MR imaging in hepatocellular carcinoma: correlations between MRI features and molecular marker VEGF
The aim of this paper was to investigate the correlations between magnetic resonance imaging (MRI) features and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). Thirty-six patients with HCC included in this study underwent dynamic contrast-enhanced MR imaging and diffusio...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2014-12, Vol.31 (12), p.313-313, Article 313 |
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| creator | Huang, Zhaoqin Meng, Xiangjiao Xiu, Jianjun Xu, Xiuqin Bi, Lei Zhang, Jie Han, Xue Liu, Qingwei |
| description | The aim of this paper was to investigate the correlations between magnetic resonance imaging (MRI) features and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). Thirty-six patients with HCC included in this study underwent dynamic contrast-enhanced MR imaging and diffusion-weighted MR imaging. Signal intensity characteristics of HCCs were reviewed independently by two experienced radiologists. ADC maps were automatically computed. VEGF expression was evaluated by immunohistochemical staining. The grades of the VEGF expression were correlated inversely with the ADC values of the HCCs (
r
= −0.435,
p
= 0.008). Intensity heterogeneity correlated with VEGF expression (
r
= 0.571,
p
= 0.039). There is a significant correlation between the intensity of arterial enhancement and VEGF expression (
r
= −0.386,
p
= 0.02). However, no correlation was found between the VEGF grades and the intensity of enhancement in the hepatic portal venous and late phases, as well as equilibrium phase. Our results indicate that ADC value on DW-MRI, the signal intensity in arterial phase and intensity heterogeneity correlate with the degree of VEGF expression in hepatocellular carcinomas. |
| doi_str_mv | 10.1007/s12032-014-0313-0 |
| format | Article |
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r
= −0.435,
p
= 0.008). Intensity heterogeneity correlated with VEGF expression (
r
= 0.571,
p
= 0.039). There is a significant correlation between the intensity of arterial enhancement and VEGF expression (
r
= −0.386,
p
= 0.02). However, no correlation was found between the VEGF grades and the intensity of enhancement in the hepatic portal venous and late phases, as well as equilibrium phase. Our results indicate that ADC value on DW-MRI, the signal intensity in arterial phase and intensity heterogeneity correlate with the degree of VEGF expression in hepatocellular carcinomas.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-014-0313-0</identifier><identifier>PMID: 25367856</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Biomarkers, Tumor - metabolism ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Contrast Media ; Hematology ; Humans ; Image Interpretation, Computer-Assisted ; Internal Medicine ; Liver - blood supply ; Liver - pathology ; Liver Neoplasms - diagnosis ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine & Public Health ; Middle Aged ; Neovascularization, Pathologic - metabolism ; Neovascularization, Pathologic - pathology ; Oncology ; Original Paper ; Pathology ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Medical oncology (Northwood, London, England), 2014-12, Vol.31 (12), p.313-313, Article 313</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-81575033de8f87588a8c0aded34d9e606582eebad268eb4214a9b853a3ca753b3</citedby><cites>FETCH-LOGICAL-c442t-81575033de8f87588a8c0aded34d9e606582eebad268eb4214a9b853a3ca753b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-014-0313-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-014-0313-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25367856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Zhaoqin</creatorcontrib><creatorcontrib>Meng, Xiangjiao</creatorcontrib><creatorcontrib>Xiu, Jianjun</creatorcontrib><creatorcontrib>Xu, Xiuqin</creatorcontrib><creatorcontrib>Bi, Lei</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Han, Xue</creatorcontrib><creatorcontrib>Liu, Qingwei</creatorcontrib><title>MR imaging in hepatocellular carcinoma: correlations between MRI features and molecular marker VEGF</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>The aim of this paper was to investigate the correlations between magnetic resonance imaging (MRI) features and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). Thirty-six patients with HCC included in this study underwent dynamic contrast-enhanced MR imaging and diffusion-weighted MR imaging. Signal intensity characteristics of HCCs were reviewed independently by two experienced radiologists. ADC maps were automatically computed. VEGF expression was evaluated by immunohistochemical staining. The grades of the VEGF expression were correlated inversely with the ADC values of the HCCs (
r
= −0.435,
p
= 0.008). Intensity heterogeneity correlated with VEGF expression (
r
= 0.571,
p
= 0.039). There is a significant correlation between the intensity of arterial enhancement and VEGF expression (
r
= −0.386,
p
= 0.02). However, no correlation was found between the VEGF grades and the intensity of enhancement in the hepatic portal venous and late phases, as well as equilibrium phase. Our results indicate that ADC value on DW-MRI, the signal intensity in arterial phase and intensity heterogeneity correlate with the degree of VEGF expression in hepatocellular carcinomas.</description><subject>Adult</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Contrast Media</subject><subject>Hematology</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Internal Medicine</subject><subject>Liver - blood supply</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neovascularization, Pathologic - metabolism</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtLLDEQhYNc8TH6A9xcAnfjpjWPTjrtTgZfoAii4q6pTtfMbe1OxqQb8d-bcVREcJME6qtTJ3UI2ePsgDNWHEYumBQZ43nGJJcZWyNbXKky45I__ElvqYqMKc02yXaMj4wJrkS5QTaFkrowSm8Re3VD2x7mrZvT1tH_uIDBW-y6sYNALQTbOt_DEbU-BOxgaL2LtMbhBdHRq5sLOkMYxoCRgmto7zu07609hCcM9P7k7HSHrM-gi7j7cU_I3enJ7fQ8u7w-u5geX2Y2z8WQGa4KxaRs0MxMoYwBYxk02Mi8KVEzrYxArKER2mCdC55DWRslQVoolKzlhOyvdBfBP48Yh6pv4_Iv4NCPseJasCSrpUjovx_oox-DS-4SxcvkR0qdKL6ibPAxBpxVi5CWFV4rzqplAtUqgSolUC0TSMeE_P1QHusem6-Oz5UnQKyAmEpujuHb6F9V3wBiTJAM</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Huang, Zhaoqin</creator><creator>Meng, Xiangjiao</creator><creator>Xiu, Jianjun</creator><creator>Xu, Xiuqin</creator><creator>Bi, Lei</creator><creator>Zhang, Jie</creator><creator>Han, Xue</creator><creator>Liu, Qingwei</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20141201</creationdate><title>MR imaging in hepatocellular carcinoma: correlations between MRI features and molecular marker VEGF</title><author>Huang, Zhaoqin ; Meng, Xiangjiao ; Xiu, Jianjun ; Xu, Xiuqin ; Bi, Lei ; Zhang, Jie ; Han, Xue ; Liu, Qingwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-81575033de8f87588a8c0aded34d9e606582eebad268eb4214a9b853a3ca753b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - metabolism</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Contrast Media</topic><topic>Hematology</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Internal Medicine</topic><topic>Liver - blood supply</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neovascularization, Pathologic - metabolism</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Zhaoqin</creatorcontrib><creatorcontrib>Meng, Xiangjiao</creatorcontrib><creatorcontrib>Xiu, Jianjun</creatorcontrib><creatorcontrib>Xu, Xiuqin</creatorcontrib><creatorcontrib>Bi, Lei</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Han, Xue</creatorcontrib><creatorcontrib>Liu, Qingwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Zhaoqin</au><au>Meng, Xiangjiao</au><au>Xiu, Jianjun</au><au>Xu, Xiuqin</au><au>Bi, Lei</au><au>Zhang, Jie</au><au>Han, Xue</au><au>Liu, Qingwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MR imaging in hepatocellular carcinoma: correlations between MRI features and molecular marker VEGF</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>31</volume><issue>12</issue><spage>313</spage><epage>313</epage><pages>313-313</pages><artnum>313</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>The aim of this paper was to investigate the correlations between magnetic resonance imaging (MRI) features and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC). Thirty-six patients with HCC included in this study underwent dynamic contrast-enhanced MR imaging and diffusion-weighted MR imaging. Signal intensity characteristics of HCCs were reviewed independently by two experienced radiologists. ADC maps were automatically computed. VEGF expression was evaluated by immunohistochemical staining. The grades of the VEGF expression were correlated inversely with the ADC values of the HCCs (
r
= −0.435,
p
= 0.008). Intensity heterogeneity correlated with VEGF expression (
r
= 0.571,
p
= 0.039). There is a significant correlation between the intensity of arterial enhancement and VEGF expression (
r
= −0.386,
p
= 0.02). However, no correlation was found between the VEGF grades and the intensity of enhancement in the hepatic portal venous and late phases, as well as equilibrium phase. Our results indicate that ADC value on DW-MRI, the signal intensity in arterial phase and intensity heterogeneity correlate with the degree of VEGF expression in hepatocellular carcinomas.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>25367856</pmid><doi>10.1007/s12032-014-0313-0</doi><tpages>1</tpages></addata></record> |
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| ispartof | Medical oncology (Northwood, London, England), 2014-12, Vol.31 (12), p.313-313, Article 313 |
| issn | 1357-0560 1559-131X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Contrast Media Hematology Humans Image Interpretation, Computer-Assisted Internal Medicine Liver - blood supply Liver - pathology Liver Neoplasms - diagnosis Liver Neoplasms - metabolism Liver Neoplasms - pathology Magnetic Resonance Imaging - methods Medicine Medicine & Public Health Middle Aged Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Oncology Original Paper Pathology Vascular Endothelial Growth Factor A - metabolism |
| title | MR imaging in hepatocellular carcinoma: correlations between MRI features and molecular marker VEGF |
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