Role of Platelet Inhibition in Microvascular Surgery
Abstract Thrombosis remains a significant complication of microvascular free tissue transfer. Recent discoveries in the field of vascular biology have led to a greater understanding of thrombogenesis and the pivotal role that platelets play in the formation of a clot. However, current antithrombotic...
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| Veröffentlicht in: | Journal of reconstructive microsurgery 2014-11, Vol.30 (9), p.589-598 |
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| container_title | Journal of reconstructive microsurgery |
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| creator | Cho, Eugenia H. Ligh, Cassandra Hodulik, Kimberly L. Hollenbeck, Scott T. |
| description | Abstract
Thrombosis remains a significant complication of microvascular free tissue transfer. Recent discoveries in the field of vascular biology have led to a greater understanding of thrombogenesis and the pivotal role that platelets play in the formation of a clot. However, current antithrombotic strategies in the clinical practice of free tissue transfer have not typically focused on platelet inhibition. Decades of cardiovascular clinical trials have delineated the essential role of platelet inhibitor therapy in patients with acute coronary syndromes and those undergoing percutaneous coronary interventions. Understanding the current treatment guidelines for antiplatelet therapy across the spectrum of patients with coronary heart disease may provide insights into their use in the prevention and treatment of thrombosis in microvascular surgery. In this review, we examine the current antiplatelet agents in clinical use and discuss the potential role of platelet inhibition in free flap surgery, particularly in the setting of repeated microvascular thrombosis. |
| doi_str_mv | 10.1055/s-0034-1381955 |
| format | Article |
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Thrombosis remains a significant complication of microvascular free tissue transfer. Recent discoveries in the field of vascular biology have led to a greater understanding of thrombogenesis and the pivotal role that platelets play in the formation of a clot. However, current antithrombotic strategies in the clinical practice of free tissue transfer have not typically focused on platelet inhibition. Decades of cardiovascular clinical trials have delineated the essential role of platelet inhibitor therapy in patients with acute coronary syndromes and those undergoing percutaneous coronary interventions. Understanding the current treatment guidelines for antiplatelet therapy across the spectrum of patients with coronary heart disease may provide insights into their use in the prevention and treatment of thrombosis in microvascular surgery. In this review, we examine the current antiplatelet agents in clinical use and discuss the potential role of platelet inhibition in free flap surgery, particularly in the setting of repeated microvascular thrombosis.</description><identifier>ISSN: 0743-684X</identifier><identifier>EISSN: 1098-8947</identifier><identifier>DOI: 10.1055/s-0034-1381955</identifier><identifier>PMID: 25089565</identifier><language>eng</language><publisher>333 Seventh Avenue, New York, NY 10001, USA: Thieme Medical Publishers</publisher><subject>Angina, Unstable - drug therapy ; Aspirin - pharmacology ; Coronary Disease - drug therapy ; Endothelium, Vascular - physiopathology ; Free Tissue Flaps ; Humans ; Invited Review ; Platelet Adhesiveness - physiology ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - pharmacology ; Platelet Aggregation Inhibitors - therapeutic use ; Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors ; Venous Thrombosis - prevention & control</subject><ispartof>Journal of reconstructive microsurgery, 2014-11, Vol.30 (9), p.589-598</ispartof><rights>Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-34cdb9fa08789a0cb7bcc592e0899bbcd79fd877dd1916dbd0b781368a59ed943</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0034-1381955.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-0034-1381955$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,776,780,3003,3004,27903,27904,54538,54539</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25089565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Eugenia H.</creatorcontrib><creatorcontrib>Ligh, Cassandra</creatorcontrib><creatorcontrib>Hodulik, Kimberly L.</creatorcontrib><creatorcontrib>Hollenbeck, Scott T.</creatorcontrib><title>Role of Platelet Inhibition in Microvascular Surgery</title><title>Journal of reconstructive microsurgery</title><addtitle>J reconstr Microsurg</addtitle><description>Abstract
Thrombosis remains a significant complication of microvascular free tissue transfer. Recent discoveries in the field of vascular biology have led to a greater understanding of thrombogenesis and the pivotal role that platelets play in the formation of a clot. However, current antithrombotic strategies in the clinical practice of free tissue transfer have not typically focused on platelet inhibition. Decades of cardiovascular clinical trials have delineated the essential role of platelet inhibitor therapy in patients with acute coronary syndromes and those undergoing percutaneous coronary interventions. Understanding the current treatment guidelines for antiplatelet therapy across the spectrum of patients with coronary heart disease may provide insights into their use in the prevention and treatment of thrombosis in microvascular surgery. In this review, we examine the current antiplatelet agents in clinical use and discuss the potential role of platelet inhibition in free flap surgery, particularly in the setting of repeated microvascular thrombosis.</description><subject>Angina, Unstable - drug therapy</subject><subject>Aspirin - pharmacology</subject><subject>Coronary Disease - drug therapy</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Free Tissue Flaps</subject><subject>Humans</subject><subject>Invited Review</subject><subject>Platelet Adhesiveness - physiology</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - pharmacology</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors</subject><subject>Venous Thrombosis - prevention & control</subject><issn>0743-684X</issn><issn>1098-8947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EoqWwMqKMLC52bcf2iCoelUAgHhKb5VeoKycpdoLUf0-qFjamu5z7ffceAM4xmmLE2FWGCBEKMRFYMnYAxhhJAYWk_BCMEacEloJ-jMBJziuEMJV4dgxGM4aEZCUbA_rSRl-0VfEcdeej74pFswwmdKFtitAUj8Gm9ltn20editc-ffq0OQVHlY7Zn-3nBLzf3rzN7-HD091ifv0ALeWkg4RaZ2SlkeBCamQNN9YyOfNDuTTGOi4rJzh3DktcOuOQ4QKTUmgmvZOUTMDlLned2q_e507VIVsfo25822eFSywJFpiRAZ3u0OHcnJOv1DqFWqeNwkhtTamstqbU3tSwcLHP7k3t3R_-q2YA4A7olsHXXq3aPjXDt_8F_gA0G3FI</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Cho, Eugenia H.</creator><creator>Ligh, Cassandra</creator><creator>Hodulik, Kimberly L.</creator><creator>Hollenbeck, Scott T.</creator><general>Thieme Medical Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Role of Platelet Inhibition in Microvascular Surgery</title><author>Cho, Eugenia H. ; Ligh, Cassandra ; Hodulik, Kimberly L. ; Hollenbeck, Scott T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-34cdb9fa08789a0cb7bcc592e0899bbcd79fd877dd1916dbd0b781368a59ed943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angina, Unstable - drug therapy</topic><topic>Aspirin - pharmacology</topic><topic>Coronary Disease - drug therapy</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Free Tissue Flaps</topic><topic>Humans</topic><topic>Invited Review</topic><topic>Platelet Adhesiveness - physiology</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - pharmacology</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors</topic><topic>Venous Thrombosis - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Eugenia H.</creatorcontrib><creatorcontrib>Ligh, Cassandra</creatorcontrib><creatorcontrib>Hodulik, Kimberly L.</creatorcontrib><creatorcontrib>Hollenbeck, Scott T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reconstructive microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Eugenia H.</au><au>Ligh, Cassandra</au><au>Hodulik, Kimberly L.</au><au>Hollenbeck, Scott T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Platelet Inhibition in Microvascular Surgery</atitle><jtitle>Journal of reconstructive microsurgery</jtitle><addtitle>J reconstr Microsurg</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>30</volume><issue>9</issue><spage>589</spage><epage>598</epage><pages>589-598</pages><issn>0743-684X</issn><eissn>1098-8947</eissn><abstract>Abstract
Thrombosis remains a significant complication of microvascular free tissue transfer. Recent discoveries in the field of vascular biology have led to a greater understanding of thrombogenesis and the pivotal role that platelets play in the formation of a clot. However, current antithrombotic strategies in the clinical practice of free tissue transfer have not typically focused on platelet inhibition. Decades of cardiovascular clinical trials have delineated the essential role of platelet inhibitor therapy in patients with acute coronary syndromes and those undergoing percutaneous coronary interventions. Understanding the current treatment guidelines for antiplatelet therapy across the spectrum of patients with coronary heart disease may provide insights into their use in the prevention and treatment of thrombosis in microvascular surgery. In this review, we examine the current antiplatelet agents in clinical use and discuss the potential role of platelet inhibition in free flap surgery, particularly in the setting of repeated microvascular thrombosis.</abstract><cop>333 Seventh Avenue, New York, NY 10001, USA</cop><pub>Thieme Medical Publishers</pub><pmid>25089565</pmid><doi>10.1055/s-0034-1381955</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Angina, Unstable - drug therapy Aspirin - pharmacology Coronary Disease - drug therapy Endothelium, Vascular - physiopathology Free Tissue Flaps Humans Invited Review Platelet Adhesiveness - physiology Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Venous Thrombosis - prevention & control |
| title | Role of Platelet Inhibition in Microvascular Surgery |
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