Structure of the cyclin-dependent kinase inhibitor p19 super(Ink4d)

In cancer, the biochemical pathways that are dominated by the two tumour-suppressor proteins, p53 and Rb, are the most frequently disrupted. Cyclin D-dependent kinases phosphorylate Rb to control its activity and they are, in turn, specifically inhibited by the Ink4 family of cyclin-dependent kinase...

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Veröffentlicht in:	Nature (London) 1997-10, Vol.389 (6654), p.999-1003
Hauptverfasser:	Luh, F Y, Archer, S J, Domaille, P J, Smith, BO, Owen, D, Brotherton, D H, Raine, ARC, Xu, Xu, Brizuela, L, Brenner, S L, Laue, ED
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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