Subacute oral toxicity of 2-butyne-1,4-diol in rats
2‐Butyne‐1,4‐diol was given to male and female Wistar Imp:DAK rats by oral gavage for 28 consecutive days in daily doses of 1, 10 or 50 mg kg−1 day−1. After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Tr...
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| Veröffentlicht in: | Journal of applied toxicology 1992-04, Vol.12 (2), p.117-122 |
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| creator | Jedrychowski, Ryszard A. Czajkowska, Teresa Gorny, Roman Stetkiewicz, Jan Stetkiewicz, Irena |
| description | 2‐Butyne‐1,4‐diol was given to male and female Wistar Imp:DAK rats by oral gavage for 28 consecutive days in daily doses of 1, 10 or 50 mg kg−1 day−1. After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Treatment‐related effects in the high‐dose group consisted of: fatal cases in both sexes; depressed body weight gain in males; increase of absolute and/or relative weights of liver and kidneys in both sexes; decreased red blood cell count, haematocrit value and haemoglobin concentration in female rats and elevated reticulocyte count and leukocyte count in both sexes; increased total serum protein content in females, elevated glucose concentration in males and higher activity of sorbitol dehydrogenase in both sexes; and hisiopathological evidence of hepatotoxicky and nephrotnxicity in decedents, and hepatic and splenic changes in survivors. Minor hepatic, splenic and erythrocytic changes were also found in some females given the middle dose. The dose of 1 mg kg−1 day−1 was considered to be the no‐observed‐effect level (NOEL), and 10 mg kg−1 day−1 the lowest‐observed‐eflfect level (LOEL). |
| doi_str_mv | 10.1002/jat.2550120208 |
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After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Treatment‐related effects in the high‐dose group consisted of: fatal cases in both sexes; depressed body weight gain in males; increase of absolute and/or relative weights of liver and kidneys in both sexes; decreased red blood cell count, haematocrit value and haemoglobin concentration in female rats and elevated reticulocyte count and leukocyte count in both sexes; increased total serum protein content in females, elevated glucose concentration in males and higher activity of sorbitol dehydrogenase in both sexes; and hisiopathological evidence of hepatotoxicky and nephrotnxicity in decedents, and hepatic and splenic changes in survivors. Minor hepatic, splenic and erythrocytic changes were also found in some females given the middle dose. The dose of 1 mg kg−1 day−1 was considered to be the no‐observed‐effect level (NOEL), and 10 mg kg−1 day−1 the lowest‐observed‐eflfect level (LOEL).</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550120208</identifier><identifier>PMID: 1556378</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>2-butyne-1 ; 2‐butyne‐1,4‐diol ; 4-diol ; Animals ; Biological and medical sciences ; Butylene Glycols - toxicity ; Chemical and industrial products toxicology. Toxic occupational diseases ; Female ; Kidney - drug effects ; Liver - drug effects ; Lung - drug effects ; Male ; Medical sciences ; oral ; Organ Size - drug effects ; rat ; Rats ; Rats, Inbred Strains ; subacute ; toxicity ; Toxicology ; Various organic compounds</subject><ispartof>Journal of applied toxicology, 1992-04, Vol.12 (2), p.117-122</ispartof><rights>Copyright © 1992 John Wiley & Sons, Ltd.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4248-fa38d5d068b0c1bf0f955737b5ce411ce209efc417b2da11238da9cf2a7a7c993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550120208$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550120208$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5172511$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1556378$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jedrychowski, Ryszard A.</creatorcontrib><creatorcontrib>Czajkowska, Teresa</creatorcontrib><creatorcontrib>Gorny, Roman</creatorcontrib><creatorcontrib>Stetkiewicz, Jan</creatorcontrib><creatorcontrib>Stetkiewicz, Irena</creatorcontrib><title>Subacute oral toxicity of 2-butyne-1,4-diol in rats</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>2‐Butyne‐1,4‐diol was given to male and female Wistar Imp:DAK rats by oral gavage for 28 consecutive days in daily doses of 1, 10 or 50 mg kg−1 day−1. After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Treatment‐related effects in the high‐dose group consisted of: fatal cases in both sexes; depressed body weight gain in males; increase of absolute and/or relative weights of liver and kidneys in both sexes; decreased red blood cell count, haematocrit value and haemoglobin concentration in female rats and elevated reticulocyte count and leukocyte count in both sexes; increased total serum protein content in females, elevated glucose concentration in males and higher activity of sorbitol dehydrogenase in both sexes; and hisiopathological evidence of hepatotoxicky and nephrotnxicity in decedents, and hepatic and splenic changes in survivors. Minor hepatic, splenic and erythrocytic changes were also found in some females given the middle dose. The dose of 1 mg kg−1 day−1 was considered to be the no‐observed‐effect level (NOEL), and 10 mg kg−1 day−1 the lowest‐observed‐eflfect level (LOEL).</description><subject>2-butyne-1</subject><subject>2‐butyne‐1,4‐diol</subject><subject>4-diol</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Butylene Glycols - toxicity</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Female</subject><subject>Kidney - drug effects</subject><subject>Liver - drug effects</subject><subject>Lung - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>oral</subject><subject>Organ Size - drug effects</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>subacute</subject><subject>toxicity</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM9P2zAYhq0JBB1w3W1SDminuXyfY8fxEaHRbeKXVBC7WY5jSy5pA3aitf89QamoOHHy4X3e97MeQr4hTBGAnS1MN2VCADJgUH4hEwSlKLIi3yMTYAVQnst_h-RrSguAIWPlATlAIYpclhOSz_vK2L5zWRtNk3XtOtjQbbLWZ4xWfbdZOYo_Oa1D22RhlUXTpWOy702T3Mn2PSIPl7_uL37Tq9vZn4vzK2o54yX1Ji9rUUNRVmCx8uCVEDKXlbCOI1rHQDlvOcqK1QaRDbhR1jMjjbRK5Ufkx7j7HNuX3qVOL0OyrmnMyrV90lgMC5Lzz0HOFHB4W5yOoI1tStF5_RzD0sSNRtBvOvWgU-90DoXv2-W-Wrp6h4_-hvx0m5tkTeOjWdmQ3jGBkgnEAVMj9j80bvPJUf33_P7DF-jYDalz6_euiU-6GGwK_Xgz0_OivLu-nAuN-SuqzZp0</recordid><startdate>199204</startdate><enddate>199204</enddate><creator>Jedrychowski, Ryszard A.</creator><creator>Czajkowska, Teresa</creator><creator>Gorny, Roman</creator><creator>Stetkiewicz, Jan</creator><creator>Stetkiewicz, Irena</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope></search><sort><creationdate>199204</creationdate><title>Subacute oral toxicity of 2-butyne-1,4-diol in rats</title><author>Jedrychowski, Ryszard A. ; Czajkowska, Teresa ; Gorny, Roman ; Stetkiewicz, Jan ; Stetkiewicz, Irena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4248-fa38d5d068b0c1bf0f955737b5ce411ce209efc417b2da11238da9cf2a7a7c993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>2-butyne-1</topic><topic>2‐butyne‐1,4‐diol</topic><topic>4-diol</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Butylene Glycols - toxicity</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Female</topic><topic>Kidney - drug effects</topic><topic>Liver - drug effects</topic><topic>Lung - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>oral</topic><topic>Organ Size - drug effects</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>subacute</topic><topic>toxicity</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jedrychowski, Ryszard A.</creatorcontrib><creatorcontrib>Czajkowska, Teresa</creatorcontrib><creatorcontrib>Gorny, Roman</creatorcontrib><creatorcontrib>Stetkiewicz, Jan</creatorcontrib><creatorcontrib>Stetkiewicz, Irena</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jedrychowski, Ryszard A.</au><au>Czajkowska, Teresa</au><au>Gorny, Roman</au><au>Stetkiewicz, Jan</au><au>Stetkiewicz, Irena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subacute oral toxicity of 2-butyne-1,4-diol in rats</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1992-04</date><risdate>1992</risdate><volume>12</volume><issue>2</issue><spage>117</spage><epage>122</epage><pages>117-122</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>2‐Butyne‐1,4‐diol was given to male and female Wistar Imp:DAK rats by oral gavage for 28 consecutive days in daily doses of 1, 10 or 50 mg kg−1 day−1. After 28 days all animals were necropsied. Blood samples were obtained and selected organs were weighed and prepared for histological examination. Treatment‐related effects in the high‐dose group consisted of: fatal cases in both sexes; depressed body weight gain in males; increase of absolute and/or relative weights of liver and kidneys in both sexes; decreased red blood cell count, haematocrit value and haemoglobin concentration in female rats and elevated reticulocyte count and leukocyte count in both sexes; increased total serum protein content in females, elevated glucose concentration in males and higher activity of sorbitol dehydrogenase in both sexes; and hisiopathological evidence of hepatotoxicky and nephrotnxicity in decedents, and hepatic and splenic changes in survivors. Minor hepatic, splenic and erythrocytic changes were also found in some females given the middle dose. The dose of 1 mg kg−1 day−1 was considered to be the no‐observed‐effect level (NOEL), and 10 mg kg−1 day−1 the lowest‐observed‐eflfect level (LOEL).</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1556378</pmid><doi>10.1002/jat.2550120208</doi><tpages>6</tpages></addata></record> |
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| subjects | 2-butyne-1 2‐butyne‐1,4‐diol 4-diol Animals Biological and medical sciences Butylene Glycols - toxicity Chemical and industrial products toxicology. Toxic occupational diseases Female Kidney - drug effects Liver - drug effects Lung - drug effects Male Medical sciences oral Organ Size - drug effects rat Rats Rats, Inbred Strains subacute toxicity Toxicology Various organic compounds |
| title | Subacute oral toxicity of 2-butyne-1,4-diol in rats |
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