PhRMA CPCDC Initiative on Predictive Models of Human Pharmacokinetics, Part 1: Goals, Properties of the Phrma Dataset, and Comparison with Literature Datasets

This study is part of the Pharmaceutical Research and Manufacturers of America (PhRMA) initiative on predictive models of efficacy, safety, and compound properties. The overall goal of this part was to assess the predictability of human pharmacokinetics (PK) from preclinical data and to provide comp...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2011-10, Vol.100 (10), p.4050-4073
Hauptverfasser:	Poulin, Patrick, Jones, Hannah M., Jones, Rhys Do, Yates, James W.T., Gibson, Christopher R., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Sherry Ku, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Access to Information Administration, Intravenous Administration, Oral allometry Animals bioavailability Biological and medical sciences clearance computational ADME Computer Simulation Cooperative Behavior Databases, Pharmaceutical Drug Discovery - methods Drug Evaluation, Preclinical first-in-human General pharmacology Humans Interdisciplinary Communication Medical sciences Models, Biological Models, Statistical oral absorption PBPK Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - blood Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism Pharmaceutical technology. Pharmaceutical industry Pharmacokinetics Pharmacology. Drug treatments PhRMA Program Development Program Evaluation Reproducibility of Results Risk Assessment Risk Factors Species Specificity volume of distribution
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