Genomic aspects of age-related macular degeneration

•AMD is a late-onset eye disease that impairs central vision among elderly populations.•Lipofuscin accumulation and drusen formation play a role in the pathogenesis of AMD.•Inflammatory and angiogenic pathways are implicated in the pathophysiology of AMD.•ARMS2/HTRA1 and CFH are major AMD susceptibi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-09, Vol.452 (2), p.263-275
Hauptverfasser:	Horie-Inoue, Kuniko, Inoue, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Age-related macular degeneration (AMD) Age-related maculopathy susceptibility protein 2 (ARMS2) Aged Animals Complement factor H (CFH) Disease Models, Animal Genetic Predisposition to Disease Genome-Wide Association Study Genome-wide association study (GWAS) Genomics High-Temperature Requirement A Serine Peptidase 1 HTRA1 Humans Macular Degeneration - genetics Polymorphism, Single Nucleotide Proteins - genetics Serine Endopeptidases - genetics Single nucleotide polymorphism (SNP)
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