Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins
Intracortical injections of iron ions have been shown to induce recurrent seizures and epileptic discharges in the EEG. (-)-Epigallocatechin (EGC) and (-)-epigallocatechin-3-O-gallate (EGCG), isolated from green tea leaves, have been reported to prevent or diminish the occurrence of epileptic discha...
Gespeichert in:
| Veröffentlicht in: | Neurochemical research 1992-06, Vol.17 (6), p.585-590 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 590 |
|---|---|
| container_issue | 6 |
| container_start_page | 585 |
| container_title | Neurochemical research |
| container_volume | 17 |
| creator | KABUTO, H YOKOI, I MORI, A |
| description | Intracortical injections of iron ions have been shown to induce recurrent seizures and epileptic discharges in the EEG. (-)-Epigallocatechin (EGC) and (-)-epigallocatechin-3-O-gallate (EGCG), isolated from green tea leaves, have been reported to prevent or diminish the occurrence of epileptic discharges induced by iron ions, and to inhibit catechol-O-methyltransferase. Iron ions significantly increased DOPAC and HVA levels in the intrastriatal perfusate 140 and 180 minutes, respectively, after injection. EGC and EGCG inhibited the increases induced by iron ions. Furthermore, EGCG decreased the HVA level in the perfusate 200 minutes after injection whether or not iron ions were injected. Iron ions had no effect on the 5-HIAA level, and EGC and EGCG raised it. These results suggest that formation of an epileptic focus induced by iron ions might be accompanied by activation of dopaminergic neurons, and that EGC and EGCG inhibit that hyperactivity. |
| doi_str_mv | 10.1007/bf00968787 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16218988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16218988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-a72c312232fcd26a11062688ad14f4bff751af4342099e3ecc1c491baf79713c3</originalsourceid><addsrcrecordid>eNpFkD1PwzAURS0EKqWwsCNlQAyIgJ_t-GOEigJSEQuwRo5jC6PELnGCBL-eVC0w3ad3j-5wEDoGfAkYi6vKYay4FFLsoCkUguZcYbqLpphyllNQeB8dpPSO8YgTmKAJUMEZK6bo9TGGqFsfbNbaXlex8b1NF5nvYsh8qAdj6yxZ_z1067cOdda_2TF7b2L4HJo0npl1zpo-iy7rdQg-pEO053ST7NE2Z-hlcfs8v8-XT3cP8-tlbhgVfa4FMRQIocSZmnANgDnhUuoamGOVc6IA7RhlBCtlqTUGDFNQaSeUAGroDJ1tdldd_Bhs6svWJ2ObRgcbh1QCJyCVlCN4vgFNF1PqrCtXnW9191UCLtcSy5vFr8QRPtmuDlVr6390Y23sT7e9TkY3rtPB-PSHFURyBQX9AYmWeQ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16218988</pqid></control><display><type>article</type><title>Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>KABUTO, H ; YOKOI, I ; MORI, A</creator><creatorcontrib>KABUTO, H ; YOKOI, I ; MORI, A</creatorcontrib><description>Intracortical injections of iron ions have been shown to induce recurrent seizures and epileptic discharges in the EEG. (-)-Epigallocatechin (EGC) and (-)-epigallocatechin-3-O-gallate (EGCG), isolated from green tea leaves, have been reported to prevent or diminish the occurrence of epileptic discharges induced by iron ions, and to inhibit catechol-O-methyltransferase. Iron ions significantly increased DOPAC and HVA levels in the intrastriatal perfusate 140 and 180 minutes, respectively, after injection. EGC and EGCG inhibited the increases induced by iron ions. Furthermore, EGCG decreased the HVA level in the perfusate 200 minutes after injection whether or not iron ions were injected. Iron ions had no effect on the 5-HIAA level, and EGC and EGCG raised it. These results suggest that formation of an epileptic focus induced by iron ions might be accompanied by activation of dopaminergic neurons, and that EGC and EGCG inhibit that hyperactivity.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/bf00968787</identifier><identifier>PMID: 1376445</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>3,4-Dihydroxyphenylacetic Acid - metabolism ; Animals ; Anticonvulsants - pharmacology ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biogenic Monoamines - metabolism ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Catechin - analogs & derivatives ; Catechin - pharmacology ; Chlorides ; Epilepsy - chemically induced ; Ferric Compounds - toxicity ; Flavonoids - administration & dosage ; Flavonoids - pharmacology ; Homovanillic Acid - metabolism ; Hydroxyindoleacetic Acid - metabolism ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains</subject><ispartof>Neurochemical research, 1992-06, Vol.17 (6), p.585-590</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-a72c312232fcd26a11062688ad14f4bff751af4342099e3ecc1c491baf79713c3</citedby><cites>FETCH-LOGICAL-c437t-a72c312232fcd26a11062688ad14f4bff751af4342099e3ecc1c491baf79713c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23928,23929,25138,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5286915$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1376445$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KABUTO, H</creatorcontrib><creatorcontrib>YOKOI, I</creatorcontrib><creatorcontrib>MORI, A</creatorcontrib><title>Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>Intracortical injections of iron ions have been shown to induce recurrent seizures and epileptic discharges in the EEG. (-)-Epigallocatechin (EGC) and (-)-epigallocatechin-3-O-gallate (EGCG), isolated from green tea leaves, have been reported to prevent or diminish the occurrence of epileptic discharges induced by iron ions, and to inhibit catechol-O-methyltransferase. Iron ions significantly increased DOPAC and HVA levels in the intrastriatal perfusate 140 and 180 minutes, respectively, after injection. EGC and EGCG inhibited the increases induced by iron ions. Furthermore, EGCG decreased the HVA level in the perfusate 200 minutes after injection whether or not iron ions were injected. Iron ions had no effect on the 5-HIAA level, and EGC and EGCG raised it. These results suggest that formation of an epileptic focus induced by iron ions might be accompanied by activation of dopaminergic neurons, and that EGC and EGCG inhibit that hyperactivity.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biogenic Monoamines - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - pharmacology</subject><subject>Chlorides</subject><subject>Epilepsy - chemically induced</subject><subject>Ferric Compounds - toxicity</subject><subject>Flavonoids - administration & dosage</subject><subject>Flavonoids - pharmacology</subject><subject>Homovanillic Acid - metabolism</subject><subject>Hydroxyindoleacetic Acid - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAURS0EKqWwsCNlQAyIgJ_t-GOEigJSEQuwRo5jC6PELnGCBL-eVC0w3ad3j-5wEDoGfAkYi6vKYay4FFLsoCkUguZcYbqLpphyllNQeB8dpPSO8YgTmKAJUMEZK6bo9TGGqFsfbNbaXlex8b1NF5nvYsh8qAdj6yxZ_z1067cOdda_2TF7b2L4HJo0npl1zpo-iy7rdQg-pEO053ST7NE2Z-hlcfs8v8-XT3cP8-tlbhgVfa4FMRQIocSZmnANgDnhUuoamGOVc6IA7RhlBCtlqTUGDFNQaSeUAGroDJ1tdldd_Bhs6svWJ2ObRgcbh1QCJyCVlCN4vgFNF1PqrCtXnW9191UCLtcSy5vFr8QRPtmuDlVr6390Y23sT7e9TkY3rtPB-PSHFURyBQX9AYmWeQ4</recordid><startdate>19920601</startdate><enddate>19920601</enddate><creator>KABUTO, H</creator><creator>YOKOI, I</creator><creator>MORI, A</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19920601</creationdate><title>Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins</title><author>KABUTO, H ; YOKOI, I ; MORI, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-a72c312232fcd26a11062688ad14f4bff751af4342099e3ecc1c491baf79713c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biogenic Monoamines - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Catechin - analogs & derivatives</topic><topic>Catechin - pharmacology</topic><topic>Chlorides</topic><topic>Epilepsy - chemically induced</topic><topic>Ferric Compounds - toxicity</topic><topic>Flavonoids - administration & dosage</topic><topic>Flavonoids - pharmacology</topic><topic>Homovanillic Acid - metabolism</topic><topic>Hydroxyindoleacetic Acid - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KABUTO, H</creatorcontrib><creatorcontrib>YOKOI, I</creatorcontrib><creatorcontrib>MORI, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KABUTO, H</au><au>YOKOI, I</au><au>MORI, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>1992-06-01</date><risdate>1992</risdate><volume>17</volume><issue>6</issue><spage>585</spage><epage>590</epage><pages>585-590</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><coden>NEREDZ</coden><abstract>Intracortical injections of iron ions have been shown to induce recurrent seizures and epileptic discharges in the EEG. (-)-Epigallocatechin (EGC) and (-)-epigallocatechin-3-O-gallate (EGCG), isolated from green tea leaves, have been reported to prevent or diminish the occurrence of epileptic discharges induced by iron ions, and to inhibit catechol-O-methyltransferase. Iron ions significantly increased DOPAC and HVA levels in the intrastriatal perfusate 140 and 180 minutes, respectively, after injection. EGC and EGCG inhibited the increases induced by iron ions. Furthermore, EGCG decreased the HVA level in the perfusate 200 minutes after injection whether or not iron ions were injected. Iron ions had no effect on the 5-HIAA level, and EGC and EGCG raised it. These results suggest that formation of an epileptic focus induced by iron ions might be accompanied by activation of dopaminergic neurons, and that EGC and EGCG inhibit that hyperactivity.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>1376445</pmid><doi>10.1007/bf00968787</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 1992-06, Vol.17 (6), p.585-590 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16218988 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Animals Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Biogenic Monoamines - metabolism Biological and medical sciences Brain - drug effects Brain - metabolism Catechin - analogs & derivatives Catechin - pharmacology Chlorides Epilepsy - chemically induced Ferric Compounds - toxicity Flavonoids - administration & dosage Flavonoids - pharmacology Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains |
| title | Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T19%3A40%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Monoamine%20metabolites,%20iron%20induced%20seizures,%20and%20the%20anticonvulsant%20effect%20of%20tannins&rft.jtitle=Neurochemical%20research&rft.au=KABUTO,%20H&rft.date=1992-06-01&rft.volume=17&rft.issue=6&rft.spage=585&rft.epage=590&rft.pages=585-590&rft.issn=0364-3190&rft.eissn=1573-6903&rft.coden=NEREDZ&rft_id=info:doi/10.1007/bf00968787&rft_dat=%3Cproquest_cross%3E16218988%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16218988&rft_id=info:pmid/1376445&rfr_iscdi=true |