Ceramide stimulates a cytosolic protein phosphatase

A sphingomyelin cycle has been identified whereby the action of certain extracellular agents results in reversible sphingomyelin hydrolysis and the concomitant generation of ceramide. Moreover, a cell-permeable ceramide, C2-ceramide (N-acetylsphingosine), is a potent modulator of cell proliferation...

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Veröffentlicht in:	The Journal of biological chemistry 1992-03, Vol.267 (8), p.5048-5051
Hauptverfasser:	DOBROWSKY, R. T, HANNUN, Y. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Cell Line ceramide Ceramides - pharmacology Chromatography, Ion Exchange Cytosol - enzymology Enzymes and enzyme inhibitors Ethers, Cyclic - pharmacology Fundamental and applied biological sciences. Psychology Humans Hydrolases Kinetics Okadaic Acid Phosphoprotein Phosphatases - antagonists & inhibitors Phosphoprotein Phosphatases - isolation & purification Phosphoprotein Phosphatases - metabolism Phosphorylation protein-tyrosine phosphatase Sphingomyelins - pharmacology Sphingosine - pharmacology stimulation T9 cells
Online-Zugang:	Volltext
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