Stimulation of GRP78 gene transcription by phorbol ester and cAMP in GH sub(3) pituitary cells: The accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium

GRP78/BiP resides in the lumen of the endoplasmic reticulum (ER), a major site of Ca super(2+) sequestration and early protein processing. Agents, such as ionophore A23187, that mobilize sequestered ER Ca super(2+) suppress translational initiation within minutes and induce GRP78 within 1-3 h accomp...

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Veröffentlicht in:	The Journal of biological chemistry 1991-01, Vol.266 (29), p.19790-19795
Hauptverfasser:	Prostko, C R, Brostrom, MA, Galuska-Malara, E M, Brostrom, C O
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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