Rank-based estimate of four-parameter logistic model

During drug development, the calculation of inhibitory concentration that results in a response of 50% (IC50) is performed thousands of times every day. The nonlinear model most often used to perform this calculation is a four‐parameter logistic, suitably parameterized to estimate the IC50 directly....

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Veröffentlicht in:	Pharmaceutical statistics : the journal of the pharmaceutical industry 2012-05, Vol.11 (3), p.214-221
Hauptverfasser:	Crimin, Kimberly S., McKean, Joseph W., Vidmar, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Assay - methods Inhibitory Concentration 50 Logistic Models
Online-Zugang:	Volltext
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