Cholinergic activity and amyloid precursor protein metabolism

With more than 4 million Alzheimer's victims nationwide, there is intense research to elucidate the relationship among the hallmarks of the disease, amyloid plaques, neurofibrillary tangles, and degeneration of the basal forebrain cholinergic neurons. There has been much debate about which of t...

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Veröffentlicht in:	Brain Research Reviews 1997-09, Vol.25 (1), p.50-69
Hauptverfasser:	Roberson, Melinda R, Harrell, Lindy E
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - metabolism Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Protein Precursor - biosynthesis Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Animals Basal forebrain Brain - pathology Brain - physiology Brain - physiopathology Cholinergic Hippocampus Hippocampus - pathology Hippocampus - physiology Hippocampus - physiopathology Humans Learning Memory Models, Neurological Muscarinic receptor Nucleus basalis of Meynert Protein Processing, Post-Translational Receptors, Muscarinic - physiology β-amyloid
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