Risk Factors for Critical Disease and Death from Hand, Foot and Mouth Disease
There has been a high mortality and morbidity rate of critical and fatal patients from hand, foot and mouth disease (HFMD) in China in recent. Causes for development of critical and fatal disease remain unclear. We performed a case-control study to assess the association between use of drugs and dev...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2014-09, Vol.33 (9), p.966-970 |
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| container_end_page | 970 |
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| container_issue | 9 |
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| container_title | The Pediatric infectious disease journal |
| container_volume | 33 |
| creator | YILIN HE JIANGUO YANG GUANG ZENG TAO SHEN FONTAINE, Robert E LIJIE ZHANG GUOQING SHI YULIN WANG QIN LI JIANG LONG |
| description | There has been a high mortality and morbidity rate of critical and fatal patients from hand, foot and mouth disease (HFMD) in China in recent. Causes for development of critical and fatal disease remain unclear.
We performed a case-control study to assess the association between use of drugs and development of critical disease and death from HFMD.
We found that glucocorticoids treatment was associated with a greater incidence of severe HFMD, whereas andrographolides treatment was associated with a protective effect when they are used for treatment within 48 hours after onset or before being diagnosed as critical.
We recommend that glucocorticoids should not be used for mild HFMD and andrographolides should undergo clinical trials for treatment of enterovirus 71 infections. |
| doi_str_mv | 10.1097/INF.0000000000000319 |
| format | Article |
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We performed a case-control study to assess the association between use of drugs and development of critical disease and death from HFMD.
We found that glucocorticoids treatment was associated with a greater incidence of severe HFMD, whereas andrographolides treatment was associated with a protective effect when they are used for treatment within 48 hours after onset or before being diagnosed as critical.
We recommend that glucocorticoids should not be used for mild HFMD and andrographolides should undergo clinical trials for treatment of enterovirus 71 infections.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/INF.0000000000000319</identifier><identifier>PMID: 24577041</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animal viral diseases ; Antiviral Agents - therapeutic use ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; China - epidemiology ; Critical Illness ; Diterpenes - therapeutic use ; Female ; Glucocorticoids - administration & dosage ; Glucocorticoids - adverse effects ; Hand, Foot and Mouth Disease - drug therapy ; Hand, Foot and Mouth Disease - mortality ; Humans ; Infant ; Infectious diseases ; Male ; Medical sciences ; Risk Factors ; Severity of Illness Index ; Time Factors ; Viral diseases</subject><ispartof>The Pediatric infectious disease journal, 2014-09, Vol.33 (9), p.966-970</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-42ab6fa72c9486a0012a6ebe6c01b40eae28bfeedbeb974cae10338bdbed40383</citedby><cites>FETCH-LOGICAL-c407t-42ab6fa72c9486a0012a6ebe6c01b40eae28bfeedbeb974cae10338bdbed40383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28807853$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24577041$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YILIN HE</creatorcontrib><creatorcontrib>JIANGUO YANG</creatorcontrib><creatorcontrib>GUANG ZENG</creatorcontrib><creatorcontrib>TAO SHEN</creatorcontrib><creatorcontrib>FONTAINE, Robert E</creatorcontrib><creatorcontrib>LIJIE ZHANG</creatorcontrib><creatorcontrib>GUOQING SHI</creatorcontrib><creatorcontrib>YULIN WANG</creatorcontrib><creatorcontrib>QIN LI</creatorcontrib><creatorcontrib>JIANG LONG</creatorcontrib><title>Risk Factors for Critical Disease and Death from Hand, Foot and Mouth Disease</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>There has been a high mortality and morbidity rate of critical and fatal patients from hand, foot and mouth disease (HFMD) in China in recent. Causes for development of critical and fatal disease remain unclear.
We performed a case-control study to assess the association between use of drugs and development of critical disease and death from HFMD.
We found that glucocorticoids treatment was associated with a greater incidence of severe HFMD, whereas andrographolides treatment was associated with a protective effect when they are used for treatment within 48 hours after onset or before being diagnosed as critical.
We recommend that glucocorticoids should not be used for mild HFMD and andrographolides should undergo clinical trials for treatment of enterovirus 71 infections.</description><subject>Animal viral diseases</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China - epidemiology</subject><subject>Critical Illness</subject><subject>Diterpenes - therapeutic use</subject><subject>Female</subject><subject>Glucocorticoids - administration & dosage</subject><subject>Glucocorticoids - adverse effects</subject><subject>Hand, Foot and Mouth Disease - drug therapy</subject><subject>Hand, Foot and Mouth Disease - mortality</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Viral diseases</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkN9LwzAQx4Mobk7_A5G8CD7YmTRpkz7KZp2wKYg-lyS9YrVdZtI--N-bufoD7-U4vp-7gw9Cp5RMKcnE1d19PiV_i9FsD41pwuKIZFLsozGRGY1YmsoROvL-dctwSg7RKOaJEITTMVo91v4N58p01nlcWYdnru5qoxo8rz0oD1itSzwH1b3gytkWL8J8iXNru69kZfuQDOwxOqhU4-Fk6BP0nN88zRbR8uH2bna9jAwnoot4rHRaKRGbjMtUEUJjlYKG1BCqOQEFsdQVQKlBZ4IbBZQwJnWYS06YZBN0sbu7cfa9B98Vbe0NNI1ag-19QVOaMZqyJAko36HGWe8dVMXG1a1yHwUlxVZkEUQW_0WGtbPhQ69bKH-Wvs0F4HwAlA-2KqfWpva_nJREyISxT60fefY</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>YILIN HE</creator><creator>JIANGUO YANG</creator><creator>GUANG ZENG</creator><creator>TAO SHEN</creator><creator>FONTAINE, Robert E</creator><creator>LIJIE ZHANG</creator><creator>GUOQING SHI</creator><creator>YULIN WANG</creator><creator>QIN LI</creator><creator>JIANG LONG</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20140901</creationdate><title>Risk Factors for Critical Disease and Death from Hand, Foot and Mouth Disease</title><author>YILIN HE ; JIANGUO YANG ; GUANG ZENG ; TAO SHEN ; FONTAINE, Robert E ; LIJIE ZHANG ; GUOQING SHI ; YULIN WANG ; QIN LI ; JIANG LONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-42ab6fa72c9486a0012a6ebe6c01b40eae28bfeedbeb974cae10338bdbed40383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animal viral diseases</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China - epidemiology</topic><topic>Critical Illness</topic><topic>Diterpenes - therapeutic use</topic><topic>Female</topic><topic>Glucocorticoids - administration & dosage</topic><topic>Glucocorticoids - adverse effects</topic><topic>Hand, Foot and Mouth Disease - drug therapy</topic><topic>Hand, Foot and Mouth Disease - mortality</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YILIN HE</creatorcontrib><creatorcontrib>JIANGUO YANG</creatorcontrib><creatorcontrib>GUANG ZENG</creatorcontrib><creatorcontrib>TAO SHEN</creatorcontrib><creatorcontrib>FONTAINE, Robert E</creatorcontrib><creatorcontrib>LIJIE ZHANG</creatorcontrib><creatorcontrib>GUOQING SHI</creatorcontrib><creatorcontrib>YULIN WANG</creatorcontrib><creatorcontrib>QIN LI</creatorcontrib><creatorcontrib>JIANG LONG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YILIN HE</au><au>JIANGUO YANG</au><au>GUANG ZENG</au><au>TAO SHEN</au><au>FONTAINE, Robert E</au><au>LIJIE ZHANG</au><au>GUOQING SHI</au><au>YULIN WANG</au><au>QIN LI</au><au>JIANG LONG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Critical Disease and Death from Hand, Foot and Mouth Disease</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>33</volume><issue>9</issue><spage>966</spage><epage>970</epage><pages>966-970</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>There has been a high mortality and morbidity rate of critical and fatal patients from hand, foot and mouth disease (HFMD) in China in recent. Causes for development of critical and fatal disease remain unclear.
We performed a case-control study to assess the association between use of drugs and development of critical disease and death from HFMD.
We found that glucocorticoids treatment was associated with a greater incidence of severe HFMD, whereas andrographolides treatment was associated with a protective effect when they are used for treatment within 48 hours after onset or before being diagnosed as critical.
We recommend that glucocorticoids should not be used for mild HFMD and andrographolides should undergo clinical trials for treatment of enterovirus 71 infections.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>24577041</pmid><doi>10.1097/INF.0000000000000319</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0891-3668 |
| ispartof | The Pediatric infectious disease journal, 2014-09, Vol.33 (9), p.966-970 |
| issn | 0891-3668 1532-0987 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animal viral diseases Antiviral Agents - therapeutic use Biological and medical sciences Case-Control Studies Child Child, Preschool China - epidemiology Critical Illness Diterpenes - therapeutic use Female Glucocorticoids - administration & dosage Glucocorticoids - adverse effects Hand, Foot and Mouth Disease - drug therapy Hand, Foot and Mouth Disease - mortality Humans Infant Infectious diseases Male Medical sciences Risk Factors Severity of Illness Index Time Factors Viral diseases |
| title | Risk Factors for Critical Disease and Death from Hand, Foot and Mouth Disease |
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