ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
p21 c- ras plays a critical role in mediating tyrosine kinase-stimulated cell growth and differentiation. However, the pathways through which p21 c- ras propagates these signals remain unknown. We report that in PC12 cells, expression of a dominant inhibitory mutant of ras, c-Ha- ras(Asn-17), antago...
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| Veröffentlicht in: | Cell 1992-03, Vol.68 (6), p.1041-1050 |
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| container_title | Cell |
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| creator | Wood, Kenneth W. Sarnecki, Charlyn Roberts, Thomas M. Blenis, John |
| description | p21
c-
ras
plays a critical role in mediating tyrosine kinase-stimulated cell growth and differentiation. However, the pathways through which p21
c-
ras
propagates these signals remain unknown. We report that in PC12 cells, expression of a dominant inhibitory mutant of
ras, c-Ha-
ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the
erk-encoded family of MAP kinases, the 85–92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1. In addition, we find that expression of the activated
ras oncogene is sufficient to stimulate these events. These data indicate that
ras mediates nerve growth factor receptor and protein kinase C modulation of MAP kinases, RSKs, and Raf-1. |
| doi_str_mv | 10.1016/0092-8674(92)90076-O |
| format | Article |
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c-
ras
plays a critical role in mediating tyrosine kinase-stimulated cell growth and differentiation. However, the pathways through which p21
c-
ras
propagates these signals remain unknown. We report that in PC12 cells, expression of a dominant inhibitory mutant of
ras, c-Ha-
ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the
erk-encoded family of MAP kinases, the 85–92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1. In addition, we find that expression of the activated
ras oncogene is sufficient to stimulate these events. These data indicate that
ras mediates nerve growth factor receptor and protein kinase C modulation of MAP kinases, RSKs, and Raf-1.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(92)90076-O</identifier><identifier>PMID: 1312393</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Calcium-Calmodulin-Dependent Protein Kinases ; Cell Line ; Gene Expression Regulation ; Genes, ras ; Genes, Regulator ; interaction ; MAP kinase ; nerve growth factor ; Nerve Growth Factors - pharmacology ; PC12 Cells - drug effects ; pheochromocytoma cells ; Phorbol Esters - pharmacology ; Phosphorylation - drug effects ; protein kinase C ; Protein Kinase C - metabolism ; Protein Kinases - metabolism ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-raf ; Proto-Oncogene Proteins p21(ras) ; raf-1 ; Raf-1 protein ; ras ; Ras protein ; rats ; receptors ; Receptors, Cell Surface - drug effects ; Receptors, Cell Surface - metabolism ; Receptors, Nerve Growth Factor ; requirements ; Ribosomal Protein S6 Kinases ; RSK protein ; Signal Transduction</subject><ispartof>Cell, 1992-03, Vol.68 (6), p.1041-1050</ispartof><rights>1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-2977cc6bf3737326fb159d61c331f1994286dcd97f0e9b6830f5c226df581af63</citedby><cites>FETCH-LOGICAL-c369t-2977cc6bf3737326fb159d61c331f1994286dcd97f0e9b6830f5c226df581af63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(92)90076-O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1312393$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, Kenneth W.</creatorcontrib><creatorcontrib>Sarnecki, Charlyn</creatorcontrib><creatorcontrib>Roberts, Thomas M.</creatorcontrib><creatorcontrib>Blenis, John</creatorcontrib><title>ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK</title><title>Cell</title><addtitle>Cell</addtitle><description>p21
c-
ras
plays a critical role in mediating tyrosine kinase-stimulated cell growth and differentiation. However, the pathways through which p21
c-
ras
propagates these signals remain unknown. We report that in PC12 cells, expression of a dominant inhibitory mutant of
ras, c-Ha-
ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the
erk-encoded family of MAP kinases, the 85–92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1. In addition, we find that expression of the activated
ras oncogene is sufficient to stimulate these events. These data indicate that
ras mediates nerve growth factor receptor and protein kinase C modulation of MAP kinases, RSKs, and Raf-1.</description><subject>Animals</subject><subject>Calcium-Calmodulin-Dependent Protein Kinases</subject><subject>Cell Line</subject><subject>Gene Expression Regulation</subject><subject>Genes, ras</subject><subject>Genes, Regulator</subject><subject>interaction</subject><subject>MAP kinase</subject><subject>nerve growth factor</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>PC12 Cells - drug effects</subject><subject>pheochromocytoma cells</subject><subject>Phorbol Esters - pharmacology</subject><subject>Phosphorylation - drug effects</subject><subject>protein kinase C</subject><subject>Protein Kinase C - metabolism</subject><subject>Protein Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-raf</subject><subject>Proto-Oncogene Proteins p21(ras)</subject><subject>raf-1</subject><subject>Raf-1 protein</subject><subject>ras</subject><subject>Ras protein</subject><subject>rats</subject><subject>receptors</subject><subject>Receptors, Cell Surface - drug effects</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Nerve Growth Factor</subject><subject>requirements</subject><subject>Ribosomal Protein S6 Kinases</subject><subject>RSK protein</subject><subject>Signal Transduction</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1rVDEQhoNY6lr9Bwq5kgo9Nh97khMvCqXYWqysVL0O2WSyjZ5N1iSnIvjjm3UXvZO5mBnmna8HoReUvKGEilNCFOsGIefHir1WhEjRLR6hGSVKdnMq2WM0-yt5gp6W8o0QMvR9f4gOKaeMKz5Dv7MpeA0umAoFR8j3gFc5_ax32BtbU8YZLGy2wTq5aTQ1pIiTx_UuA-ASVtGMXc0mFjfZEFd4k1OFEPH3EE2B8hZ_PP-0T07wrfEdPcEmOnz7-cMzdODNWOD53h-hr5fvvly8724WV9cX5zed5ULVjikprRVLz2UzJvyS9soJajmnnio1Z4Nw1inpCailGDjxvWVMON8P1HjBj9Cr3dx2248JStXrUCyMo4mQpqKpYJRIQppwvhPanErJ4PUmh7XJvzQlegtdb4nqLVHd_B_oetHaXu7nT8vG8l_TjnKrn-3q0J68D5B1sQGibdgb3apdCv9f8ADx9ZFA</recordid><startdate>19920320</startdate><enddate>19920320</enddate><creator>Wood, Kenneth W.</creator><creator>Sarnecki, Charlyn</creator><creator>Roberts, Thomas M.</creator><creator>Blenis, John</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>19920320</creationdate><title>ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK</title><author>Wood, Kenneth W. ; Sarnecki, Charlyn ; Roberts, Thomas M. ; Blenis, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-2977cc6bf3737326fb159d61c331f1994286dcd97f0e9b6830f5c226df581af63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Calcium-Calmodulin-Dependent Protein Kinases</topic><topic>Cell Line</topic><topic>Gene Expression Regulation</topic><topic>Genes, ras</topic><topic>Genes, Regulator</topic><topic>interaction</topic><topic>MAP kinase</topic><topic>nerve growth factor</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>PC12 Cells - drug effects</topic><topic>pheochromocytoma cells</topic><topic>Phorbol Esters - pharmacology</topic><topic>Phosphorylation - drug effects</topic><topic>protein kinase C</topic><topic>Protein Kinase C - metabolism</topic><topic>Protein Kinases - metabolism</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-raf</topic><topic>Proto-Oncogene Proteins p21(ras)</topic><topic>raf-1</topic><topic>Raf-1 protein</topic><topic>ras</topic><topic>Ras protein</topic><topic>rats</topic><topic>receptors</topic><topic>Receptors, Cell Surface - drug effects</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Nerve Growth Factor</topic><topic>requirements</topic><topic>Ribosomal Protein S6 Kinases</topic><topic>RSK protein</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, Kenneth W.</creatorcontrib><creatorcontrib>Sarnecki, Charlyn</creatorcontrib><creatorcontrib>Roberts, Thomas M.</creatorcontrib><creatorcontrib>Blenis, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, Kenneth W.</au><au>Sarnecki, Charlyn</au><au>Roberts, Thomas M.</au><au>Blenis, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1992-03-20</date><risdate>1992</risdate><volume>68</volume><issue>6</issue><spage>1041</spage><epage>1050</epage><pages>1041-1050</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>p21
c-
ras
plays a critical role in mediating tyrosine kinase-stimulated cell growth and differentiation. However, the pathways through which p21
c-
ras
propagates these signals remain unknown. We report that in PC12 cells, expression of a dominant inhibitory mutant of
ras, c-Ha-
ras(Asn-17), antagonizes growth factor- and phorbol ester-induced activation of the
erk-encoded family of MAP kinases, the 85–92 kd RSKs, and the kinase(s) responsible for hyperphosphorylation of the proto-oncogene product Raf-1. In addition, we find that expression of the activated
ras oncogene is sufficient to stimulate these events. These data indicate that
ras mediates nerve growth factor receptor and protein kinase C modulation of MAP kinases, RSKs, and Raf-1.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1312393</pmid><doi>10.1016/0092-8674(92)90076-O</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 1992-03, Vol.68 (6), p.1041-1050 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16210700 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Calcium-Calmodulin-Dependent Protein Kinases Cell Line Gene Expression Regulation Genes, ras Genes, Regulator interaction MAP kinase nerve growth factor Nerve Growth Factors - pharmacology PC12 Cells - drug effects pheochromocytoma cells Phorbol Esters - pharmacology Phosphorylation - drug effects protein kinase C Protein Kinase C - metabolism Protein Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-raf Proto-Oncogene Proteins p21(ras) raf-1 Raf-1 protein ras Ras protein rats receptors Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Nerve Growth Factor requirements Ribosomal Protein S6 Kinases RSK protein Signal Transduction |
| title | ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK |
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