Colistin resistance superimposed to endemic carbapenem-resistant Klebsiella pneumoniae: a rapidly evolving problem in Italy, November 2013 to April 2014

Consecutive non-replicate clinical isolates (n=191) of carbapenem non-susceptible Enterobacteriaceae were collected from 21 hospital laboratories across Italy from November 2013 to April 2014 as part of the European Survey on Carbapenemase-producing Enterobacteriaceae (EuSCAPE) project. Klebsiella p...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2014-10, Vol.19 (42), p.1
Hauptverfasser:	Monaco, M, Giani, T, Raffone, M, Arena, F, Garcia-Fernandez, A, Pollini, S, Grundmann, H, Pantosti, A, Rossolini, G M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenems - pharmacology Colistin - pharmacology Colistin - therapeutic use Drug resistance Drug Resistance, Multiple, Bacterial Endemic Diseases Health Surveys Humans Italy - epidemiology Klebsiella Infections - drug therapy Klebsiella Infections - epidemiology Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Laboratories, Hospital Medical treatment Microbial Sensitivity Tests Polymerase Chain Reaction Sentinel Surveillance
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Zusammenfassung:	Consecutive non-replicate clinical isolates (n=191) of carbapenem non-susceptible Enterobacteriaceae were collected from 21 hospital laboratories across Italy from November 2013 to April 2014 as part of the European Survey on Carbapenemase-producing Enterobacteriaceae (EuSCAPE) project. Klebsiella pneumonia carbapenemase-producing K. pneumoniae (KPC-KP) represented 178 (93%) isolates with 76 (43%) respectively resistant to colistin, a key drug for treating carbapenamase-producing Enterobacteriaceae. KPC-KP colistin-resistant isolates were detected in all participating laboratories. This underscores a concerning evolution of colistin resistance in a setting of high KPC-KP endemicity.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.es2014.19.42.20939