The role of gamma delta T cells in immunity to Mycobacterium bovis infection in cattle

Accumulating evidence suggests that γδ T cells play a critical role in the early response to Mycobacterium bovis and may be key in bridging innate and adaptive immunity following infection. In vitro, γδ T cells proliferate and produce robust amounts of IFNγ in response to complex, protein and non-pr...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2014-06, Vol.159 (3-4), p.133-143
Hauptverfasser:	McGill, Jodi L., Sacco, Randy E., Baldwin, Cynthia L., Telfer, Janice C., Palmer, Mitchell V., Ray Waters, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity Animals bacterial antigens Bovine calves Cattle cell wall components Gamma delta T cells Gene Expression Regulation - immunology granuloma heat shock proteins immune response immunoglobulin G Innate immune response interferon-gamma Interleukin-1 - genetics Interleukin-1 - metabolism interleukin-4 lungs lymph nodes Lymphocyte Activation - physiology mice mycobacterial diseases Mycobacterium bovis peptidoglycans severe combined immunodeficiency structural proteins T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-lymphocytes Tuberculosis, Bovine - immunology vaccination vaccines virulence WC1
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