$Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters: Altered response is accompanied by reduced sensitivity to prostaglandin E sub(2) and altered down-regulation of phorbol ester binding sites$

Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters: Altered response is accompanied by reduced sensitivity to prostaglandin E sub(2) and altered down-regulation of phorbol ester binding sites

To investigate abnormal growth regulation in keloid fibroblasts, response to phorbol esters were examined. Treatment of quiescent cultures with phorbol 12-myristate 13-acetate (PMA) blocked a normally occurring (20-24 h) peak of serum-stimulated thymidine incorporation in normal and keloid cells. Th...

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Veröffentlicht in:	The Journal of biological chemistry 1992-01, Vol.267 (13), p.9014-9020
Hauptverfasser:	Myles, ME, Russell, J D, Trupin, J S, Smith, J C, Russell, S B
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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