Parasitic scabies mites and associated bacteria joining forces against host complement defence
Summary Scabies is a ubiquitous and contagious skin disease caused by the parasitic mite Sarcoptes scabiei Epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. This is an important notion, as su...
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| Veröffentlicht in: | Parasite immunology 2014-11, Vol.36 (11), p.585-593 |
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| container_title | Parasite immunology |
| container_volume | 36 |
| creator | Swe, P. M. Reynolds, S. L. Fischer, K. |
| description | Summary
Scabies is a ubiquitous and contagious skin disease caused by the parasitic mite Sarcoptes scabiei Epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. This is an important notion, as such bacterial infections can lead to serious downstream life‐threatening complications. As the complement system is the first line of host defence that confronts invading pathogens, both the mite and bacteria produce a large array of molecules that inhibit the complement cascades. It is hypothesised that scabies mite complement inhibitors may play an important role in providing a favourable micro‐environment for the establishment of secondary bacterial infections. This review aims to bring together the current literature on complement inhibition by scabies mites and bacteria associated with scabies and to discuss the proposed molecular link between scabies and bacterial co‐infections. |
| doi_str_mv | 10.1111/pim.12133 |
| format | Article |
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Scabies is a ubiquitous and contagious skin disease caused by the parasitic mite Sarcoptes scabiei Epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. This is an important notion, as such bacterial infections can lead to serious downstream life‐threatening complications. As the complement system is the first line of host defence that confronts invading pathogens, both the mite and bacteria produce a large array of molecules that inhibit the complement cascades. It is hypothesised that scabies mite complement inhibitors may play an important role in providing a favourable micro‐environment for the establishment of secondary bacterial infections. This review aims to bring together the current literature on complement inhibition by scabies mites and bacteria associated with scabies and to discuss the proposed molecular link between scabies and bacterial co‐infections.</description><identifier>ISSN: 0141-9838</identifier><identifier>EISSN: 1365-3024</identifier><identifier>DOI: 10.1111/pim.12133</identifier><identifier>PMID: 25081184</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Coinfection - immunology ; Coinfection - parasitology ; Coinfection - veterinary ; coinfection – disease ; Complement System Proteins ; complement – immunological terms ; human – host species ; Humans ; Immune Evasion ; Sarcoptes scabiei - physiology ; sarcoptes – parasite ; Scabies - immunology ; Scabies - parasitology ; Scabies - veterinary ; Skin Diseases, Infectious - immunology ; Skin Diseases, Infectious - parasitology ; Skin Diseases, Infectious - veterinary ; Staphylococcus aureus - physiology ; Staphylococcus aureus – bacteria ; Streptococcus pyogenes - physiology ; Streptococcus pyogenes – bacteria</subject><ispartof>Parasite immunology, 2014-11, Vol.36 (11), p.585-593</ispartof><rights>2014 John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3253-dba9dbd2ab6a5cee22a23da4c4610b5a4d4b33762f2992ab97167d074f059db23</citedby><cites>FETCH-LOGICAL-c3253-dba9dbd2ab6a5cee22a23da4c4610b5a4d4b33762f2992ab97167d074f059db23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpim.12133$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpim.12133$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25081184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Swe, P. M.</creatorcontrib><creatorcontrib>Reynolds, S. L.</creatorcontrib><creatorcontrib>Fischer, K.</creatorcontrib><title>Parasitic scabies mites and associated bacteria joining forces against host complement defence</title><title>Parasite immunology</title><addtitle>Parasite Immunol</addtitle><description>Summary
Scabies is a ubiquitous and contagious skin disease caused by the parasitic mite Sarcoptes scabiei Epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. This is an important notion, as such bacterial infections can lead to serious downstream life‐threatening complications. As the complement system is the first line of host defence that confronts invading pathogens, both the mite and bacteria produce a large array of molecules that inhibit the complement cascades. It is hypothesised that scabies mite complement inhibitors may play an important role in providing a favourable micro‐environment for the establishment of secondary bacterial infections. This review aims to bring together the current literature on complement inhibition by scabies mites and bacteria associated with scabies and to discuss the proposed molecular link between scabies and bacterial co‐infections.</description><subject>Animals</subject><subject>Coinfection - immunology</subject><subject>Coinfection - parasitology</subject><subject>Coinfection - veterinary</subject><subject>coinfection – disease</subject><subject>Complement System Proteins</subject><subject>complement – immunological terms</subject><subject>human – host species</subject><subject>Humans</subject><subject>Immune Evasion</subject><subject>Sarcoptes scabiei - physiology</subject><subject>sarcoptes – parasite</subject><subject>Scabies - immunology</subject><subject>Scabies - parasitology</subject><subject>Scabies - veterinary</subject><subject>Skin Diseases, Infectious - immunology</subject><subject>Skin Diseases, Infectious - parasitology</subject><subject>Skin Diseases, Infectious - veterinary</subject><subject>Staphylococcus aureus - physiology</subject><subject>Staphylococcus aureus – bacteria</subject><subject>Streptococcus pyogenes - physiology</subject><subject>Streptococcus pyogenes – bacteria</subject><issn>0141-9838</issn><issn>1365-3024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOw0AQRVcIREKg4AeQSyic7Mtru0QRj0ggUkCLNbs7Dhv5EbyOUP6eDQ50THGnOXOlOYRcMjplYWYbV08ZZ0IckTETKokF5fKYjCmTLM4zkY3ImfdrSpngSpySEU9oxlgmx-R9CR141zsTeQPaoY9q14eExkbgfWsc9GgjDabHzkG0bl3jmlVUtp3ZYytwje-jjzaEaetNhTU2fWSxxMbgOTkpofJ4cdgT8nZ_9zp_jJ9eHhbz26fYCJ6I2GrIrbYctILEIHIOXFiQRipGdQLSSi1EqnjJ8zxQecpUamkqS5qEQy4m5Hro3XTt5xZ9X9TOG6wqaLDd-oIplovwsJIBvRlQ07Xed1gWm87V0O0KRou9ziLoLH50BvbqULvVNdo_8tdfAGYD8OUq3P3fVCwXz0PlN2Kef-k</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Swe, P. M.</creator><creator>Reynolds, S. L.</creator><creator>Fischer, K.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201411</creationdate><title>Parasitic scabies mites and associated bacteria joining forces against host complement defence</title><author>Swe, P. M. ; Reynolds, S. L. ; Fischer, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3253-dba9dbd2ab6a5cee22a23da4c4610b5a4d4b33762f2992ab97167d074f059db23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Coinfection - immunology</topic><topic>Coinfection - parasitology</topic><topic>Coinfection - veterinary</topic><topic>coinfection – disease</topic><topic>Complement System Proteins</topic><topic>complement – immunological terms</topic><topic>human – host species</topic><topic>Humans</topic><topic>Immune Evasion</topic><topic>Sarcoptes scabiei - physiology</topic><topic>sarcoptes – parasite</topic><topic>Scabies - immunology</topic><topic>Scabies - parasitology</topic><topic>Scabies - veterinary</topic><topic>Skin Diseases, Infectious - immunology</topic><topic>Skin Diseases, Infectious - parasitology</topic><topic>Skin Diseases, Infectious - veterinary</topic><topic>Staphylococcus aureus - physiology</topic><topic>Staphylococcus aureus – bacteria</topic><topic>Streptococcus pyogenes - physiology</topic><topic>Streptococcus pyogenes – bacteria</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Swe, P. M.</creatorcontrib><creatorcontrib>Reynolds, S. L.</creatorcontrib><creatorcontrib>Fischer, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Parasite immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Swe, P. M.</au><au>Reynolds, S. L.</au><au>Fischer, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Parasitic scabies mites and associated bacteria joining forces against host complement defence</atitle><jtitle>Parasite immunology</jtitle><addtitle>Parasite Immunol</addtitle><date>2014-11</date><risdate>2014</risdate><volume>36</volume><issue>11</issue><spage>585</spage><epage>593</epage><pages>585-593</pages><issn>0141-9838</issn><eissn>1365-3024</eissn><abstract>Summary
Scabies is a ubiquitous and contagious skin disease caused by the parasitic mite Sarcoptes scabiei Epidemiological studies have identified scabies as a causative agent for secondary skin infections caused by Staphylococcus aureus and Streptococcus pyogenes. This is an important notion, as such bacterial infections can lead to serious downstream life‐threatening complications. As the complement system is the first line of host defence that confronts invading pathogens, both the mite and bacteria produce a large array of molecules that inhibit the complement cascades. It is hypothesised that scabies mite complement inhibitors may play an important role in providing a favourable micro‐environment for the establishment of secondary bacterial infections. This review aims to bring together the current literature on complement inhibition by scabies mites and bacteria associated with scabies and to discuss the proposed molecular link between scabies and bacterial co‐infections.</abstract><cop>England</cop><pmid>25081184</pmid><doi>10.1111/pim.12133</doi><tpages>9</tpages></addata></record> |
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| issn | 0141-9838 1365-3024 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Coinfection - immunology Coinfection - parasitology Coinfection - veterinary coinfection – disease Complement System Proteins complement – immunological terms human – host species Humans Immune Evasion Sarcoptes scabiei - physiology sarcoptes – parasite Scabies - immunology Scabies - parasitology Scabies - veterinary Skin Diseases, Infectious - immunology Skin Diseases, Infectious - parasitology Skin Diseases, Infectious - veterinary Staphylococcus aureus - physiology Staphylococcus aureus – bacteria Streptococcus pyogenes - physiology Streptococcus pyogenes – bacteria |
| title | Parasitic scabies mites and associated bacteria joining forces against host complement defence |
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