Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene
7,12-Dimethylbenz(a)anthracene (DMBA) is a polycyclic aromatic hydrocarbon and a component of cigarette smoke that has been identified as a murine reproductive toxicant. The morphometric parameters of total ovarian volume, individual corpus luteum volumes, and total corpora lutea volume were measure...
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| Veröffentlicht in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 1992, Vol.6 (2), p.137-141 |
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| container_title | Reproductive toxicology (Elmsford, N.Y.) |
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| creator | Weitzman, Glenn A. Miller, Michael M. London, Steve N. Mattison, Donald R. |
| description | 7,12-Dimethylbenz(a)anthracene (DMBA) is a polycyclic aromatic hydrocarbon and a component of cigarette smoke that has been identified as a murine reproductive toxicant. The morphometric parameters of total ovarian volume, individual corpus luteum volumes, and total corpora lutea volume were measured in C57BL/6N mice treated with DMBA. Each group received single intraperitoneal injections of 0, 0.1, 1.0, or 10 mg/kg and were sacrificed at 1, 2, 3, or 4 weeks after treatment. DMBA produced a dose-dependent decrease in ovarian volume and number of corpora lutea in each ovary. The observed reduction in total corpora lutea volume did not fully account for the loss in total ovarian volume. This is consistent with previous descriptions of a toxic effect on all ovarian components including growing and resting follicles. Growing follicles that escaped the toxic effects of DMBA and achieved ovulation resulted in a corpus luteum that appeared histologically normal. Morphometric analysis of this animal model further defines the dynamic changes in the mouse ovary in response to DMBA. |
| doi_str_mv | 10.1016/0890-6238(92)90115-A |
| format | Article |
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The morphometric parameters of total ovarian volume, individual corpus luteum volumes, and total corpora lutea volume were measured in C57BL/6N mice treated with DMBA. Each group received single intraperitoneal injections of 0, 0.1, 1.0, or 10 mg/kg and were sacrificed at 1, 2, 3, or 4 weeks after treatment. DMBA produced a dose-dependent decrease in ovarian volume and number of corpora lutea in each ovary. The observed reduction in total corpora lutea volume did not fully account for the loss in total ovarian volume. This is consistent with previous descriptions of a toxic effect on all ovarian components including growing and resting follicles. Growing follicles that escaped the toxic effects of DMBA and achieved ovulation resulted in a corpus luteum that appeared histologically normal. Morphometric analysis of this animal model further defines the dynamic changes in the mouse ovary in response to DMBA.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/0890-6238(92)90115-A</identifier><identifier>PMID: 1591471</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity ; Animals ; Biological and medical sciences ; corpus luteum ; Corpus Luteum - pathology ; dimethylbenz(a)anthracene ; Female ; Medical sciences ; Mice ; Mice, Inbred C57BL ; morphometrics ; mouse ; Organ Size - drug effects ; Ovarian Diseases - chemically induced ; Ovarian Diseases - pathology ; ovary ; Ovary - drug effects ; Ovary - pathology ; polycyclic aromatic hydrocarbon ; reproductive toxicant ; smoking ; Tobacco, tobacco smoking ; toxicant ; Toxicology</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 1992, Vol.6 (2), p.137-141</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-a0467f4040e9b272826b20dc2c7c3d40858644deaa81f993ab79365b4cabb1bf3</citedby><cites>FETCH-LOGICAL-c417t-a0467f4040e9b272826b20dc2c7c3d40858644deaa81f993ab79365b4cabb1bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0890-6238(92)90115-A$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3550,4024,4050,4051,23930,23931,25140,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5222163$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1591471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weitzman, Glenn A.</creatorcontrib><creatorcontrib>Miller, Michael M.</creatorcontrib><creatorcontrib>London, Steve N.</creatorcontrib><creatorcontrib>Mattison, Donald R.</creatorcontrib><title>Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>7,12-Dimethylbenz(a)anthracene (DMBA) is a polycyclic aromatic hydrocarbon and a component of cigarette smoke that has been identified as a murine reproductive toxicant. The morphometric parameters of total ovarian volume, individual corpus luteum volumes, and total corpora lutea volume were measured in C57BL/6N mice treated with DMBA. Each group received single intraperitoneal injections of 0, 0.1, 1.0, or 10 mg/kg and were sacrificed at 1, 2, 3, or 4 weeks after treatment. DMBA produced a dose-dependent decrease in ovarian volume and number of corpora lutea in each ovary. The observed reduction in total corpora lutea volume did not fully account for the loss in total ovarian volume. This is consistent with previous descriptions of a toxic effect on all ovarian components including growing and resting follicles. Growing follicles that escaped the toxic effects of DMBA and achieved ovulation resulted in a corpus luteum that appeared histologically normal. Morphometric analysis of this animal model further defines the dynamic changes in the mouse ovary in response to DMBA.</description><subject>9,10-Dimethyl-1,2-benzanthracene - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>corpus luteum</subject><subject>Corpus Luteum - pathology</subject><subject>dimethylbenz(a)anthracene</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>morphometrics</subject><subject>mouse</subject><subject>Organ Size - drug effects</subject><subject>Ovarian Diseases - chemically induced</subject><subject>Ovarian Diseases - pathology</subject><subject>ovary</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>polycyclic aromatic hydrocarbon</subject><subject>reproductive toxicant</subject><subject>smoking</subject><subject>Tobacco, tobacco smoking</subject><subject>toxicant</subject><subject>Toxicology</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEURYMoY8_oP1CohcgMWJqXSlUqm4FmGD9gxI2Cu_CSekVHqpI2SQ-2v95quxl3rt7innt5HMZeAH8LHLp3vNe87kTTX2pxpTlAW68fsRX0qqlB8f4xWz0gT9l5zj8451JpdcbOoNUgFazY988xbTdxppK8qzBnynmmUKo4VmVD1bxLPlAV7zF5DFWJv7zzZX-I1RsQ9eCX6mY_WQq_L_EKQ9kkdBToGXsy4pTp-elesG_vb7_efKzvvnz4dLO-q50EVWrkslOj5JKTtkKJXnRW8MEJp1wzSN63fSflQIg9jFo3aJVuutZKh9aCHZsL9vq4u03x545yMbPPjqYJA8VdNtCBbpuWL6A8gi7FnBONZpv8jGlvgJuDUHOwZQ62jBbmr1CzXmovT_s7O9Pwr3Q0uOSvTjlmh9OYMDifH7BWCAFds2DXR4wWF_eeksnOU3A0-ESumCH6___xB6CfkbU</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Weitzman, Glenn A.</creator><creator>Miller, Michael M.</creator><creator>London, Steve N.</creator><creator>Mattison, Donald R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1992</creationdate><title>Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene</title><author>Weitzman, Glenn A. ; Miller, Michael M. ; London, Steve N. ; Mattison, Donald R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-a0467f4040e9b272826b20dc2c7c3d40858644deaa81f993ab79365b4cabb1bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>9,10-Dimethyl-1,2-benzanthracene - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>corpus luteum</topic><topic>Corpus Luteum - pathology</topic><topic>dimethylbenz(a)anthracene</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>morphometrics</topic><topic>mouse</topic><topic>Organ Size - drug effects</topic><topic>Ovarian Diseases - chemically induced</topic><topic>Ovarian Diseases - pathology</topic><topic>ovary</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>polycyclic aromatic hydrocarbon</topic><topic>reproductive toxicant</topic><topic>smoking</topic><topic>Tobacco, tobacco smoking</topic><topic>toxicant</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weitzman, Glenn A.</creatorcontrib><creatorcontrib>Miller, Michael M.</creatorcontrib><creatorcontrib>London, Steve N.</creatorcontrib><creatorcontrib>Mattison, Donald R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weitzman, Glenn A.</au><au>Miller, Michael M.</au><au>London, Steve N.</au><au>Mattison, Donald R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>1992</date><risdate>1992</risdate><volume>6</volume><issue>2</issue><spage>137</spage><epage>141</epage><pages>137-141</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>7,12-Dimethylbenz(a)anthracene (DMBA) is a polycyclic aromatic hydrocarbon and a component of cigarette smoke that has been identified as a murine reproductive toxicant. The morphometric parameters of total ovarian volume, individual corpus luteum volumes, and total corpora lutea volume were measured in C57BL/6N mice treated with DMBA. Each group received single intraperitoneal injections of 0, 0.1, 1.0, or 10 mg/kg and were sacrificed at 1, 2, 3, or 4 weeks after treatment. DMBA produced a dose-dependent decrease in ovarian volume and number of corpora lutea in each ovary. The observed reduction in total corpora lutea volume did not fully account for the loss in total ovarian volume. This is consistent with previous descriptions of a toxic effect on all ovarian components including growing and resting follicles. Growing follicles that escaped the toxic effects of DMBA and achieved ovulation resulted in a corpus luteum that appeared histologically normal. Morphometric analysis of this animal model further defines the dynamic changes in the mouse ovary in response to DMBA.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1591471</pmid><doi>10.1016/0890-6238(92)90115-A</doi><tpages>5</tpages></addata></record> |
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| ispartof | Reproductive toxicology (Elmsford, N.Y.), 1992, Vol.6 (2), p.137-141 |
| issn | 0890-6238 1873-1708 |
| language | eng |
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| subjects | 9,10-Dimethyl-1,2-benzanthracene - toxicity Animals Biological and medical sciences corpus luteum Corpus Luteum - pathology dimethylbenz(a)anthracene Female Medical sciences Mice Mice, Inbred C57BL morphometrics mouse Organ Size - drug effects Ovarian Diseases - chemically induced Ovarian Diseases - pathology ovary Ovary - drug effects Ovary - pathology polycyclic aromatic hydrocarbon reproductive toxicant smoking Tobacco, tobacco smoking toxicant Toxicology |
| title | Morphometric assessment of the murine ovarian toxicity of 7,12-dimethylbenz(a)anthracene |
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