Nephrotoxicity in goats caused by dosing with a water extract from the stems of Narthecium ossifragum plants
Seven goats were given a single dose of an aqueous extract derived from 30 g (wet weight) of Narthecium ossifragum per kg liveweight. Their serum creatinine and urea concentrations increased to day 5 but then fell to normal by day 10. Serum magnesium increased to day 4 and decreased to normal by day...
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| Veröffentlicht in: | Veterinary research communications 1997-10, Vol.21 (7), p.499-506 |
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| creator | Flåøyen, A Bratberg, B Frøslie, A Grønstøl, H Langseth, W Mantle, P G von Krogh, A |
| description | Seven goats were given a single dose of an aqueous extract derived from 30 g (wet weight) of Narthecium ossifragum per kg liveweight. Their serum creatinine and urea concentrations increased to day 5 but then fell to normal by day 10. Serum magnesium increased to day 4 and decreased to normal by day 9. Their serum calcium concentration was lower than normal on days 4, 5 and 6. Histopathological examination of the kidneys of goats killed or found dead 2, 4, 6, 8, 11 or 16 days after dosing revealed tubular epithelial cell degeneration and necrosis. Regeneration of the tubular epithelium and signs of interstitial fibroplast proliferation and fibrosis could be seen in animals killed on days 8, 11, 16 and 42. No signs of liver damage were observed in 3 goats dosed with the insoluble plant material from 40 g (wet weight) Narthecium ossifragum per kg liveweight. The total dose was divided into three doses, which were given intraruminally within 7 h. The activities of aspartate aminotransferase, gamma-glutamyltransferase and glutamate dehydrogenase remained within the normal range in all 10 goats after dosing. |
| doi_str_mv | 10.1023/a:1005994421299 |
| format | Article |
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Their serum creatinine and urea concentrations increased to day 5 but then fell to normal by day 10. Serum magnesium increased to day 4 and decreased to normal by day 9. Their serum calcium concentration was lower than normal on days 4, 5 and 6. Histopathological examination of the kidneys of goats killed or found dead 2, 4, 6, 8, 11 or 16 days after dosing revealed tubular epithelial cell degeneration and necrosis. Regeneration of the tubular epithelium and signs of interstitial fibroplast proliferation and fibrosis could be seen in animals killed on days 8, 11, 16 and 42. No signs of liver damage were observed in 3 goats dosed with the insoluble plant material from 40 g (wet weight) Narthecium ossifragum per kg liveweight. The total dose was divided into three doses, which were given intraruminally within 7 h. The activities of aspartate aminotransferase, gamma-glutamyltransferase and glutamate dehydrogenase remained within the normal range in all 10 goats after dosing.</description><identifier>ISSN: 0165-7380</identifier><identifier>DOI: 10.1023/a:1005994421299</identifier><identifier>PMID: 9345717</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Animals ; Aspartate Aminotransferases - blood ; Calcium - blood ; Creatinine - blood ; Dose-Response Relationship, Drug ; Epithelium - drug effects ; Epithelium - pathology ; gamma-Glutamyltransferase - blood ; Glutamate Dehydrogenase - blood ; Goat Diseases - etiology ; Goats ; Kidney - drug effects ; Kidney - pathology ; Kidney - physiopathology ; Liver - drug effects ; Liver - pathology ; Liver - physiopathology ; Lung - drug effects ; Lung - pathology ; Lung - physiopathology ; Magnesium - blood ; Male ; Necrosis ; Plant Extracts - analysis ; Plant Extracts - toxicity ; Plant Poisoning - etiology ; Plant Poisoning - veterinary ; Plant Stems - chemistry ; Time Factors ; Urea - blood ; Water</subject><ispartof>Veterinary research communications, 1997-10, Vol.21 (7), p.499-506</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9345717$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flåøyen, A</creatorcontrib><creatorcontrib>Bratberg, B</creatorcontrib><creatorcontrib>Frøslie, A</creatorcontrib><creatorcontrib>Grønstøl, H</creatorcontrib><creatorcontrib>Langseth, W</creatorcontrib><creatorcontrib>Mantle, P G</creatorcontrib><creatorcontrib>von Krogh, A</creatorcontrib><title>Nephrotoxicity in goats caused by dosing with a water extract from the stems of Narthecium ossifragum plants</title><title>Veterinary research communications</title><addtitle>Vet Res Commun</addtitle><description>Seven goats were given a single dose of an aqueous extract derived from 30 g (wet weight) of Narthecium ossifragum per kg liveweight. Their serum creatinine and urea concentrations increased to day 5 but then fell to normal by day 10. Serum magnesium increased to day 4 and decreased to normal by day 9. Their serum calcium concentration was lower than normal on days 4, 5 and 6. Histopathological examination of the kidneys of goats killed or found dead 2, 4, 6, 8, 11 or 16 days after dosing revealed tubular epithelial cell degeneration and necrosis. Regeneration of the tubular epithelium and signs of interstitial fibroplast proliferation and fibrosis could be seen in animals killed on days 8, 11, 16 and 42. No signs of liver damage were observed in 3 goats dosed with the insoluble plant material from 40 g (wet weight) Narthecium ossifragum per kg liveweight. The total dose was divided into three doses, which were given intraruminally within 7 h. The activities of aspartate aminotransferase, gamma-glutamyltransferase and glutamate dehydrogenase remained within the normal range in all 10 goats after dosing.</description><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Calcium - blood</subject><subject>Creatinine - blood</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epithelium - drug effects</subject><subject>Epithelium - pathology</subject><subject>gamma-Glutamyltransferase - blood</subject><subject>Glutamate Dehydrogenase - blood</subject><subject>Goat Diseases - etiology</subject><subject>Goats</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidney - physiopathology</subject><subject>Liver - drug effects</subject><subject>Liver - pathology</subject><subject>Liver - physiopathology</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lung - physiopathology</subject><subject>Magnesium - blood</subject><subject>Male</subject><subject>Necrosis</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - toxicity</subject><subject>Plant Poisoning - etiology</subject><subject>Plant Poisoning - veterinary</subject><subject>Plant Stems - chemistry</subject><subject>Time Factors</subject><subject>Urea - blood</subject><subject>Water</subject><issn>0165-7380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotUDtPwzAY9AAqpTAzIXliC_iRODEbqnhJVVlgjvz43BoldbAdtf33BNHpHjqdTofQDSX3lDD-oB4pIZWUZckok_IMzQkVVVHzhlygy5S-CSGyIXyGZpKXVU3rOerWMGxjyOHgjc9H7Hd4E1RO2KgxgcX6iG1IfrfBe5-3WOG9yhAxHHJUJmMXQ4_zFnDK0CccHF6rOGnjxx6HlLyLajPRoVO7nK7QuVNdgusTLtDXy_Pn8q1Yfby-L59WxcB4nQvmqBbCctCWl1pYKcHVTAlGlAMr6qoiDdVc_dnaKCN53Rg-PaAtEGCaL9Ddf-8Qw88IKbe9Twa6aQSEMbVUMMZkI6bg7Sk46h5sO0Tfq3hsT_fwX0XJZ9g</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Flåøyen, A</creator><creator>Bratberg, B</creator><creator>Frøslie, A</creator><creator>Grønstøl, H</creator><creator>Langseth, W</creator><creator>Mantle, P G</creator><creator>von Krogh, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19971001</creationdate><title>Nephrotoxicity in goats caused by dosing with a water extract from the stems of Narthecium ossifragum plants</title><author>Flåøyen, A ; Bratberg, B ; Frøslie, A ; Grønstøl, H ; Langseth, W ; Mantle, P G ; von Krogh, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p237t-2f1b66d3ebd34b6d99ef72a620afed6755081b3a9ef7bcac9378c3023bde0e2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Calcium - blood</topic><topic>Creatinine - blood</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epithelium - drug effects</topic><topic>Epithelium - pathology</topic><topic>gamma-Glutamyltransferase - blood</topic><topic>Glutamate Dehydrogenase - blood</topic><topic>Goat Diseases - etiology</topic><topic>Goats</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidney - physiopathology</topic><topic>Liver - drug effects</topic><topic>Liver - pathology</topic><topic>Liver - physiopathology</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Lung - physiopathology</topic><topic>Magnesium - blood</topic><topic>Male</topic><topic>Necrosis</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - toxicity</topic><topic>Plant Poisoning - etiology</topic><topic>Plant Poisoning - veterinary</topic><topic>Plant Stems - chemistry</topic><topic>Time Factors</topic><topic>Urea - blood</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flåøyen, A</creatorcontrib><creatorcontrib>Bratberg, B</creatorcontrib><creatorcontrib>Frøslie, A</creatorcontrib><creatorcontrib>Grønstøl, H</creatorcontrib><creatorcontrib>Langseth, W</creatorcontrib><creatorcontrib>Mantle, P G</creatorcontrib><creatorcontrib>von Krogh, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Veterinary research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flåøyen, A</au><au>Bratberg, B</au><au>Frøslie, A</au><au>Grønstøl, H</au><au>Langseth, W</au><au>Mantle, P G</au><au>von Krogh, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nephrotoxicity in goats caused by dosing with a water extract from the stems of Narthecium ossifragum plants</atitle><jtitle>Veterinary research communications</jtitle><addtitle>Vet Res Commun</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>21</volume><issue>7</issue><spage>499</spage><epage>506</epage><pages>499-506</pages><issn>0165-7380</issn><abstract>Seven goats were given a single dose of an aqueous extract derived from 30 g (wet weight) of Narthecium ossifragum per kg liveweight. Their serum creatinine and urea concentrations increased to day 5 but then fell to normal by day 10. Serum magnesium increased to day 4 and decreased to normal by day 9. Their serum calcium concentration was lower than normal on days 4, 5 and 6. Histopathological examination of the kidneys of goats killed or found dead 2, 4, 6, 8, 11 or 16 days after dosing revealed tubular epithelial cell degeneration and necrosis. Regeneration of the tubular epithelium and signs of interstitial fibroplast proliferation and fibrosis could be seen in animals killed on days 8, 11, 16 and 42. No signs of liver damage were observed in 3 goats dosed with the insoluble plant material from 40 g (wet weight) Narthecium ossifragum per kg liveweight. The total dose was divided into three doses, which were given intraruminally within 7 h. The activities of aspartate aminotransferase, gamma-glutamyltransferase and glutamate dehydrogenase remained within the normal range in all 10 goats after dosing.</abstract><cop>Netherlands</cop><pmid>9345717</pmid><doi>10.1023/a:1005994421299</doi><tpages>8</tpages></addata></record> |
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| ispartof | Veterinary research communications, 1997-10, Vol.21 (7), p.499-506 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Aspartate Aminotransferases - blood Calcium - blood Creatinine - blood Dose-Response Relationship, Drug Epithelium - drug effects Epithelium - pathology gamma-Glutamyltransferase - blood Glutamate Dehydrogenase - blood Goat Diseases - etiology Goats Kidney - drug effects Kidney - pathology Kidney - physiopathology Liver - drug effects Liver - pathology Liver - physiopathology Lung - drug effects Lung - pathology Lung - physiopathology Magnesium - blood Male Necrosis Plant Extracts - analysis Plant Extracts - toxicity Plant Poisoning - etiology Plant Poisoning - veterinary Plant Stems - chemistry Time Factors Urea - blood Water |
| title | Nephrotoxicity in goats caused by dosing with a water extract from the stems of Narthecium ossifragum plants |
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