Mechanisms involved in kinin-induced glioma cells proliferation: the role of ERK1/2 and PI3K/Akt pathways

Gliomas are the most common malignant brain tumors in adults. Bradykinin (BK) displays an important role in cancer, although the exact role of kinin receptors in the glioma biology remains unclear. This study investigated the role of kinin B 1 and B 2 receptors (B 1 R and B 2 R) on cell proliferatio...

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Veröffentlicht in:	Journal of neuro-oncology 2014-11, Vol.120 (2), p.235-244
Hauptverfasser:	Nicoletti, Natália Fontana, Erig, Thaís Cristina, Zanin, Rafael Fernandes, Pereira, Talita Carneiro Brandão, Bogo, Mauricio Reis, Campos, Maria Martha, Morrone, Fernanda Bueno
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Blotting, Western Bradykinin - analogs & derivatives Bradykinin - pharmacology Bradykinin B1 Receptor Antagonists - pharmacology Bradykinin B2 Receptor Antagonists - pharmacology Cell Proliferation Dioxoles - pharmacology Flow Cytometry Glioma - drug therapy Glioma - metabolism Glioma - pathology Humans Laboratory Investigation Medicine Medicine & Public Health Mitogen-Activated Protein Kinase 1 - genetics Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Neurology Oncology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Real-Time Polymerase Chain Reaction Receptor, Bradykinin B1 - chemistry Receptor, Bradykinin B1 - genetics Receptor, Bradykinin B1 - metabolism Receptor, Bradykinin B2 - chemistry Receptor, Bradykinin B2 - genetics Receptor, Bradykinin B2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Sulfonamides - pharmacology Tumor Cells, Cultured
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