Regeneration of spermatogenesis in a mouse model of azoospermia by follicle-stimulating hormone and oestradiol

Summary Busulfan is a chemotherapeutic drug that induces sterility, azoospermia and testicular atrophy. To induce degeneration of spermatogenesis, we used different amounts of busulfan. Adult male C57Bl/6 mice were treated with 15, 30 and 45 mg kg−1 of busulfan. After 5 weeks, animals had daily inje...

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Veröffentlicht in:	Andrologia 2014-12, Vol.46 (10), p.1098-1106
Hauptverfasser:	Jafarian, A., Sadeghi, M. R., Pejhan, N., Salehkhou, S., Lakpour, N., Akhondi, M. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azoospermia - chemically induced Azoospermia - drug therapy Azoospermia - metabolism Azoospermia - pathology Busulfan Cyclin B1 - genetics Cyclin B1 - metabolism Disease Models, Animal Estradiol - pharmacology Estradiol - therapeutic use Follicle Stimulating Hormone - pharmacology Follicle Stimulating Hormone - therapeutic use hFSH Male Mice oestradiol Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism spermatogenesis Spermatogenesis - drug effects Testis - drug effects Testis - metabolism Testis - pathology testosterone Testosterone - blood
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