Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer

Regional lymph node metastasis negatively affects prognosis in colon cancer patients. The molecular processes leading to regional lymph node metastasis are only partially understood and proteomic markers for metastasis are still scarce. Therefore, a tissue‐based proteomic approach was undertaken for...

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Veröffentlicht in:	The Journal of pathology 2012-12, Vol.228 (4), p.459-470
Hauptverfasser:	Meding, Stephan, Balluff, Benjamin, Elsner, Mareike, Schöne, Cédrik, Rauser, Sandra, Nitsche, Ulrich, Maak, Matthias, Schäfer, Alexander, Hauck, Stefanie M, Ueffing, Marius, Langer, Rupert, Höfler, Heinz, Friess, Helmut, Rosenberg, Robert, Walch, Axel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Cervical cancer colorectal cancer Colorectal Neoplasms - metabolism Colorectal Neoplasms - secondary Female Gastroenterology. Liver. Pancreas. Abdomen Glutathione Transferase - metabolism Hematologic and hematopoietic diseases Humans immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) label-free quantitative proteomics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis Lymphatic system MALDI imaging Male Medical sciences Membrane Proteins - metabolism Metastasis Middle Aged Neoplasm Proteins - metabolism Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Proteins Proteomics regional lymph node metastasis S100 Proteins - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Stomach. Duodenum. Small intestine. Colon. Rectum. Anus tissue proteomics Tumors
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