Role of CD11b/CD18 in priming of human leukocytes by endotoxin glycoforms from Escherichia coli
The primary objective of this study was to determine the role of β2 integrin α-subunit (CD11b) in the mechanism of human polymorphonuclear leukocyte (PML) priming by S or Re endotoxin glycoforms from Escherichia coli for fMLP-induced respiratory burst. Similar priming activity of S and Re endotoxin...
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| Veröffentlicht in: | Biochemistry (Moscow) 2014-08, Vol.79 (8), p.812-819 |
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| creator | Kabanov, D. S. Grachev, S. V. Prokhorenko, I. R. |
| description | The primary objective of this study was to determine the role of β2 integrin α-subunit (CD11b) in the mechanism of human polymorphonuclear leukocyte (PML) priming by S or Re endotoxin glycoforms from
Escherichia coli
for fMLP-induced respiratory burst. Similar priming activity of S and Re endotoxin glycoforms for fMLP-induced reactive oxygen species (ROS) generation from primed PML was found. Anti-CD11b antibodies (clone ICRF 44) as well as isotypematched immunoglobulin G1 (clone MOPC-21) do not influence the fMLP-induced ROS generation from unprimed PML. Antibodies against CD11b do not change fMLP-induced ROS generation from endotoxin-primed PML as well. The involvement of different isoforms of Fcγ receptors in fMLP-induced ROS generation from activated PML is proposed. |
| doi_str_mv | 10.1134/S0006297914080094 |
| format | Article |
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Escherichia coli
for fMLP-induced respiratory burst. Similar priming activity of S and Re endotoxin glycoforms for fMLP-induced reactive oxygen species (ROS) generation from primed PML was found. Anti-CD11b antibodies (clone ICRF 44) as well as isotypematched immunoglobulin G1 (clone MOPC-21) do not influence the fMLP-induced ROS generation from unprimed PML. Antibodies against CD11b do not change fMLP-induced ROS generation from endotoxin-primed PML as well. The involvement of different isoforms of Fcγ receptors in fMLP-induced ROS generation from activated PML is proposed.</description><identifier>ISSN: 0006-2979</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297914080094</identifier><identifier>PMID: 25365491</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Antibodies, Monoclonal - immunology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; CD11b Antigen - immunology ; CD18 Antigens - immunology ; Cell interaction ; Cell research ; E coli ; Endotoxins ; Endotoxins - chemistry ; Endotoxins - immunology ; Escherichia coli ; Escherichia coli - chemistry ; Escherichia coli - immunology ; Glycosylation ; Health aspects ; Humans ; Immunoglobulins ; Leukocytes ; Leukocytes - cytology ; Leukocytes - immunology ; Life Sciences ; Lipopolysaccharides - immunology ; Microbiological research ; Microbiology ; Reactive Oxygen Species - metabolism ; Respiratory Burst - immunology ; Signal transduction ; T cells ; Toxins</subject><ispartof>Biochemistry (Moscow), 2014-08, Vol.79 (8), p.812-819</ispartof><rights>Pleiades Publishing, Ltd. 2014</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-701bb821fa9a12295e411b8788db0c1435fa6fbcf4180508b0d2c773ccde5a443</citedby><cites>FETCH-LOGICAL-c472t-701bb821fa9a12295e411b8788db0c1435fa6fbcf4180508b0d2c773ccde5a443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297914080094$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297914080094$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25365491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kabanov, D. S.</creatorcontrib><creatorcontrib>Grachev, S. V.</creatorcontrib><creatorcontrib>Prokhorenko, I. R.</creatorcontrib><title>Role of CD11b/CD18 in priming of human leukocytes by endotoxin glycoforms from Escherichia coli</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>The primary objective of this study was to determine the role of β2 integrin α-subunit (CD11b) in the mechanism of human polymorphonuclear leukocyte (PML) priming by S or Re endotoxin glycoforms from
Escherichia coli
for fMLP-induced respiratory burst. Similar priming activity of S and Re endotoxin glycoforms for fMLP-induced reactive oxygen species (ROS) generation from primed PML was found. Anti-CD11b antibodies (clone ICRF 44) as well as isotypematched immunoglobulin G1 (clone MOPC-21) do not influence the fMLP-induced ROS generation from unprimed PML. Antibodies against CD11b do not change fMLP-induced ROS generation from endotoxin-primed PML as well. The involvement of different isoforms of Fcγ receptors in fMLP-induced ROS generation from activated PML is proposed.</description><subject>Antibodies, Monoclonal - immunology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>CD11b Antigen - immunology</subject><subject>CD18 Antigens - immunology</subject><subject>Cell interaction</subject><subject>Cell research</subject><subject>E coli</subject><subject>Endotoxins</subject><subject>Endotoxins - chemistry</subject><subject>Endotoxins - immunology</subject><subject>Escherichia coli</subject><subject>Escherichia coli - chemistry</subject><subject>Escherichia coli - immunology</subject><subject>Glycosylation</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Leukocytes</subject><subject>Leukocytes - cytology</subject><subject>Leukocytes - immunology</subject><subject>Life Sciences</subject><subject>Lipopolysaccharides - immunology</subject><subject>Microbiological research</subject><subject>Microbiology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Respiratory Burst - immunology</subject><subject>Signal transduction</subject><subject>T cells</subject><subject>Toxins</subject><issn>0006-2979</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUuLFDEUhYMoTjv6A9xIwI2bmrl5VrIcesYHDAg-1iGVSrozVlXGpArsf2-KHt-KBBKS853LvTkIPSVwRgjj5-8BQFLdasJBAWh-D22IBNUw4HAfbVa5WfUT9KiUm3qloNlDdEIFk4JrskHmXRo8TgFvLwnpzuuucJzwbY5jnHarsF9GO-HBL5-SO8y-4O6A_dSnOX2p4G44uBRSHgsOOY34qri9z9Hto8UuDfExehDsUPyTu_MUfXx59WH7url---rN9uK6cbylc9MC6TpFSbDaEkq18Ly2o1ql-g4c4UwEK0PnAicKBKgOeuraljnXe2E5Z6foxbHubU6fF19mM8bi_DDYyaelGCIpCCUltP9HhQQCSlBS0ee_oTdpyVMdpFKC1o_Xmv2gdnbwJk4hzdm6tai5YIppBYrLSp39haqr92N0afIh1vdfDORocDmVkn0wayo2HwwBs-Zv_si_ep7dNbx0o--_O74FXgF6BEqVpp3PP030z6pfAXFotWo</recordid><startdate>20140801</startdate><enddate>20140801</enddate><creator>Kabanov, D. 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S. ; Grachev, S. V. ; Prokhorenko, I. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-701bb821fa9a12295e411b8788db0c1435fa6fbcf4180508b0d2c773ccde5a443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Antibodies, Monoclonal - immunology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>CD11b Antigen - immunology</topic><topic>CD18 Antigens - immunology</topic><topic>Cell interaction</topic><topic>Cell research</topic><topic>E coli</topic><topic>Endotoxins</topic><topic>Endotoxins - chemistry</topic><topic>Endotoxins - immunology</topic><topic>Escherichia coli</topic><topic>Escherichia coli - chemistry</topic><topic>Escherichia coli - immunology</topic><topic>Glycosylation</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Leukocytes</topic><topic>Leukocytes - cytology</topic><topic>Leukocytes - immunology</topic><topic>Life Sciences</topic><topic>Lipopolysaccharides - immunology</topic><topic>Microbiological research</topic><topic>Microbiology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Respiratory Burst - immunology</topic><topic>Signal transduction</topic><topic>T cells</topic><topic>Toxins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kabanov, D. S.</creatorcontrib><creatorcontrib>Grachev, S. V.</creatorcontrib><creatorcontrib>Prokhorenko, I. 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S.</au><au>Grachev, S. V.</au><au>Prokhorenko, I. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of CD11b/CD18 in priming of human leukocytes by endotoxin glycoforms from Escherichia coli</atitle><jtitle>Biochemistry (Moscow)</jtitle><stitle>Biochemistry Moscow</stitle><addtitle>Biochemistry (Mosc)</addtitle><date>2014-08-01</date><risdate>2014</risdate><volume>79</volume><issue>8</issue><spage>812</spage><epage>819</epage><pages>812-819</pages><issn>0006-2979</issn><eissn>1608-3040</eissn><abstract>The primary objective of this study was to determine the role of β2 integrin α-subunit (CD11b) in the mechanism of human polymorphonuclear leukocyte (PML) priming by S or Re endotoxin glycoforms from
Escherichia coli
for fMLP-induced respiratory burst. Similar priming activity of S and Re endotoxin glycoforms for fMLP-induced reactive oxygen species (ROS) generation from primed PML was found. Anti-CD11b antibodies (clone ICRF 44) as well as isotypematched immunoglobulin G1 (clone MOPC-21) do not influence the fMLP-induced ROS generation from unprimed PML. Antibodies against CD11b do not change fMLP-induced ROS generation from endotoxin-primed PML as well. The involvement of different isoforms of Fcγ receptors in fMLP-induced ROS generation from activated PML is proposed.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>25365491</pmid><doi>10.1134/S0006297914080094</doi><tpages>8</tpages></addata></record> |
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| subjects | Antibodies, Monoclonal - immunology Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry CD11b Antigen - immunology CD18 Antigens - immunology Cell interaction Cell research E coli Endotoxins Endotoxins - chemistry Endotoxins - immunology Escherichia coli Escherichia coli - chemistry Escherichia coli - immunology Glycosylation Health aspects Humans Immunoglobulins Leukocytes Leukocytes - cytology Leukocytes - immunology Life Sciences Lipopolysaccharides - immunology Microbiological research Microbiology Reactive Oxygen Species - metabolism Respiratory Burst - immunology Signal transduction T cells Toxins |
| title | Role of CD11b/CD18 in priming of human leukocytes by endotoxin glycoforms from Escherichia coli |
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