Role of genomics in translational research for Parkinson’s disease

•Genomic technologies have uncovered the mechanism of Parkinson’s disease (PD).•Dozens of familial risk factors, including α-synuclein, have been identified.•Genome wide association studies of sporadic PD have been extensively performed.•MicroRNAs might be promising as biomarkers and therapeutic rea...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-09, Vol.452 (2), p.226-235
Hauptverfasser:	Sekiyama, Kazunari, Takamatsu, Yoshiki, Waragai, Masaaki, Hashimoto, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid - antagonists & inhibitors Apoptosis Early Diagnosis Genome wide association studies (GWAS) Genome-Wide Association Study Genomics High-Throughput Nucleotide Sequencing Humans microRNA (miRNA) Neurons - pathology Oligonucleotide Array Sequence Analysis Parkinson Disease - diagnosis Parkinson Disease - genetics Parkinson Disease - therapy Parkinson’s disease (PD) Synuclein Synucleins - chemistry Synucleins - genetics Synucleins - metabolism Translational Medical Research
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