Expression of epidermal growth factor receptor in plutonium-239-induced lung neoplasms in dogs

The expression of epidermal growth factor receptor (EGF-R) was examined in canine lung tumors and in proliferative epithelial foci induced by plutonium-239 to determine if EGF-R was associated with specific neoplastic phenotypes or putative preneoplastic lesions. Seventeen (47%) of 36 canine lung tu...

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Veröffentlicht in:	Veterinary pathology 1992-01, Vol.29 (1), p.46-52
Hauptverfasser:	Gillett, N.A. (Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM), Stegelmeier, B.L, Kelly, G, Haley, P.J, Hahn, F.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemistry Adenocarcinoma - genetics Adenocarcinoma - veterinary Adenocarcinoma, Bronchiolo-Alveolar - chemistry Adenocarcinoma, Bronchiolo-Alveolar - genetics Adenocarcinoma, Bronchiolo-Alveolar - veterinary Adenocarcinoma, Papillary - chemistry Adenocarcinoma, Papillary - genetics Adenocarcinoma, Papillary - veterinary AETIOLOGY ALPHA RADIATION Animals Blotting, Western CARCINOGENOS CARCINOGENS Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - veterinary CHIEN Disease Models, Animal Dog Diseases - genetics Dog Diseases - pathology DOGS ETIOLOGIA ETIOLOGIE ETIOLOGY FENOTIPOS GENE Gene Expression Regulation, Neoplastic GENES GROWTH PROMOTORS Immunohistochemistry LESION LESIONES LESIONS Lung Neoplasms - chemistry Lung Neoplasms - genetics Lung Neoplasms - veterinary LUNGS NEOPLASMAS NEOPLASME NEOPLASMS Nucleic Acid Hybridization ONCOGENES PERRO PHENOTYPE PHENOTYPES PLUTONIO PLUTONIUM POUMON PROMOTEUR DE CROISSANCE PROMOTORES DEL CRECIMIENTO Proto-Oncogenes PULMONES RADIACIONES RADIATION RADIATIONS Receptor, Epidermal Growth Factor - analysis RNA Probes RNA, Messenger - analysis RNA, Neoplasm - analysis Sarcoma, Experimental - chemistry Sarcoma, Experimental - genetics SUBSTANCE CANCERIGENE
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