The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats

Drugs that are able to shift effort-related decision making in intact rats towards high-effort response options are largely unknown. Here, we examined the effects of two candidate drugs, MRZ-9547 and its l-enantiomer MRZ-9546 on progressive ratio (PR) responding using two different tasks, a standard...

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Veröffentlicht in:	The international journal of neuropsychopharmacology 2014-12, Vol.17 (12), p.2045-2056
Hauptverfasser:	Sommer, S., Danysz, W., Russ, H., Valastro, B., Flik, G., Hauber, W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism Animals Benzhydryl Compounds - pharmacology Central Nervous System Stimulants - pharmacology Choice Behavior - drug effects Corpus Striatum - drug effects Corpus Striatum - metabolism Dextroamphetamine - pharmacology Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Male Methylphenidate - pharmacology Motivation - drug effects Neuropsychological Tests Rats, Sprague-Dawley Reinforcement Schedule
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