, ACID was associated with a higher (
P
< 0.05) intracellular hydrogen-ion concentration ([H
+
]i) [Middle: 246 (SD 36) vs. 202 (SD 36) mmol/l]; [Late: 236 (SD 35) vs. 200 (SD 39) mmol/l]. In addition, ACID was associated with a lower (
P
< 0.05) [PCr] relative to CON during the Early (0–3 min) [18.1 (SD 5.1) vs. 20.4 (SD 5.4) mmol/l] and Middle stages [14.1 (SD 5.4) vs. 16.7 (SD 6.0) mmol/l] of HVY. The amplitude of the primary component of PCr breakdown during the transition to HVY was greater in ACID than CON [14.5 (SD 5.8 vs. 11.3 (SD 4.8) mmol/l], however, the PCr slow component (continued slow decline in [PCr]) showed no difference (
P
> 0.05). The time constant for PCr breakdown (τPCr) was greater in HVY than MOD for both conditions [58 (SD 22) vs. 28 (SD 15) s ACID; 51 (SD 20) vs. 29 (SD 14) s CON] (
P
< 0.05). In summary, ACID increased PCr breakdown during the transition from MOD to HVY, but did not increase the magnitude of the PCr slow component.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20033204</pmid><doi>10.1007/s00421-009-1327-8</doi><tpages>12</tpages></addata></record> |
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| subjects | Administration, Oral Ammonium Chloride - administration & dosage Ankle Joint - physiology Biological and medical sciences Biomedical and Life Sciences Biomedicine Fundamental and applied biological sciences. Psychology Human Physiology Humans Male Metabolic Clearance Rate - drug effects Occupational Medicine/Industrial Medicine Original Article Phosphocreatine - metabolism Physical Endurance - drug effects Physical Endurance - physiology Physical Exertion - physiology Sports Medicine Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports Young Adult |
| title | Effects of ammonium chloride ingestion on phosphocreatine metabolism during moderate- and heavy-intensity plantar-flexion exercise |
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