Vitamin D deficiency and its correction in children with sickle cell anaemia
Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA and to evaluate two methods of vitamin...
Gespeichert in:
| Veröffentlicht in: | Annals of hematology 2014-12, Vol.93 (12), p.2051-2056 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2056 |
|---|---|
| container_issue | 12 |
| container_start_page | 2051 |
| container_title | Annals of hematology |
| container_volume | 93 |
| creator | Wykes, Clare Arasaretnam, Anita O’Driscoll, Sandra Farnham, Laura Moniz, Caje Rees, David C. |
| description | Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA and to evaluate two methods of vitamin D supplementation. We audited 25-OHD levels in 81 children with SCA and looked for statistical associations with biochemical, haematological and clinical parameters. In a separate group of regularly transfused children with SCA, we compared changes in 25-OHD blood concentrations following treatment with either high-dose intramuscular ergocalciferol (
n
= 15) or 4 days of high-dose oral cholecalciferol (
n
= 64). Ninety-one percent of children with SCA had 25-OHD levels |
| doi_str_mv | 10.1007/s00277-014-2144-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1622058787</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1622058787</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-31dd36c29ab8c9aa3d0cce02b4d80a66ab2ae09e38cb75be71ea08987a8ea34e3</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMoWqs_wIsEvHhZnXx0kz1K_YSCF_Uastmpje5HTbZI_71ZWkUE5zKHeead4SHkhMEFA1CXEYArlQGTGWdSZmqHjJgUPIOJlrtkBIUoskmqA3IY4xsA41ryfXLAZaFZrosRmb343ja-pde0wrl3Hlu3pratqO8jdV0I6HrftTQhbuHrKmBLP32_oNG79xqpw7pOvMXG2yOyN7d1xONtH5Pn25un6X02e7x7mF7NMicl7zPBqkrkjhe21K6wVlTgHAIvZaXB5rktuUUoUGhXqkmJiqEFXWhlNVohUYzJ-SZ3GbqPFcbeND4Oj9gWu1U0LOc8KVBaJfTsD_rWrUKbvhsomAiVS5YotqFc6GIMODfL4Bsb1oaBGVSbjWqTVJtBtRmST7fJq7LB6mfj220C-AaIadS-Yvh1-t_UL3tjiLo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1620537641</pqid></control><display><type>article</type><title>Vitamin D deficiency and its correction in children with sickle cell anaemia</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Wykes, Clare ; Arasaretnam, Anita ; O’Driscoll, Sandra ; Farnham, Laura ; Moniz, Caje ; Rees, David C.</creator><creatorcontrib>Wykes, Clare ; Arasaretnam, Anita ; O’Driscoll, Sandra ; Farnham, Laura ; Moniz, Caje ; Rees, David C.</creatorcontrib><description>Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA and to evaluate two methods of vitamin D supplementation. We audited 25-OHD levels in 81 children with SCA and looked for statistical associations with biochemical, haematological and clinical parameters. In a separate group of regularly transfused children with SCA, we compared changes in 25-OHD blood concentrations following treatment with either high-dose intramuscular ergocalciferol (
n
= 15) or 4 days of high-dose oral cholecalciferol (
n
= 64). Ninety-one percent of children with SCA had 25-OHD levels <20 μg/L. The 25-OHD levels were negatively correlated with increasing age (
P
< 0.001) but showed no significant relationship to laboratory measurements, transcranial Doppler velocities or hospital attendance. Both intramuscular ergocalciferol and oral cholecalciferol supplementations resulted in increases of 25-OHD blood concentration to normal levels. The mean dose of ergocalciferol was greater than that of cholecalciferol (7,729 versus 5,234 international units (IU)/kg,
P
< 0.001), but the increment in 25-OHD levels was significantly greater in the oral cholecalciferol group (6.44 versus 2.82 (ng/L)/(IU/kg),
P
< 0.001). Both approaches resulted in vitamin D sufficiency for about 120 days. Increased 25-OHD concentration was significantly associated with increased serum calcium concentration. Vitamin D deficiency is very common in SCA and can be effectively corrected with high-dose intramuscular ergocalciferol or 4 days of high-dose oral cholecalciferol. Prospective, randomised studies are needed to assess the clinical value of vitamin D supplementation.</description><identifier>ISSN: 0939-5555</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-014-2144-7</identifier><identifier>PMID: 24981689</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Administration, Oral ; Alkaline Phosphatase - blood ; Anemia, Sickle Cell - blood ; Anemia, Sickle Cell - complications ; Blood Flow Velocity ; Calcifediol - blood ; Calcifediol - deficiency ; Calcium - blood ; Cerebrovascular Circulation ; Child ; Cholecalciferol - administration & dosage ; Cholecalciferol - therapeutic use ; Cross-Sectional Studies ; Ergocalciferols - administration & dosage ; Ergocalciferols - therapeutic use ; Female ; Hematology ; Hospitalization - statistics & numerical data ; Humans ; Injections, Intramuscular ; Male ; Medical Audit ; Medicine ; Medicine & Public Health ; Oncology ; Original Article ; Retrospective Studies ; Ultrasonography, Doppler, Transcranial ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - complications ; Vitamin D Deficiency - drug therapy</subject><ispartof>Annals of hematology, 2014-12, Vol.93 (12), p.2051-2056</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-31dd36c29ab8c9aa3d0cce02b4d80a66ab2ae09e38cb75be71ea08987a8ea34e3</citedby><cites>FETCH-LOGICAL-c442t-31dd36c29ab8c9aa3d0cce02b4d80a66ab2ae09e38cb75be71ea08987a8ea34e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00277-014-2144-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00277-014-2144-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24981689$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wykes, Clare</creatorcontrib><creatorcontrib>Arasaretnam, Anita</creatorcontrib><creatorcontrib>O’Driscoll, Sandra</creatorcontrib><creatorcontrib>Farnham, Laura</creatorcontrib><creatorcontrib>Moniz, Caje</creatorcontrib><creatorcontrib>Rees, David C.</creatorcontrib><title>Vitamin D deficiency and its correction in children with sickle cell anaemia</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA and to evaluate two methods of vitamin D supplementation. We audited 25-OHD levels in 81 children with SCA and looked for statistical associations with biochemical, haematological and clinical parameters. In a separate group of regularly transfused children with SCA, we compared changes in 25-OHD blood concentrations following treatment with either high-dose intramuscular ergocalciferol (
n
= 15) or 4 days of high-dose oral cholecalciferol (
n
= 64). Ninety-one percent of children with SCA had 25-OHD levels <20 μg/L. The 25-OHD levels were negatively correlated with increasing age (
P
< 0.001) but showed no significant relationship to laboratory measurements, transcranial Doppler velocities or hospital attendance. Both intramuscular ergocalciferol and oral cholecalciferol supplementations resulted in increases of 25-OHD blood concentration to normal levels. The mean dose of ergocalciferol was greater than that of cholecalciferol (7,729 versus 5,234 international units (IU)/kg,
P
< 0.001), but the increment in 25-OHD levels was significantly greater in the oral cholecalciferol group (6.44 versus 2.82 (ng/L)/(IU/kg),
P
< 0.001). Both approaches resulted in vitamin D sufficiency for about 120 days. Increased 25-OHD concentration was significantly associated with increased serum calcium concentration. Vitamin D deficiency is very common in SCA and can be effectively corrected with high-dose intramuscular ergocalciferol or 4 days of high-dose oral cholecalciferol. Prospective, randomised studies are needed to assess the clinical value of vitamin D supplementation.</description><subject>Administration, Oral</subject><subject>Alkaline Phosphatase - blood</subject><subject>Anemia, Sickle Cell - blood</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Blood Flow Velocity</subject><subject>Calcifediol - blood</subject><subject>Calcifediol - deficiency</subject><subject>Calcium - blood</subject><subject>Cerebrovascular Circulation</subject><subject>Child</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Cholecalciferol - therapeutic use</subject><subject>Cross-Sectional Studies</subject><subject>Ergocalciferols - administration & dosage</subject><subject>Ergocalciferols - therapeutic use</subject><subject>Female</subject><subject>Hematology</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Injections, Intramuscular</subject><subject>Male</subject><subject>Medical Audit</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Retrospective Studies</subject><subject>Ultrasonography, Doppler, Transcranial</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - complications</subject><subject>Vitamin D Deficiency - drug therapy</subject><issn>0939-5555</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMoWqs_wIsEvHhZnXx0kz1K_YSCF_Uastmpje5HTbZI_71ZWkUE5zKHeead4SHkhMEFA1CXEYArlQGTGWdSZmqHjJgUPIOJlrtkBIUoskmqA3IY4xsA41ryfXLAZaFZrosRmb343ja-pde0wrl3Hlu3pratqO8jdV0I6HrftTQhbuHrKmBLP32_oNG79xqpw7pOvMXG2yOyN7d1xONtH5Pn25un6X02e7x7mF7NMicl7zPBqkrkjhe21K6wVlTgHAIvZaXB5rktuUUoUGhXqkmJiqEFXWhlNVohUYzJ-SZ3GbqPFcbeND4Oj9gWu1U0LOc8KVBaJfTsD_rWrUKbvhsomAiVS5YotqFc6GIMODfL4Bsb1oaBGVSbjWqTVJtBtRmST7fJq7LB6mfj220C-AaIadS-Yvh1-t_UL3tjiLo</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Wykes, Clare</creator><creator>Arasaretnam, Anita</creator><creator>O’Driscoll, Sandra</creator><creator>Farnham, Laura</creator><creator>Moniz, Caje</creator><creator>Rees, David C.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>Vitamin D deficiency and its correction in children with sickle cell anaemia</title><author>Wykes, Clare ; Arasaretnam, Anita ; O’Driscoll, Sandra ; Farnham, Laura ; Moniz, Caje ; Rees, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-31dd36c29ab8c9aa3d0cce02b4d80a66ab2ae09e38cb75be71ea08987a8ea34e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Administration, Oral</topic><topic>Alkaline Phosphatase - blood</topic><topic>Anemia, Sickle Cell - blood</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Blood Flow Velocity</topic><topic>Calcifediol - blood</topic><topic>Calcifediol - deficiency</topic><topic>Calcium - blood</topic><topic>Cerebrovascular Circulation</topic><topic>Child</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Cholecalciferol - therapeutic use</topic><topic>Cross-Sectional Studies</topic><topic>Ergocalciferols - administration & dosage</topic><topic>Ergocalciferols - therapeutic use</topic><topic>Female</topic><topic>Hematology</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Injections, Intramuscular</topic><topic>Male</topic><topic>Medical Audit</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Retrospective Studies</topic><topic>Ultrasonography, Doppler, Transcranial</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - complications</topic><topic>Vitamin D Deficiency - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wykes, Clare</creatorcontrib><creatorcontrib>Arasaretnam, Anita</creatorcontrib><creatorcontrib>O’Driscoll, Sandra</creatorcontrib><creatorcontrib>Farnham, Laura</creatorcontrib><creatorcontrib>Moniz, Caje</creatorcontrib><creatorcontrib>Rees, David C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wykes, Clare</au><au>Arasaretnam, Anita</au><au>O’Driscoll, Sandra</au><au>Farnham, Laura</au><au>Moniz, Caje</au><au>Rees, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D deficiency and its correction in children with sickle cell anaemia</atitle><jtitle>Annals of hematology</jtitle><stitle>Ann Hematol</stitle><addtitle>Ann Hematol</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>93</volume><issue>12</issue><spage>2051</spage><epage>2056</epage><pages>2051-2056</pages><issn>0939-5555</issn><eissn>1432-0584</eissn><abstract>Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA and to evaluate two methods of vitamin D supplementation. We audited 25-OHD levels in 81 children with SCA and looked for statistical associations with biochemical, haematological and clinical parameters. In a separate group of regularly transfused children with SCA, we compared changes in 25-OHD blood concentrations following treatment with either high-dose intramuscular ergocalciferol (
n
= 15) or 4 days of high-dose oral cholecalciferol (
n
= 64). Ninety-one percent of children with SCA had 25-OHD levels <20 μg/L. The 25-OHD levels were negatively correlated with increasing age (
P
< 0.001) but showed no significant relationship to laboratory measurements, transcranial Doppler velocities or hospital attendance. Both intramuscular ergocalciferol and oral cholecalciferol supplementations resulted in increases of 25-OHD blood concentration to normal levels. The mean dose of ergocalciferol was greater than that of cholecalciferol (7,729 versus 5,234 international units (IU)/kg,
P
< 0.001), but the increment in 25-OHD levels was significantly greater in the oral cholecalciferol group (6.44 versus 2.82 (ng/L)/(IU/kg),
P
< 0.001). Both approaches resulted in vitamin D sufficiency for about 120 days. Increased 25-OHD concentration was significantly associated with increased serum calcium concentration. Vitamin D deficiency is very common in SCA and can be effectively corrected with high-dose intramuscular ergocalciferol or 4 days of high-dose oral cholecalciferol. Prospective, randomised studies are needed to assess the clinical value of vitamin D supplementation.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24981689</pmid><doi>10.1007/s00277-014-2144-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-5555 |
| ispartof | Annals of hematology, 2014-12, Vol.93 (12), p.2051-2056 |
| issn | 0939-5555 1432-0584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1622058787 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Administration, Oral Alkaline Phosphatase - blood Anemia, Sickle Cell - blood Anemia, Sickle Cell - complications Blood Flow Velocity Calcifediol - blood Calcifediol - deficiency Calcium - blood Cerebrovascular Circulation Child Cholecalciferol - administration & dosage Cholecalciferol - therapeutic use Cross-Sectional Studies Ergocalciferols - administration & dosage Ergocalciferols - therapeutic use Female Hematology Hospitalization - statistics & numerical data Humans Injections, Intramuscular Male Medical Audit Medicine Medicine & Public Health Oncology Original Article Retrospective Studies Ultrasonography, Doppler, Transcranial Vitamin D Deficiency - blood Vitamin D Deficiency - complications Vitamin D Deficiency - drug therapy |
| title | Vitamin D deficiency and its correction in children with sickle cell anaemia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T02%3A25%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitamin%20D%20deficiency%20and%20its%20correction%20in%20children%20with%20sickle%20cell%20anaemia&rft.jtitle=Annals%20of%20hematology&rft.au=Wykes,%20Clare&rft.date=2014-12-01&rft.volume=93&rft.issue=12&rft.spage=2051&rft.epage=2056&rft.pages=2051-2056&rft.issn=0939-5555&rft.eissn=1432-0584&rft_id=info:doi/10.1007/s00277-014-2144-7&rft_dat=%3Cproquest_cross%3E1622058787%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1620537641&rft_id=info:pmid/24981689&rfr_iscdi=true |