DNA cleavage by oxymyoglobin and cysteine-introduced metmyoglobin

DNA cleavage by oxymyoglobin and cysteine-introduced metmyoglobin

Double stranded DNA was cleaved oxidatively by incubation with oxygenated myoglobin, and Lys96Cys sperm whale myoglobin in its stable ferric form functioned as an artificial nuclease under air by formation of an oxygenated species, owing to electron transfer from the SH group of the introduced cyste...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (95), p.15034-15036
Hauptverfasser: Deshpande, Megha Subhash, Junedi, Sendy, Prakash, Halan, Nagao, Satoshi, Yamanaka, Masaru, Hirota, Shun
Format: Artikel
Sprache:eng
Schlagworte:
Cysteine - chemistry
DNA - chemistry
DNA Cleavage
Metmyoglobin - chemistry
Myoglobin - chemistry
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Zusammenfassung:Double stranded DNA was cleaved oxidatively by incubation with oxygenated myoglobin, and Lys96Cys sperm whale myoglobin in its stable ferric form functioned as an artificial nuclease under air by formation of an oxygenated species, owing to electron transfer from the SH group of the introduced cysteine to the heme.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06617k