Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons
Spontaneous motor activity was measured in six baboons during chronic oral dosing with a diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Piezoelectric monitors sensitive to movement were attached to leather collars and were worn...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1992-03, Vol.41 (3), p.567-572 |
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| container_end_page | 572 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Turkkan, Jaylan S. Allen, Richard P. Hienz, Robert D. |
| description | Spontaneous motor activity was measured in six baboons during chronic oral dosing with a diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Piezoelectric monitors sensitive to movement were attached to leather collars and were worn continuously by the baboons throughout the protocol. Baboons were made hypertensive during a preexperimental period by either 1) chronic administration of deoxycorticosterone acetate (DOCA)-salt or 2) surgical renal artery stenosis. Total inactive periods/day increased over baseline levels during diuretic alone and increased further during diuretic + verapamil combined. The total number of inactive periods/day returned toward baseline levels in the subsequent conditions of verapamil alone and baseline recovery. Activity levels decreased during combination dosing mainly during morning hours (0700–1100 h). Overall changes in activity occurred in the second week of dosing; this time period was found earlier to maximally decrease blood pressure and to impair behavioral performances. |
| doi_str_mv | 10.1016/0091-3057(92)90374-O |
| format | Article |
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Piezoelectric monitors sensitive to movement were attached to leather collars and were worn continuously by the baboons throughout the protocol. Baboons were made hypertensive during a preexperimental period by either 1) chronic administration of deoxycorticosterone acetate (DOCA)-salt or 2) surgical renal artery stenosis. Total inactive periods/day increased over baseline levels during diuretic alone and increased further during diuretic + verapamil combined. The total number of inactive periods/day returned toward baseline levels in the subsequent conditions of verapamil alone and baseline recovery. Activity levels decreased during combination dosing mainly during morning hours (0700–1100 h). Overall changes in activity occurred in the second week of dosing; this time period was found earlier to maximally decrease blood pressure and to impair behavioral performances.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(92)90374-O</identifier><identifier>PMID: 1584836</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adverse side effects ; Animals ; Antihypertensive agents ; Baboons ; Berapamil ; Biological and medical sciences ; Blood pressure ; Blood Pressure - drug effects ; Calcium channel blocking agents ; DOCA-salt hypertension ; Drug Interactions ; Drug toxicity and drugs side effects treatment ; Hydrochlorothiazide ; Hydrochlorothiazide - administration & dosage ; Hydrochlorothiazide - toxicity ; Hypertension - drug therapy ; Hypertension - physiopathology ; Hypertension - psychology ; Male ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Motor Activity - drug effects ; Motor behavior ; Nonhuman primates ; Papio ; Papio anubis ; Papio cynocephalus ; Pharmacology. Drug treatments ; Renovascular hypertension ; Thiazide diuretics ; Verapamil - administration & dosage ; Verapamil - toxicity</subject><ispartof>Pharmacology, biochemistry and behavior, 1992-03, Vol.41 (3), p.567-572</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-cc519d3b13c5f85ddcaa5b22957ed2fa8d7f50dabf7927b9a554c627762ac6943</citedby><cites>FETCH-LOGICAL-c417t-cc519d3b13c5f85ddcaa5b22957ed2fa8d7f50dabf7927b9a554c627762ac6943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/009130579290374O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5280397$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1584836$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turkkan, Jaylan S.</creatorcontrib><creatorcontrib>Allen, Richard P.</creatorcontrib><creatorcontrib>Hienz, Robert D.</creatorcontrib><title>Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Spontaneous motor activity was measured in six baboons during chronic oral dosing with a diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Piezoelectric monitors sensitive to movement were attached to leather collars and were worn continuously by the baboons throughout the protocol. Baboons were made hypertensive during a preexperimental period by either 1) chronic administration of deoxycorticosterone acetate (DOCA)-salt or 2) surgical renal artery stenosis. Total inactive periods/day increased over baseline levels during diuretic alone and increased further during diuretic + verapamil combined. The total number of inactive periods/day returned toward baseline levels in the subsequent conditions of verapamil alone and baseline recovery. Activity levels decreased during combination dosing mainly during morning hours (0700–1100 h). Overall changes in activity occurred in the second week of dosing; this time period was found earlier to maximally decrease blood pressure and to impair behavioral performances.</description><subject>Adverse side effects</subject><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Baboons</subject><subject>Berapamil</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium channel blocking agents</subject><subject>DOCA-salt hypertension</subject><subject>Drug Interactions</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Hydrochlorothiazide</subject><subject>Hydrochlorothiazide - administration & dosage</subject><subject>Hydrochlorothiazide - toxicity</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Motor Activity - drug effects</subject><subject>Motor behavior</subject><subject>Nonhuman primates</subject><subject>Papio</subject><subject>Papio anubis</subject><subject>Papio cynocephalus</subject><subject>Pharmacology. Drug treatments</subject><subject>Renovascular hypertension</subject><subject>Thiazide diuretics</subject><subject>Verapamil - administration & dosage</subject><subject>Verapamil - toxicity</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVJSNy0b9CADiG0h00l7Wq1uhSKaZtCwJfk1IOYlUZYZVdypbXBffqsa5PeMpc5zPf_DB8hHzi744y3nxnTvKqZVB-1-KRZrZpq9YYseKfqSnKlzsjiBbkkb0v5zRhrRKsuyAWXXdPV7YL8Wq5zisHS9d7lZNdDymlaB_gbHFKIju4wwwbGMFD0Hu1UaIp0TFPKFOwUdmHa0xDn-AbzhLGEHdIe-pRieUfOPQwF35_2FXn6_u1xeV89rH78XH59qGzD1VRZK7l2dc9rK30nnbMAshdCS4VOeOic8pI56L3SQvUapGxsK5RqBdhWN_UVuT32bnL6s8UymTEUi8MAEdO2GN4KPo-cweYI2pxKyejNJocR8t5wZg5OzUGYOQgzWph_Ts1qjl2f-rf9iO5_6Chxvt-c7lAsDD5DtKG8YFJ0rNZqxr4cMZxd7AJmU2zAaNGFPIs1LoXX_3gGJaSUvw</recordid><startdate>19920301</startdate><enddate>19920301</enddate><creator>Turkkan, Jaylan S.</creator><creator>Allen, Richard P.</creator><creator>Hienz, Robert D.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19920301</creationdate><title>Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons</title><author>Turkkan, Jaylan S. ; Allen, Richard P. ; Hienz, Robert D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-cc519d3b13c5f85ddcaa5b22957ed2fa8d7f50dabf7927b9a554c627762ac6943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adverse side effects</topic><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Baboons</topic><topic>Berapamil</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Calcium channel blocking agents</topic><topic>DOCA-salt hypertension</topic><topic>Drug Interactions</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Hydrochlorothiazide</topic><topic>Hydrochlorothiazide - administration & dosage</topic><topic>Hydrochlorothiazide - toxicity</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Motor Activity - drug effects</topic><topic>Motor behavior</topic><topic>Nonhuman primates</topic><topic>Papio</topic><topic>Papio anubis</topic><topic>Papio cynocephalus</topic><topic>Pharmacology. Drug treatments</topic><topic>Renovascular hypertension</topic><topic>Thiazide diuretics</topic><topic>Verapamil - administration & dosage</topic><topic>Verapamil - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turkkan, Jaylan S.</creatorcontrib><creatorcontrib>Allen, Richard P.</creatorcontrib><creatorcontrib>Hienz, Robert D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Turkkan, Jaylan S.</au><au>Allen, Richard P.</au><au>Hienz, Robert D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>41</volume><issue>3</issue><spage>567</spage><epage>572</epage><pages>567-572</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Spontaneous motor activity was measured in six baboons during chronic oral dosing with a diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Piezoelectric monitors sensitive to movement were attached to leather collars and were worn continuously by the baboons throughout the protocol. Baboons were made hypertensive during a preexperimental period by either 1) chronic administration of deoxycorticosterone acetate (DOCA)-salt or 2) surgical renal artery stenosis. Total inactive periods/day increased over baseline levels during diuretic alone and increased further during diuretic + verapamil combined. The total number of inactive periods/day returned toward baseline levels in the subsequent conditions of verapamil alone and baseline recovery. Activity levels decreased during combination dosing mainly during morning hours (0700–1100 h). Overall changes in activity occurred in the second week of dosing; this time period was found earlier to maximally decrease blood pressure and to impair behavioral performances.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1584836</pmid><doi>10.1016/0091-3057(92)90374-O</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adverse side effects Animals Antihypertensive agents Baboons Berapamil Biological and medical sciences Blood pressure Blood Pressure - drug effects Calcium channel blocking agents DOCA-salt hypertension Drug Interactions Drug toxicity and drugs side effects treatment Hydrochlorothiazide Hydrochlorothiazide - administration & dosage Hydrochlorothiazide - toxicity Hypertension - drug therapy Hypertension - physiopathology Hypertension - psychology Male Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Motor Activity - drug effects Motor behavior Nonhuman primates Papio Papio anubis Papio cynocephalus Pharmacology. Drug treatments Renovascular hypertension Thiazide diuretics Verapamil - administration & dosage Verapamil - toxicity |
| title | Chronic hydrochlorothiazide and verapamil effects on motor activity in hypertensive baboons |
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