Effect of Lung Irradiation on Mice following Paraquat Intoxication
To determine the effect of lung irradiation in mice with paraquat poisoning and whether irradiation could prevent lung destruction, we found the the lethal dose for 50 percent survival (LD50) in 50 mice (Swiss strain) was 25 mg/kg of body weight. The first control group comprised 15 mice and their l...
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| Veröffentlicht in: | Chest 1992-03, Vol.101 (3), p.833-835 |
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| container_title | Chest |
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| creator | Saenghirunvattana, Sawang Sermswan, Anawat Piratchvej, Virat Rochanawutanon, Mana Kaojarern, Strung Rattananenya, Tharathorn |
| description | To determine the effect of lung irradiation in mice with paraquat poisoning and whether irradiation could prevent lung destruction, we found the the lethal dose for 50 percent survival (LD50) in 50 mice (Swiss strain) was 25 mg/kg of body weight. The first control group comprised 15 mice and their lungs were irradiated with 200 rad for seven days. There was no death within six weeks. The lungs at autopsy appeared mildly congested. The control group comprised 15 mice. They were injected with 25 mg/kg of paraquat. Six died within three days. The experimental group included 14 mice injected with paraquat and with lung irradiation. Eight died within three days (p>0.5). The pathologic findings in the experimental group revealed lung congestion and fibrosis that was more pronounced than in the group that received only paraquat. We conclude that radiotherapy is not effective in amelioration of paraquat-induced lung damage in mice. |
| doi_str_mv | 10.1378/chest.101.3.833 |
| format | Article |
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The first control group comprised 15 mice and their lungs were irradiated with 200 rad for seven days. There was no death within six weeks. The lungs at autopsy appeared mildly congested. The control group comprised 15 mice. They were injected with 25 mg/kg of paraquat. Six died within three days. The experimental group included 14 mice injected with paraquat and with lung irradiation. Eight died within three days (p>0.5). The pathologic findings in the experimental group revealed lung congestion and fibrosis that was more pronounced than in the group that received only paraquat. We conclude that radiotherapy is not effective in amelioration of paraquat-induced lung damage in mice.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.101.3.833</identifier><identifier>PMID: 1541153</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Diseases of the respiratory system ; Lung - pathology ; Lung - radiation effects ; Medical sciences ; Mice ; Paraquat - toxicity ; Poisoning - pathology ; Poisoning - radiotherapy ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><ispartof>Chest, 1992-03, Vol.101 (3), p.833-835</ispartof><rights>1992 The American College of Chest Physicians</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-35e6f0fbe2431af238ee22ecb6baa23a404e2f77ec0894624dfca1f25b45ef1f3</citedby><cites>FETCH-LOGICAL-c442t-35e6f0fbe2431af238ee22ecb6baa23a404e2f77ec0894624dfca1f25b45ef1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4663022$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1541153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saenghirunvattana, Sawang</creatorcontrib><creatorcontrib>Sermswan, Anawat</creatorcontrib><creatorcontrib>Piratchvej, Virat</creatorcontrib><creatorcontrib>Rochanawutanon, Mana</creatorcontrib><creatorcontrib>Kaojarern, Strung</creatorcontrib><creatorcontrib>Rattananenya, Tharathorn</creatorcontrib><title>Effect of Lung Irradiation on Mice following Paraquat Intoxication</title><title>Chest</title><addtitle>Chest</addtitle><description>To determine the effect of lung irradiation in mice with paraquat poisoning and whether irradiation could prevent lung destruction, we found the the lethal dose for 50 percent survival (LD50) in 50 mice (Swiss strain) was 25 mg/kg of body weight. The first control group comprised 15 mice and their lungs were irradiated with 200 rad for seven days. There was no death within six weeks. The lungs at autopsy appeared mildly congested. The control group comprised 15 mice. They were injected with 25 mg/kg of paraquat. Six died within three days. The experimental group included 14 mice injected with paraquat and with lung irradiation. Eight died within three days (p>0.5). The pathologic findings in the experimental group revealed lung congestion and fibrosis that was more pronounced than in the group that received only paraquat. We conclude that radiotherapy is not effective in amelioration of paraquat-induced lung damage in mice.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diseases of the respiratory system</subject><subject>Lung - pathology</subject><subject>Lung - radiation effects</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Paraquat - toxicity</subject><subject>Poisoning - pathology</subject><subject>Poisoning - radiotherapy</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. 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Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saenghirunvattana, Sawang</creatorcontrib><creatorcontrib>Sermswan, Anawat</creatorcontrib><creatorcontrib>Piratchvej, Virat</creatorcontrib><creatorcontrib>Rochanawutanon, Mana</creatorcontrib><creatorcontrib>Kaojarern, Strung</creatorcontrib><creatorcontrib>Rattananenya, Tharathorn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saenghirunvattana, Sawang</au><au>Sermswan, Anawat</au><au>Piratchvej, Virat</au><au>Rochanawutanon, Mana</au><au>Kaojarern, Strung</au><au>Rattananenya, Tharathorn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Lung Irradiation on Mice following Paraquat Intoxication</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>101</volume><issue>3</issue><spage>833</spage><epage>835</epage><pages>833-835</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>To determine the effect of lung irradiation in mice with paraquat poisoning and whether irradiation could prevent lung destruction, we found the the lethal dose for 50 percent survival (LD50) in 50 mice (Swiss strain) was 25 mg/kg of body weight. 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| ispartof | Chest, 1992-03, Vol.101 (3), p.833-835 |
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| subjects | Animals Biological and medical sciences Diseases of the respiratory system Lung - pathology Lung - radiation effects Medical sciences Mice Paraquat - toxicity Poisoning - pathology Poisoning - radiotherapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) |
| title | Effect of Lung Irradiation on Mice following Paraquat Intoxication |
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