One pot synthesis of pyrrolo[3,4-c]quinolinone/pyrrolo[3,4-c]quinoline derivatives from 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC)

One pot synthesis of pyrrolo[3,4-c]quinolinone/pyrrolo[3,4-c]quinoline derivatives from 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC)

An efficient and practical synthetic approach to access to 2H-pyrrolo[3,4-c]quinolin-4(5H)-one/2H-pyrrolo[3,4-c]quinoline derivatives by the reaction of 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC) via a one pot van Leusen reaction and cyclization under basic conditions...

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Veröffentlicht in:Organic & biomolecular chemistry 2014-12, Vol.12 (46), p.9471-9477
Hauptverfasser: Lu, Xin-Mou, Li, Jian, Cai, Zhong-Jian, Wang, Rong, Wang, Shun-Yi, Ji, Shun-Jun
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container_end_page 9477
container_issue 46
container_start_page 9471
container_title Organic & biomolecular chemistry
container_volume 12
creator Lu, Xin-Mou
Li, Jian
Cai, Zhong-Jian
Wang, Rong
Wang, Shun-Yi
Ji, Shun-Jun
description An efficient and practical synthetic approach to access to 2H-pyrrolo[3,4-c]quinolin-4(5H)-one/2H-pyrrolo[3,4-c]quinoline derivatives by the reaction of 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC) via a one pot van Leusen reaction and cyclization under basic conditions has been reported. The desired products could be obtained in moderate to good yields.
doi_str_mv 10.1039/c4ob01580k
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
title One pot synthesis of pyrrolo[3,4-c]quinolinone/pyrrolo[3,4-c]quinoline derivatives from 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC)
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