Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters: Altered response is accompanied by reduced sensitivity to prostaglandin E sub(2) and altered down-regulation of phorbol ester binding sites
To investigate abnormal growth regulation in keloid fibroblasts, response to phorbol esters were examined. Treatment of quiescent cultures with phorbol 12-myristate 13-acetate (PMA) blocked a normally occurring (20-24 h) peak of serum-stimulated thymidine incorporation in normal and keloid cells. Th...
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| Veröffentlicht in: | The Journal of biological chemistry 1992-01, Vol.267 (13), p.9014-9020 |
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| container_end_page | 9020 |
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| container_issue | 13 |
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| container_title | The Journal of biological chemistry |
| container_volume | 267 |
| creator | Myles, ME Russell, J D Trupin, J S Smith, J C Russell, S B |
| description | To investigate abnormal growth regulation in keloid fibroblasts, response to phorbol esters were examined. Treatment of quiescent cultures with phorbol 12-myristate 13-acetate (PMA) blocked a normally occurring (20-24 h) peak of serum-stimulated thymidine incorporation in normal and keloid cells. The findings suggest that altered expression of protein kinase C isozymes or another molecule that binds phorbol esters may play a role in abnormal growth regulation of keloid cells. |
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| ispartof | The Journal of biological chemistry, 1992-01, Vol.267 (13), p.9014-9020 |
| issn | 0021-9258 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| title | Keloid fibroblasts are refractory to inhibition of DNA synthesis by phorbol esters: Altered response is accompanied by reduced sensitivity to prostaglandin E sub(2) and altered down-regulation of phorbol ester binding sites |
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