Maternal high‐protein or high‐prebiotic‐fiber diets affect maternal milk composition and gut microbiota in rat dams and their offspring
Objective Maternal gut microbiota and milk composition could modify offspring microbiota and therefore disease susceptibility. The effect of maternal high‐protein (HP) or prebiotic diets on maternal milk composition and gut microbiota in rat dams and offspring was examined. Methods Wistar rat dams w...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2014-11, Vol.22 (11), p.2344-2351 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Hallam, Megan C. Barile, Daniela Meyrand, Mickael German, J. Bruce Reimer, Raylene A. |
| description | Objective
Maternal gut microbiota and milk composition could modify offspring microbiota and therefore disease susceptibility. The effect of maternal high‐protein (HP) or prebiotic diets on maternal milk composition and gut microbiota in rat dams and offspring was examined.
Methods
Wistar rat dams were fed a control, HP (40% wt/wt), or high‐prebiotic‐fiber (21.6% wt/wt) (HF) diet throughout pregnancy and lactation. Pups were challenged with a high‐fat/sucrose diet from 14.5 to 22.5 weeks of age. Dam milk was analyzed for fat, protein, and oligosaccharides (OS). Fecal microbiota was analyzed in dams at parturition and 2 weeks post‐partum and in offspring at 5 and 22 weeks along with cecal digesta at termination.
Results
Maternal milk differed only in OS content, each diet group being distinguishable. HF1 and HP1 offspring had decreased plasma lipopolysaccharide compared with C1. Offspring sex, maternal diet, and time (5 weeks vs. 22 weeks of age) affected the microbial groups examined. Bifidobacteria was higher in HF dams and offspring.
Conclusions
Increasing protein or fiber content in maternal diet during pregnancy and lactation modifies milk OS content and gut microbiota of dams which may influence establishment of gut microbiota in offspring. |
| doi_str_mv | 10.1002/oby.20849 |
| format | Article |
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Maternal gut microbiota and milk composition could modify offspring microbiota and therefore disease susceptibility. The effect of maternal high‐protein (HP) or prebiotic diets on maternal milk composition and gut microbiota in rat dams and offspring was examined.
Methods
Wistar rat dams were fed a control, HP (40% wt/wt), or high‐prebiotic‐fiber (21.6% wt/wt) (HF) diet throughout pregnancy and lactation. Pups were challenged with a high‐fat/sucrose diet from 14.5 to 22.5 weeks of age. Dam milk was analyzed for fat, protein, and oligosaccharides (OS). Fecal microbiota was analyzed in dams at parturition and 2 weeks post‐partum and in offspring at 5 and 22 weeks along with cecal digesta at termination.
Results
Maternal milk differed only in OS content, each diet group being distinguishable. HF1 and HP1 offspring had decreased plasma lipopolysaccharide compared with C1. Offspring sex, maternal diet, and time (5 weeks vs. 22 weeks of age) affected the microbial groups examined. Bifidobacteria was higher in HF dams and offspring.
Conclusions
Increasing protein or fiber content in maternal diet during pregnancy and lactation modifies milk OS content and gut microbiota of dams which may influence establishment of gut microbiota in offspring.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20849</identifier><identifier>PMID: 25056822</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Animals, Newborn ; Breastfeeding & lactation ; Diet ; Dietary fiber ; Dietary Fiber - pharmacology ; Dietary Proteins - pharmacology ; Female ; Intestines - drug effects ; Intestines - microbiology ; Laboratory animals ; Lactation - drug effects ; Male ; Maternal Nutritional Physiological Phenomena - drug effects ; Metabolism ; Microbiota - drug effects ; Milk ; Milk - chemistry ; Milk - drug effects ; Prebiotics ; Pregnancy ; Proteins ; Rats ; Rats, Wistar ; Rodents ; Weaning</subject><ispartof>Obesity (Silver Spring, Md.), 2014-11, Vol.22 (11), p.2344-2351</ispartof><rights>2014 The Obesity Society</rights><rights>2014 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Nov 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3199-293f42659711913b11af30cd7bc8864acc7cf4fbe6646a782a6ab76d5ee2d8bb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20849$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20849$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25056822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hallam, Megan C.</creatorcontrib><creatorcontrib>Barile, Daniela</creatorcontrib><creatorcontrib>Meyrand, Mickael</creatorcontrib><creatorcontrib>German, J. Bruce</creatorcontrib><creatorcontrib>Reimer, Raylene A.</creatorcontrib><title>Maternal high‐protein or high‐prebiotic‐fiber diets affect maternal milk composition and gut microbiota in rat dams and their offspring</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Maternal gut microbiota and milk composition could modify offspring microbiota and therefore disease susceptibility. The effect of maternal high‐protein (HP) or prebiotic diets on maternal milk composition and gut microbiota in rat dams and offspring was examined.
Methods
Wistar rat dams were fed a control, HP (40% wt/wt), or high‐prebiotic‐fiber (21.6% wt/wt) (HF) diet throughout pregnancy and lactation. Pups were challenged with a high‐fat/sucrose diet from 14.5 to 22.5 weeks of age. Dam milk was analyzed for fat, protein, and oligosaccharides (OS). Fecal microbiota was analyzed in dams at parturition and 2 weeks post‐partum and in offspring at 5 and 22 weeks along with cecal digesta at termination.
Results
Maternal milk differed only in OS content, each diet group being distinguishable. HF1 and HP1 offspring had decreased plasma lipopolysaccharide compared with C1. Offspring sex, maternal diet, and time (5 weeks vs. 22 weeks of age) affected the microbial groups examined. Bifidobacteria was higher in HF dams and offspring.
Conclusions
Increasing protein or fiber content in maternal diet during pregnancy and lactation modifies milk OS content and gut microbiota of dams which may influence establishment of gut microbiota in offspring.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Breastfeeding & lactation</subject><subject>Diet</subject><subject>Dietary fiber</subject><subject>Dietary Fiber - pharmacology</subject><subject>Dietary Proteins - pharmacology</subject><subject>Female</subject><subject>Intestines - drug effects</subject><subject>Intestines - microbiology</subject><subject>Laboratory animals</subject><subject>Lactation - drug effects</subject><subject>Male</subject><subject>Maternal Nutritional Physiological Phenomena - drug effects</subject><subject>Metabolism</subject><subject>Microbiota - drug effects</subject><subject>Milk</subject><subject>Milk - chemistry</subject><subject>Milk - drug effects</subject><subject>Prebiotics</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Weaning</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctKxDAYhYMojreFLyABN246JmmbNksdvIHiRkFXJUmTmYxtMyYpMjtfQPAZfRLT8Qaucsj__QfOfwDYx2iMESLHVizHBJUZWwNbmKUoKVL2sP6rSzwC297PEcooyvEmGJEc5bQkZAu83fCgXMcbODPT2cfr-8LZoEwHrfv7UcLYYGTU2gjlYG1U8JBrrWSA7Y9Ba5onKG27sN4EYzvIuxpO-0gY6exgwWE0djzAmrd-NQ4zZRy0WvuFM910F2xo3ni19_3ugPvzs7vJZXJ9e3E1OblOZIoZSwhLdUZozgqMGU4FxlynSNaFkGVJMy5lIXWmhaI0o7woCadcFLTOlSJ1KUS6A46-fGPa5175ULXGS9U0vFO29xWmhKC4i4qIHv5D57Yf8g5UkTMcQRSpg2-qF62qq5im5W5Z_Rw6AsdfwItp1PJ3jlE1NFjFBqtVg9Xt6eNKpJ-qZZKn</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Hallam, Megan C.</creator><creator>Barile, Daniela</creator><creator>Meyrand, Mickael</creator><creator>German, J. Bruce</creator><creator>Reimer, Raylene A.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Maternal high‐protein or high‐prebiotic‐fiber diets affect maternal milk composition and gut microbiota in rat dams and their offspring</title><author>Hallam, Megan C. ; Barile, Daniela ; Meyrand, Mickael ; German, J. Bruce ; Reimer, Raylene A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3199-293f42659711913b11af30cd7bc8864acc7cf4fbe6646a782a6ab76d5ee2d8bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Breastfeeding & lactation</topic><topic>Diet</topic><topic>Dietary fiber</topic><topic>Dietary Fiber - pharmacology</topic><topic>Dietary Proteins - pharmacology</topic><topic>Female</topic><topic>Intestines - drug effects</topic><topic>Intestines - microbiology</topic><topic>Laboratory animals</topic><topic>Lactation - drug effects</topic><topic>Male</topic><topic>Maternal Nutritional Physiological Phenomena - drug effects</topic><topic>Metabolism</topic><topic>Microbiota - drug effects</topic><topic>Milk</topic><topic>Milk - chemistry</topic><topic>Milk - drug effects</topic><topic>Prebiotics</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hallam, Megan C.</creatorcontrib><creatorcontrib>Barile, Daniela</creatorcontrib><creatorcontrib>Meyrand, Mickael</creatorcontrib><creatorcontrib>German, J. Bruce</creatorcontrib><creatorcontrib>Reimer, Raylene A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hallam, Megan C.</au><au>Barile, Daniela</au><au>Meyrand, Mickael</au><au>German, J. Bruce</au><au>Reimer, Raylene A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal high‐protein or high‐prebiotic‐fiber diets affect maternal milk composition and gut microbiota in rat dams and their offspring</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2014-11</date><risdate>2014</risdate><volume>22</volume><issue>11</issue><spage>2344</spage><epage>2351</epage><pages>2344-2351</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Maternal gut microbiota and milk composition could modify offspring microbiota and therefore disease susceptibility. The effect of maternal high‐protein (HP) or prebiotic diets on maternal milk composition and gut microbiota in rat dams and offspring was examined.
Methods
Wistar rat dams were fed a control, HP (40% wt/wt), or high‐prebiotic‐fiber (21.6% wt/wt) (HF) diet throughout pregnancy and lactation. Pups were challenged with a high‐fat/sucrose diet from 14.5 to 22.5 weeks of age. Dam milk was analyzed for fat, protein, and oligosaccharides (OS). Fecal microbiota was analyzed in dams at parturition and 2 weeks post‐partum and in offspring at 5 and 22 weeks along with cecal digesta at termination.
Results
Maternal milk differed only in OS content, each diet group being distinguishable. HF1 and HP1 offspring had decreased plasma lipopolysaccharide compared with C1. Offspring sex, maternal diet, and time (5 weeks vs. 22 weeks of age) affected the microbial groups examined. Bifidobacteria was higher in HF dams and offspring.
Conclusions
Increasing protein or fiber content in maternal diet during pregnancy and lactation modifies milk OS content and gut microbiota of dams which may influence establishment of gut microbiota in offspring.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25056822</pmid><doi>10.1002/oby.20849</doi><tpages>8</tpages></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2014-11, Vol.22 (11), p.2344-2351 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content |
| subjects | Animals Animals, Newborn Breastfeeding & lactation Diet Dietary fiber Dietary Fiber - pharmacology Dietary Proteins - pharmacology Female Intestines - drug effects Intestines - microbiology Laboratory animals Lactation - drug effects Male Maternal Nutritional Physiological Phenomena - drug effects Metabolism Microbiota - drug effects Milk Milk - chemistry Milk - drug effects Prebiotics Pregnancy Proteins Rats Rats, Wistar Rodents Weaning |
| title | Maternal high‐protein or high‐prebiotic‐fiber diets affect maternal milk composition and gut microbiota in rat dams and their offspring |
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