Computational enzyme design: Transitioning from catalytic proteins to enzymes

•We compare catalytic properties of computationally designed versus native enzymes.•We identify many strengths and difficulties of current enzyme design methods.•We postulate on future avenues for basic research in computational enzyme design. The widespread interest in enzymes stem from their abili...

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Veröffentlicht in:	Current opinion in structural biology 2014-08, Vol.27, p.87-94
Hauptverfasser:	Mak, Wai Shun, Siegel, Justin B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Computational Biology - methods Enzymes - chemistry Enzymes - genetics Enzymes - metabolism Protein Engineering - methods Proteins - chemistry Proteins - genetics Proteins - metabolism
Online-Zugang:	Volltext
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